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List of peptide properties
DFBP ID - DFBPAGPE0001(Alpha-gliadin peptide)
DFBP ID DFBPAGPE0001
Peptide sequence PSQQQP
Type Native peptide
Peptide/Function name α-Gliadin peptide, Coeliac toxic peptide
Function-activity relationship
Main bioactivity Coeliac toxic activity
Otheir bioactivity N.D
Calculated physicochemical properties
Three-letter amino acid Pro-Ser-Gln-Gln-Gln-Pro
Single-letter amino acid PSQQQP
Peptide length 6
Peptide mass
Experimental mass Theoretical mass
683.7070 Da 683.72 Da c
Net charge 0.00 c
Isoelectric point (pI) 5.97 c
IC50 N.D
pIC50 N.D
GRAVY -2.4167 c
Hydrophilic residue ratio 33.33% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Plant
Organism/Source Wheat gluten
Precursor protein α-Gliadin
Residue position N.D
Precursor protein(s) search
Source.1: DFBPPR0379 ---- Plant protein ---- Alpha-gliadin
Source.2: DFBPPR0380 ---- Plant protein ---- Alpha-gliadin
Source.3: DFBPPR0381 ---- Plant protein ---- Alpha-gliadin
Source.4: DFBPPR0382 ---- Plant protein ---- Alpha-gliadin
Source.5: DFBPPR0383 ---- Plant protein ---- Alpha-gliadin
Source.6: DFBPPR0384 ---- Plant protein ---- Alpha-gliadin
Source.7: DFBPPR0385 ---- Plant protein ---- Alpha-gliadin
Source.8: DFBPPR0388 ---- Plant protein ---- Low molecular weight glutenin subunit
Source.9: DFBPPR0389 ---- Plant protein ---- Alpha-gliadin
Source.10: DFBPPR0390 ---- Plant protein ---- B3144=ALPHA-gliadin derived CELIAC active peptide
Source.11: DFBPPR0391 ---- Plant protein ---- B3143=ALPHA-gliadin derived CELIAC active peptide
Source.12: DFBPPR6853 ---- Plant proteins ---- Alpha/beta-gliadin MM1
Source.13: DFBPPR6930 ---- Plant proteins ---- Alpha/beta-gliadin
Source.14: DFBPPR6936 ---- Plant proteins ---- Alpha/beta-gliadin A-II
Source.15: DFBPPR6937 ---- Plant proteins ---- Alpha/beta-gliadin A-IV
Source.16: DFBPPR6938 ---- Plant proteins ---- Alpha/beta-gliadin clone PW8142
Source.17: DFBPPR6939 ---- Plant proteins ---- Alpha/beta-gliadin A-V
Source.18: DFBPPR6940 ---- Plant proteins ---- Alpha/beta-gliadin A-III
Source.19: DFBPPR6941 ---- Plant proteins ---- Alpha/beta-gliadin A-I
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Coeliac toxic activity

The peptide was toxicity to patients with coeliac disease. The tests showed that digestion products from patients coeliac mucoas caused damage to rat liver lysosomes in contrast to digestion products from normal mucosa which had practically no effects on the lysosomes (Mean activity was 31%, means of two results, expressed as % reduction in absorbance compared with zero-time tubes).

Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Non-bitter taste prediction
SMILES N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O
Preparation method
Mode of preparation

Enzymatic hydrolysis

Enzyme(s)/starter culture

The peptide was obtained by peptic-tryptic-pancreatinic digest of wheat gliadin.

Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
BIOPEP-UWM [D1] 2578
APD [D2] -
BioPepDB [D3] -
MBPDB [D4] -
Reference(s)
Primary literature Cornell HJ. Amino acid composition of peptides remaining after in vitro digestion of a gliadin sub-fraction with duodenal mucosa from patients with coeliac disease. Clin Chim Acta. 1988 Sep 15;176(3):279-89.
PMID: 3180479
Other literature(s) N.D
PubDate 1988
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