Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPACEI1168(ACE-inhibitory peptide)

DFBP ID	DFBPACEI1168
Peptide sequence	AAPL
Type	Native peptide
Peptide/Function name	ACE-inhibitory peptide

Function-activity relationship

Main bioactivity	ACE-inhibitory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Ala-Ala-Pro-Leu

Single-letter amino acid

AAPL

Peptide length

Peptide mass

Experimental mass	Theoretical mass
370.22 Da	370.43 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.97 ^c

IC₅₀

> 1000 uM

pIC₅₀

> -3.0

GRAVY

1.4500^c

Hydrophilic residue ratio

100%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Dry-cured ham
Precursor protein	Dry-cured ham extracts
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0864 ---- Plant proteins ---- Growth-regulating factor 4 Source.2: DFBPPR1061 ---- Plant proteins ---- Cinnamyl alcohol dehydrogenase 2 Source.3: DFBPPR1130 ---- Plant proteins ---- Hexokinase-4, chloroplastic Source.4: DFBPPR1260 ---- Plant proteins ---- Peptide deformylase 1A, chloroplastic Source.5: DFBPPR1314 ---- Plant proteins ---- Ferredoxin-dependent glutamate synthase, chloroplastic Source.6: DFBPPR1378 ---- Plant proteins ---- bZIP transcription factor TRAB1 Source.7: DFBPPR1387 ---- Plant proteins ---- Calcium-transporting ATPase 7, plasma membrane-type Source.8: DFBPPR1453 ---- Plant proteins ---- Crossover junction endonuclease MUS81 Source.9: DFBPPR1474 ---- Plant proteins ---- Beta-fructofuranosidase, insoluble isoenzyme 7 Source.10: DFBPPR1505 ---- Plant proteins ---- Bidirectional sugar transporter SWEET5 Source.11: DFBPPR1547 ---- Plant proteins ---- AP2-like ethylene-responsive transcription factor CRL5 Source.12: DFBPPR1633 ---- Plant proteins ---- Coronatine-insensitive protein homolog 1a Source.13: DFBPPR1644 ---- Plant proteins ---- Phosphoenolpyruvate/phosphate translocator 1, chloroplastic Source.14: DFBPPR1697 ---- Plant proteins ---- Probable RNA-dependent RNA polymerase SHL2 Source.15: DFBPPR1714 ---- Plant proteins ---- Protein MAO HUZI 4, chloroplastic Source.16: DFBPPR1740 ---- Plant proteins ---- Protein ETHYLENE-INSENSITIVE 2 Source.17: DFBPPR1746 ---- Plant proteins ---- Protein LAX PANICLE 2 Source.18: DFBPPR1828 ---- Plant proteins ---- Sphingosine-1-phosphate lyase Source.19: DFBPPR1846 ---- Plant proteins ---- Cytokinin dehydrogenase 1 Source.20: DFBPPR1847 ---- Plant proteins ---- Amidase 1 Source.21: DFBPPR1877 ---- Plant proteins ---- Cyclin-dependent kinase F-4 Source.22: DFBPPR1899 ---- Plant proteins ---- High-affinity nitrate transporter 2.1 Source.23: DFBPPR1909 ---- Plant proteins ---- High-affinity nitrate transporter 2.2 Source.24: DFBPPR1961 ---- Plant proteins ---- Homeobox-leucine zipper protein HOX2 Source.25: DFBPPR1980 ---- Plant proteins ---- Germin-like protein 1-4 Source.26: DFBPPR2049 ---- Plant proteins ---- Auxin response factor 19 Source.27: DFBPPR2077 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 8C Source.28: DFBPPR2122 ---- Plant proteins ---- FAD-linked sulfhydryl oxidase ERV1 Source.29: DFBPPR2233 ---- Plant proteins ---- Thioredoxin Y, chloroplastic Source.30: DFBPPR2306 ---- Plant proteins ---- Germin-like protein 3-7 Source.31: DFBPPR2337 ---- Plant proteins ---- Protein TIFY 11b Source.32: DFBPPR2355 ---- Plant proteins ---- Probable glycosyltransferase 5 Source.33: DFBPPR2365 ---- Plant proteins ---- Auxin response factor 5 Source.34: DFBPPR2434 ---- Plant proteins ---- Non-specific lipid transfer protein-like 1 Source.35: DFBPPR2475 ---- Plant proteins ---- Alcohol dehydrogenase 1 Source.36: DFBPPR2488 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 1 Source.37: DFBPPR2531 ---- Plant proteins ---- Putative cinnamyl alcohol dehydrogenase 4 Source.38: DFBPPR2537 ---- Plant proteins ---- Uridine 5'-monophosphate synthase Source.39: DFBPPR2585 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 8B Source.40: DFBPPR2594 ---- Plant proteins ---- Protein HAPLESS 2-A Source.41: DFBPPR2643 ---- Plant proteins ---- Coronatine-insensitive protein homolog 1b Source.42: DFBPPR2668 ---- Plant proteins ---- Two-component response regulator ORR33 Source.43: DFBPPR2749 ---- Plant proteins ---- Bidirectional sugar transporter SWEET15 Source.44: DFBPPR2792 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 8A Source.45: DFBPPR2798 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 6 Source.46: DFBPPR2804 ---- Plant proteins ---- Protein GIGANTEA Source.47: DFBPPR2812 ---- Plant proteins ---- Lysine-specific histone demethylase 1 homolog 1 Source.48: DFBPPR2814 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase 8D Source.49: DFBPPR2868 ---- Plant proteins ---- Probable 4-coumarate--CoA ligase 2 Source.50: DFBPPR2870 ---- Plant proteins ---- Homeobox-leucine zipper protein HOX27 Source.51: DFBPPR2924 ---- Plant proteins ---- Probable glycosyltransferase 7 Source.52: DFBPPR2932 ---- Plant proteins ---- Auxin response factor 14 Source.53: DFBPPR2953 ---- Plant proteins ---- Germin-like protein 5-1 Source.54: DFBPPR3023 ---- Plant proteins ---- RNA pseudouridine synthase 6, chloroplastic Source.55: DFBPPR3026 ---- Plant proteins ---- Polyprenol reductase 1 Source.56: DFBPPR3040 ---- Plant proteins ---- Translation factor GUF1 homolog, chloroplastic Source.57: DFBPPR3062 ---- Plant proteins ---- Polyprenol reductase 2 Source.58: DFBPPR3110 ---- Plant proteins ---- Thioredoxin H5 Source.59: DFBPPR3239 ---- Plant proteins ---- Pyruvate dehydrogenase E1 component subunit beta-4, chloroplastic Source.60: DFBPPR3255 ---- Plant proteins ---- COBRA-like protein 6 Source.61: DFBPPR3269 ---- Plant proteins ---- Auxin response factor 13 Source.62: DFBPPR3272 ---- Plant proteins ---- NPL4-like protein Source.63: DFBPPR3283 ---- Plant proteins ---- Auxin-responsive protein IAA21 Source.64: DFBPPR3286 ---- Plant proteins ---- Expansin-A32 Source.65: DFBPPR3340 ---- Plant proteins ---- Beta-galactosidase 5 Source.66: DFBPPR3344 ---- Plant proteins ---- Bidirectional sugar transporter SWEET4 Source.67: DFBPPR3373 ---- Plant proteins ---- 4-coumarate--CoA ligase-like 1 Source.68: DFBPPR3383 ---- Plant proteins ---- Chalcone synthase 2 Source.69: DFBPPR3409 ---- Plant proteins ---- DEAD-box ATP-dependent RNA helicase 9 Source.70: DFBPPR3438 ---- Plant proteins ---- Protein ROLLING AND ERECT LEAF 2 Source.71: DFBPPR3463 ---- Plant proteins ---- Protein THYLAKOID RHODANESE-LIKE, chloroplastic Source.72: DFBPPR3503 ---- Plant proteins ---- Kinesin-like protein KIN-14P Source.73: DFBPPR3545 ---- Plant proteins ---- Auxin response factor 3 Source.74: DFBPPR3568 ---- Plant proteins ---- Bidirectional sugar transporter SWEET16 Source.75: DFBPPR3573 ---- Plant proteins ---- Protein TIFY 5 Source.76: DFBPPR3593 ---- Plant proteins ---- Zinc finger A20 and AN1 domain-containing stress-associated protein 1 Source.77: DFBPPR3599 ---- Plant proteins ---- Protein PHOSPHATE-INDUCED 1 homolog Source.78: DFBPPR3628 ---- Plant proteins ---- Kinesin-like protein KIN-13B Source.79: DFBPPR3738 ---- Plant proteins ---- Potassium transporter 24 Source.80: DFBPPR3747 ---- Plant proteins ---- Cysteine proteinase inhibitor 12 Source.81: DFBPPR3751 ---- Plant proteins ---- 4-coumarate--CoA ligase-like 9 Source.82: DFBPPR3865 ---- Plant proteins ---- CDK5RAP1-like protein Source.83: DFBPPR3919 ---- Plant proteins ---- RecQ-mediated genome instability protein 1 Source.84: DFBPPR3927 ---- Plant proteins ---- Basic leucine zipper 2 Source.85: DFBPPR3937 ---- Plant proteins ---- Zinc-finger homeodomain protein 10 Source.86: DFBPPR3971 ---- Plant proteins ---- WUSCHEL-related homeobox 12 Source.87: DFBPPR3985 ---- Plant proteins ---- 4-coumarate--CoA ligase-like 2 Source.88: DFBPPR4011 ---- Plant proteins ---- Sugar transport protein MST1 Source.89: DFBPPR4135 ---- Plant proteins ---- Probable protein phosphatase 2C 31 Source.90: DFBPPR4192 ---- Plant proteins ---- Chloroplastic group IIB intron splicing facilitator CRS2, chloroplastic Source.91: DFBPPR4252 ---- Plant proteins ---- CASP-like protein 2A1 Source.92: DFBPPR4387 ---- Plant proteins ---- Dof zinc finger protein 5 Source.93: DFBPPR4395 ---- Plant proteins ---- Putative cyclin-F1-4 Source.94: DFBPPR4396 ---- Plant proteins ---- Nucleolin 2 Source.95: DFBPPR4399 ---- Plant proteins ---- IAA-amino acid hydrolase ILR1-like 5 Source.96: DFBPPR4416 ---- Plant proteins ---- Cyclin-dependent kinase inhibitor 4 Source.97: DFBPPR4657 ---- Plant proteins ---- Probable plastid-lipid-associated protein 3, chloroplastic Source.98: DFBPPR4672 ---- Plant proteins ---- Ninja-family protein Os03g0419100 Source.99: DFBPPR4678 ---- Plant proteins ---- Solute carrier family 40 member 1 Source.100: DFBPPR4821 ---- Plant proteins ---- Protein SPIRAL1-like 4 Source.101: DFBPPR4824 ---- Plant proteins ---- Putative B3 domain-containing protein Os06g0632500 Source.102: DFBPPR4847 ---- Plant proteins ---- B3 domain-containing protein Os07g0183200 Source.103: DFBPPR4918 ---- Plant proteins ---- Protein kinase PINOID Source.104: DFBPPR4946 ---- Plant proteins ---- Beta-fructofuranosidase, insoluble isoenzyme 6 Source.105: DFBPPR4969 ---- Plant proteins ---- Sulfite reductase [ferredoxin], chloroplastic Source.106: DFBPPR5228 ---- Plant proteins ---- Omega-3 fatty acid desaturase, chloroplastic Source.107: DFBPPR5302 ---- Plant proteins ---- 4-coumarate--CoA ligase 2 Source.108: DFBPPR5421 ---- Plant proteins ---- Pyruvate, phosphate dikinase regulatory protein, chloroplastic Source.109: DFBPPR5430 ---- Plant proteins ---- Leucine-rich repeat receptor-like protein FASCIATED EAR2 Source.110: DFBPPR5510 ---- Plant proteins ---- Probable cinnamyl alcohol dehydrogenase Source.111: DFBPPR5673 ---- Plant proteins ---- Aquaporin PIP1-6 Source.112: DFBPPR6043 ---- Plant proteins ---- CASP-like protein 2A1 Source.113: DFBPPR6097 ---- Plant proteins ---- CASP-like protein 2A2 Source.114: DFBPPR6145 ---- Plant proteins ---- Ninja-family protein 6 Source.115: DFBPPR6279 ---- Plant proteins ---- Sec-independent protein translocase protein TATC, chloroplastic Source.116: DFBPPR6599 ---- Plant proteins ---- Unknown protein from spot 115 of 2D-PAGE of thylakoid Source.117: DFBPPR6662 ---- Plant proteins ---- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic Source.118: DFBPPR6693 ---- Plant proteins ---- Phosphoglycerate kinase, chloroplastic Source.119: DFBPPR6875 ---- Plant proteins ---- Eukaryotic translation initiation factor 4G Source.120: DFBPPR6899 ---- Plant proteins ---- Zinc finger protein 1 Source.121: DFBPPR7466 ---- Plant proteins ---- 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic Source.122: DFBPPR7642 ---- Milk proteins ---- Inactive pancreatic lipase-related protein 1 Source.123: DFBPPR8463 ---- Plant proteins ---- RuBisCO large subunit-binding protein subunit beta, chloroplastic Source.124: DFBPPR15994 ---- Animal proteins ---- Inactive pancreatic lipase-related protein 1 Source.125: DFBPPR16131 ---- Animal proteins ---- Pyruvate kinase PKLR Source.126: DFBPPR16147 ---- Animal proteins ---- Telomerase reverse transcriptase Source.127: DFBPPR16195 ---- Animal proteins ---- Xylosyltransferase 1 Source.128: DFBPPR16220 ---- Animal proteins ---- Deoxyribonuclease-1 Source.129: DFBPPR16266 ---- Animal proteins ---- Beta-1 adrenergic receptor Source.130: DFBPPR16279 ---- Animal proteins ---- Galactokinase Source.131: DFBPPR16519 ---- Animal proteins ---- Palmitoyltransferase ZDHHC8 Source.132: DFBPPR16635 ---- Animal proteins ---- Corticoliberin Source.133: DFBPPR16782 ---- Animal proteins ---- Alcohol dehydrogenase 1 Source.134: DFBPPR16832 ---- Animal proteins ---- ATP synthase subunit alpha, mitochondrial Source.135: DFBPPR16973 ---- Animal proteins ---- Fatty acid synthase Source.136: DFBPPR17137 ---- Animal proteins ---- Interleukin-1 receptor-associated kinase 1 Source.137: DFBPPR17269 ---- Animal proteins ---- Phosphatidylinositol-glycan-specific phospholipase D Source.138: DFBPPR17316 ---- Animal proteins ---- Forkhead box protein O1 Source.139: DFBPPR17337 ---- Animal proteins ---- Polyunsaturated fatty acid lipoxygenase ALOX15 Source.140: DFBPPR17547 ---- Animal proteins ---- Cleavage and polyadenylation specificity factor subunit 5 Source.141: DFBPPR17622 ---- Animal proteins ---- Hairy/enhancer-of-split related with YRPW motif-like protein Source.142: DFBPPR17660 ---- Animal proteins ---- 5'-AMP-activated protein kinase subunit gamma-3 Source.143: DFBPPR17691 ---- Animal proteins ---- Integrin alpha-L Source.144: DFBPPR17735 ---- Animal proteins ---- Farnesyl pyrophosphate synthase Source.145: DFBPPR17927 ---- Animal proteins ---- Synaptojanin-1 Source.146: DFBPPR17947 ---- Animal proteins ---- Erythropoietin Source.147: DFBPPR17961 ---- Animal proteins ---- Cyclin-dependent kinase 12 Source.148: DFBPPR17972 ---- Animal proteins ---- Telomerase reverse transcriptase Source.149: DFBPPR17985 ---- Animal proteins ---- Unconventional prefoldin RPB5 interactor Source.150: DFBPPR18323 ---- Animal proteins ---- Transcription factor E2F7 Source.151: DFBPPR18396 ---- Animal proteins ---- Corticoliberin Source.152: DFBPPR18422 ---- Animal proteins ---- Endonuclease III-like protein 1 Source.153: DFBPPR18429 ---- Animal proteins ---- Pre-mRNA-splicing factor SLU7 Source.154: DFBPPR18479 ---- Animal proteins ---- Pyruvate dehydrogenase protein X component Source.155: DFBPPR18493 ---- Animal proteins ---- H(+)/Cl(-) exchange transporter 7 Source.156: DFBPPR18516 ---- Animal proteins ---- Galactokinase Source.157: DFBPPR18636 ---- Animal proteins ---- AP-2 complex subunit alpha-2 Source.158: DFBPPR18809 ---- Animal proteins ---- Adenylate kinase isoenzyme 5 Source.159: DFBPPR18864 ---- Animal proteins ---- 5'-AMP-activated protein kinase subunit gamma-1 Source.160: DFBPPR19180 ---- Animal proteins ---- Reticulocalbin-3 Source.161: DFBPPR19517 ---- Animal proteins ---- Nucleoredoxin Source.162: DFBPPR19619 ---- Animal proteins ---- PAXIP1-associated glutamate-rich protein 1 Source.163: DFBPPR19670 ---- Animal proteins ---- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Source.164: DFBPPR19721 ---- Animal proteins ---- G-protein coupled receptor 4 Source.165: DFBPPR19860 ---- Animal proteins ---- Transketolase-like protein 2 Source.166: DFBPPR19917 ---- Animal proteins ---- PH and SEC7 domain-containing protein 1 Source.167: DFBPPR20149 ---- Animal proteins ---- Flotillin-2 Source.168: DFBPPR20460 ---- Animal proteins ---- Monocarboxylate transporter 1 Source.169: DFBPPR20558 ---- Animal proteins ---- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Source.170: DFBPPR20665 ---- Animal proteins ---- PWWP domain-containing DNA repair factor 3A Source.171: DFBPPR20681 ---- Animal proteins ---- G-protein coupled bile acid receptor 1 Source.172: DFBPPR20823 ---- Animal proteins ---- Ubiquitin-related modifier 1 Source.173: DFBPPR20944 ---- Animal proteins ---- Pikachurin Source.174: DFBPPR21024 ---- Animal proteins ---- Glycosylated lysosomal membrane protein Source.175: DFBPPR21035 ---- Animal proteins ---- 39S ribosomal protein L38, mitochondrial Source.176: DFBPPR21057 ---- Animal proteins ---- KICSTOR complex protein ITFG2 Source.177: DFBPPR21096 ---- Animal proteins ---- Kinesin light chain 4 Source.178: DFBPPR21414 ---- Animal proteins ---- Neuromedin-B Source.179: DFBPPR21518 ---- Animal proteins ---- U6 snRNA phosphodiesterase Source.180: DFBPPR21569 ---- Animal proteins ---- Engulfment and cell motility protein 3 Source.181: DFBPPR21591 ---- Animal proteins ---- Homeobox protein aristaless-like 4 Source.182: DFBPPR21612 ---- Animal proteins ---- Probable inactive glycosyltransferase 25 family member 3 Source.183: DFBPPR21613 ---- Animal proteins ---- Probable inactive glycosyltransferase 25 family member 3 Source.184: DFBPPR21624 ---- Animal proteins ---- Docking protein 1 Source.185: DFBPPR21692 ---- Animal proteins ---- Mitotic-spindle organizing protein 2 Source.186: DFBPPR21742 ---- Animal proteins ---- Proteasomal ATPase-associated factor 1 Source.187: DFBPPR21762 ---- Animal proteins ---- Mediator of RNA polymerase II transcription subunit 28 Source.188: DFBPPR21799 ---- Animal proteins ---- Major vault protein Source.189: DFBPPR21819 ---- Animal proteins ---- Putative sodium-coupled neutral amino acid transporter 11 Source.190: DFBPPR21837 ---- Animal proteins ---- Zinc finger protein 750 Source.191: DFBPPR21921 ---- Animal proteins ---- AP-5 complex subunit beta-1 Source.192: DFBPPR22273 ---- Animal proteins ---- 39S ribosomal protein L45, mitochondrial Source.193: DFBPPR22331 ---- Animal proteins ---- Zinc finger SWIM domain-containing protein 8 Source.194: DFBPPR22742 ---- Animal proteins ---- Uncharacterized protein C12orf71 homolog Source.195: DFBPPR8543 ---- Animal proteins ---- Sterol regulatory element-binding protein 1 Source.196: DFBPPR8676 ---- Animal proteins ---- Platelet endothelial cell adhesion molecule Source.197: DFBPPR8776 ---- Animal proteins ---- Serine/threonine-protein kinase WNK1 Source.198: DFBPPR9010 ---- Animal proteins ---- 5'-AMP-activated protein kinase subunit gamma-3 Source.199: DFBPPR9014 ---- Animal proteins ---- ATP synthase subunit alpha, mitochondrial Source.200: DFBPPR9103 ---- Animal proteins ---- Beta-1 adrenergic receptor Source.201: DFBPPR9271 ---- Animal proteins ---- 5'-AMP-activated protein kinase subunit gamma-1 Source.202: DFBPPR9519 ---- Animal proteins ---- Granulocyte colony-stimulating factor Source.203: DFBPPR9776 ---- Animal proteins ---- Zinc finger protein PLAGL1 Source.204: DFBPPR9867 ---- Animal proteins ---- Phostensin Source.205: DFBPPR9956 ---- Animal proteins ---- Fatty acid synthase Source.206: DFBPPR10009 ---- Animal proteins ---- Transthyretin Source.207: DFBPPR10060 ---- Animal proteins ---- Alpha-N-acetylgalactosaminidase Source.208: DFBPPR10207 ---- Animal proteins ---- Paralemmin-1 Source.209: DFBPPR10342 ---- Animal proteins ---- Alcohol dehydrogenase 1 Source.210: DFBPPR10410 ---- Animal proteins ---- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Source.211: DFBPPR10560 ---- Animal proteins ---- E3 ubiquitin-protein ligase TRIM71 Source.212: DFBPPR10605 ---- Animal proteins ---- Elastin Source.213: DFBPPR10688 ---- Animal proteins ---- Protein S100-A6 Source.214: DFBPPR10753 ---- Animal proteins ---- Hypermethylated in cancer 1 protein Source.215: DFBPPR10857 ---- Animal proteins ---- Smoothened homolog Source.216: DFBPPR10969 ---- Animal proteins ---- Paraspeckle component 1 Source.217: DFBPPR11094 ---- Animal proteins ---- Transcription factor MafA Source.218: DFBPPR11120 ---- Animal proteins ---- Ephrin-B1 Source.219: DFBPPR11246 ---- Animal proteins ---- 5'-3' exoribonuclease 2 Source.220: DFBPPR11287 ---- Animal proteins ---- Lethal(3)malignant brain tumor-like protein 1 Source.221: DFBPPR11314 ---- Animal proteins ---- Multivesicular body subunit 12A Source.222: DFBPPR11343 ---- Animal proteins ---- Transcription factor Sp8 Source.223: DFBPPR11354 ---- Animal proteins ---- Centromere protein O Source.224: DFBPPR11405 ---- Animal proteins ---- Cadherin-related family member 1 Source.225: DFBPPR11474 ---- Animal proteins ---- KH homology domain-containing protein 4 Source.226: DFBPPR11529 ---- Animal proteins ---- Alpha-endosulfine Source.227: DFBPPR11531 ---- Animal proteins ---- Protein AATF Source.228: DFBPPR11540 ---- Animal proteins ---- Homeobox protein MIXL1 Source.229: DFBPPR11780 ---- Animal proteins ---- Sister chromatid cohesion protein PDS5 homolog B Source.230: DFBPPR11845 ---- Animal proteins ---- Zinc finger and BTB domain-containing protein 17 Source.231: DFBPPR11871 ---- Animal proteins ---- RAD51-associated protein 1 Source.232: DFBPPR11920 ---- Animal proteins ---- Transcription initiation factor TFIID subunit 2 Source.233: DFBPPR11947 ---- Animal proteins ---- Transcription factor SOX-8 Source.234: DFBPPR11982 ---- Animal proteins ---- Transcription termination factor 3, mitochondrial Source.235: DFBPPR11984 ---- Animal proteins ---- SET and MYND domain-containing protein 4 Source.236: DFBPPR12017 ---- Animal proteins ---- Zinc finger protein CKR1 Source.237: DFBPPR12149 ---- Animal proteins ---- Major vault protein Source.238: DFBPPR12173 ---- Animal proteins ---- Protein CIP2A homolog Source.239: DFBPPR12254 ---- Animal proteins ---- Cytochrome P450 1A2 Source.240: DFBPPR12257 ---- Animal proteins ---- Polyunsaturated fatty acid lipoxygenase ALOX15 Source.241: DFBPPR12306 ---- Animal proteins ---- Sodium/glucose cotransporter 1 Source.242: DFBPPR12421 ---- Animal proteins ---- Arylacetamide deacetylase Source.243: DFBPPR12470 ---- Animal proteins ---- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Source.244: DFBPPR12499 ---- Animal proteins ---- Interleukin-1 alpha Source.245: DFBPPR12607 ---- Animal proteins ---- Basigin Source.246: DFBPPR12749 ---- Animal proteins ---- Alcohol dehydrogenase 1 Source.247: DFBPPR12784 ---- Animal proteins ---- Cadherin-16 Source.248: DFBPPR13024 ---- Animal proteins ---- Erythropoietin Source.249: DFBPPR13094 ---- Animal proteins ---- Atherin Source.250: DFBPPR13358 ---- Animal proteins ---- Erythropoietin Source.251: DFBPPR13513 ---- Animal proteins ---- Ubiquitin-related modifier 1 Source.252: DFBPPR13627 ---- Animal proteins ---- Erythropoietin Source.253: DFBPPR13654 ---- Animal proteins ---- Corticoliberin Source.254: DFBPPR13894 ---- Animal proteins ---- Brain-enriched guanylate kinase-associated protein Source.255: DFBPPR14339 ---- Marine protein ---- Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein Source.256: DFBPPR14387 ---- Marine protein ---- Photosystem II 12 kDa extrinsic protein, chloroplastic Source.257: DFBPPR14800 ---- Marine protein ---- Crustacyanin-A1 subunit Source.258: DFBPPR14804 ---- Marine protein ---- Crustacyanin-C1 subunit Source.259: DFBPPR14960 ---- Microorganism protein ---- Protease KEX1 Source.260: DFBPPR14972 ---- Microorganism protein ---- ATP synthase subunit alpha, mitochondrial Source.261: DFBPPR14991 ---- Microorganism protein ---- Actin cytoskeleton-regulatory complex protein PAN1 Source.262: DFBPPR15397 ---- Microorganism protein ---- Nucleolar GTP-binding protein 2 Source.263: DFBPPR15677 ---- Microorganism protein ---- Ribosome-recycling factor, mitochondrial Source.264: DFBPPR15699 ---- Microorganism protein ---- Meiotic sister-chromatid recombination protein 3 Source.265: DFBPPR15860 ---- Microorganism protein ---- ATP synthase subunit delta, mitochondrial Source.266: DFBPPR7756 ---- Plant protein ---- P-(S)-hydroxymandelonitrile lyase Source.267: DFBPPR7760 ---- Plant protein ---- Tyrosine N-monooxygenase Source.268: DFBPPR7871 ---- Plant protein ---- Casparian strip membrane protein 3 Source.269: DFBPPR7892 ---- Plant protein ---- CASP-like protein 2A1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

ACE-inhibitory activity	The peptide exhibited very low Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) inhibitory activity with an IC₅₀ value of > 1000 uM.
Specific target protein(s)	Specific Target Protein(s): Angiotensin-converting enzyme

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	The precursor peptide AAPLAP originating from dry-cured ham was absorpted by Caco-2 cell line, and then generated the ACE inhibitory peptide fragment AAPL.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

This study highlights the potential of intact dry-cured ham peptides as well as their fragments to be absorbed across the intestinal epithelium and reach the blood stream to exert an antihypertensive action.

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Gallego, M., Grootaert, C., Mora, L., Aristoy, M.C., Van Camp, J., Toldrá, F. Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-2 cell monolayer. Journal of Functional Foods. 2016, 21, 388-95. DOI: 10.1016/j.jff.2015.11.046
Other literature(s)	N.D
PubDate	2016