Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPAGPE0013(Alpha-gliadin peptide)

DFBP ID	DFBPAGPE0013
Peptide sequence	QQPY
Type	Native peptide
Peptide/Function name	α-Gliadin peptide, Coeliac toxic peptide

Function-activity relationship

Main bioactivity	Alpha-gliadin peptide activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Gln-Gln-Pro-Tyr

Single-letter amino acid

QQPY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
534.5490 Da	534.57 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.92 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.4750^c

Hydrophilic residue ratio

25%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Wheat
Precursor protein	α-Gliadin
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0379 ---- Plant protein ---- Alpha-gliadin Source.2: DFBPPR0380 ---- Plant protein ---- Alpha-gliadin Source.3: DFBPPR0381 ---- Plant protein ---- Alpha-gliadin Source.4: DFBPPR0382 ---- Plant protein ---- Alpha-gliadin Source.5: DFBPPR0383 ---- Plant protein ---- Alpha-gliadin Source.6: DFBPPR0384 ---- Plant protein ---- Alpha-gliadin Source.7: DFBPPR0385 ---- Plant protein ---- Alpha-gliadin Source.8: DFBPPR0389 ---- Plant protein ---- Alpha-gliadin Source.9: DFBPPR0390 ---- Plant protein ---- B3144=ALPHA-gliadin derived CELIAC active peptide Source.10: DFBPPR0391 ---- Plant protein ---- B3143=ALPHA-gliadin derived CELIAC active peptide Source.11: DFBPPR4014 ---- Plant proteins ---- Probable high-affinity nitrate transporter-activating protein 2.2 Source.12: DFBPPR4578 ---- Plant proteins ---- Protein argonaute 1D Source.13: DFBPPR5085 ---- Plant proteins ---- Pyruvate kinase, cytosolic isozyme Source.14: DFBPPR5601 ---- Plant proteins ---- Protein HIRA Source.15: DFBPPR6082 ---- Plant proteins ---- Zein-alpha 19D1 Source.16: DFBPPR6853 ---- Plant proteins ---- Alpha/beta-gliadin MM1 Source.17: DFBPPR6930 ---- Plant proteins ---- Alpha/beta-gliadin Source.18: DFBPPR6934 ---- Plant proteins ---- Alpha/beta-gliadin clone PW1215 Source.19: DFBPPR6936 ---- Plant proteins ---- Alpha/beta-gliadin A-II Source.20: DFBPPR6937 ---- Plant proteins ---- Alpha/beta-gliadin A-IV Source.21: DFBPPR6938 ---- Plant proteins ---- Alpha/beta-gliadin clone PW8142 Source.22: DFBPPR6939 ---- Plant proteins ---- Alpha/beta-gliadin A-V Source.23: DFBPPR6940 ---- Plant proteins ---- Alpha/beta-gliadin A-III Source.24: DFBPPR6941 ---- Plant proteins ---- Alpha/beta-gliadin A-I Source.25: DFBPPR6960 ---- Plant proteins ---- Gamma-gliadin Source.26: DFBPPR6965 ---- Plant proteins ---- Gamma-gliadin B Source.27: DFBPPR7265 ---- Plant proteins ---- Gamma-hordein-3 Source.28: DFBPPR7315 ---- Plant proteins ---- Gamma-hordein-1 Source.29: DFBPPR15979 ---- Animal proteins ---- Serine/threonine-protein kinase NLK Source.30: DFBPPR17045 ---- Animal proteins ---- Oxysterols receptor LXR-beta Source.31: DFBPPR17053 ---- Animal proteins ---- Junction plakoglobin Source.32: DFBPPR17941 ---- Animal proteins ---- Hepatocyte growth factor-regulated tyrosine kinase substrate Source.33: DFBPPR17961 ---- Animal proteins ---- Cyclin-dependent kinase 12 Source.34: DFBPPR18320 ---- Animal proteins ---- Serine/threonine-protein kinase NLK Source.35: DFBPPR18780 ---- Animal proteins ---- Homeobox protein Hox-A3 Source.36: DFBPPR19850 ---- Animal proteins ---- Protein YIPF5 Source.37: DFBPPR20235 ---- Animal proteins ---- Gamma-crystallin A Source.38: DFBPPR20389 ---- Animal proteins ---- Leucine-rich repeat-containing protein 7 Source.39: DFBPPR20477 ---- Animal proteins ---- PAX-interacting protein 1 Source.40: DFBPPR20521 ---- Animal proteins ---- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Source.41: DFBPPR20532 ---- Animal proteins ---- LIM/homeobox protein Lhx9 Source.42: DFBPPR9250 ---- Animal proteins ---- Junction plakoglobin Source.43: DFBPPR10147 ---- Animal proteins ---- Proto-oncogene tyrosine-protein kinase ROS Source.44: DFBPPR10457 ---- Animal proteins ---- Transcriptional enhancer factor TEF-3 Source.45: DFBPPR10512 ---- Animal proteins ---- Collagen alpha-1(XIV) chain Source.46: DFBPPR11344 ---- Animal proteins ---- LIM/homeobox protein Lhx9 Source.47: DFBPPR11711 ---- Animal proteins ---- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Source.48: DFBPPR12468 ---- Animal proteins ---- Zona pellucida sperm-binding protein 2 Source.49: DFBPPR14973 ---- Microorganism protein ---- Lon protease homolog, mitochondrial Source.50: DFBPPR15174 ---- Microorganism protein ---- ATP-dependent rRNA helicase RRP3 Source.51: DFBPPR15215 ---- Microorganism protein ---- Protein transport protein SEC24
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Coeliac toxic activity	Celiac toxic
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	No prediction can be made about the peptide bitterness. ^prediction

SMILES

N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation	null
Enzyme(s)/starter culture	null

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

Coeliac disease is a permanent intolerance to the gluten or storage proteins found in some cereals. According to De Ritis and coworkers, small sequences of amino acids are common to the peptides linked with the toxicity. It has also been suggested that Tyr-containing motif is also associated with toxicity.
Peptide derived from apha-gliadin.

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	McLachlan A, Cullis PG, Cornell HJ. The use of extended amino acid motifs for focussing on toxic peptides in coeliac disease. J Biochem Mol Biol Biophys. 2002 Oct;6(5):319-24. PMID: 12385967 DOI: 10.1080/1025814021000003238
Other literature(s)	N.D
PubDate	2002