DFBP ID - DFBPACEI2228(ACE-inhibitory peptide)

DFBP ID DFBPACEI2228 Peptide sequence GRVSNCAA Type Native peptide Peptide/Function name ACE-inhibitory peptide

Function-activity relationship

Main bioactivity ACE-inhibitory activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Gly-Arg-Val-Ser-Asn-Cys-Ala-Ala Single-letter amino acid GRVSNCAA Peptide length 8 Peptide mass Experimental mass Theoretical mass N.D 776.86 Da c Net charge 0.00 c Isoelectric point (pI) 8.93 c IC50 57.93 μmol/L pIC50 -1.763 GRAVY 0.1375 c Hydrophilic residue ratio 50% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Ruditapes philippinarum Precursor protein Umami peptides Residue position N.D Precursor protein(s) search No matching precursor protein found Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

ACE-inhibitory activity GRVSNCAA had 90.72% activity and 88.37% activity after digestion. Specific target protein(s) Specific Target Protein(s): Angiotensin-converting enzyme

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Non-bitter taste prediction SMILES N.D

Preparation method

Mode of preparation N.D Enzyme(s)/starter culture N.D

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information Some umami peptides have the potential to provide human health benefits.

Database cross-references

BIOPEP-UWM [D1] -

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Yue Z A , Dpa B , Zy D , et al. Angiotensin I-Converting Enzyme (ACE) Inhibitory and Dipeptidyl Peptidase-4 (DPP-Ⅳ) Inhibitory Activity of Umami Peptides from Ruditapes philippinarum[J]. LWT, 2021. DOI: 10.1016/j.lwt.2021.111265 Other literature(s) N.D PubDate 2021