Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPAGPE0014(Alpha-gliadin peptide)

DFBP ID	DFBPAGPE0014
Peptide sequence	QPYP
Type	Native peptide
Peptide/Function name	α-Gliadin peptide, Coeliac toxic peptide

Function-activity relationship

Main bioactivity	Alpha-gliadin peptide activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Gln-Pro-Tyr-Pro

Single-letter amino acid

QPYP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
503.5350 Da	503.55 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.92 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.0000^c

Hydrophilic residue ratio

50%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Wheat
Precursor protein	α-Gliadin
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0379 ---- Plant protein ---- Alpha-gliadin Source.2: DFBPPR0380 ---- Plant protein ---- Alpha-gliadin Source.3: DFBPPR0381 ---- Plant protein ---- Alpha-gliadin Source.4: DFBPPR0382 ---- Plant protein ---- Alpha-gliadin Source.5: DFBPPR0383 ---- Plant protein ---- Alpha-gliadin Source.6: DFBPPR0384 ---- Plant protein ---- Alpha-gliadin Source.7: DFBPPR0385 ---- Plant protein ---- Alpha-gliadin Source.8: DFBPPR0389 ---- Plant protein ---- Alpha-gliadin Source.9: DFBPPR0390 ---- Plant protein ---- B3144=ALPHA-gliadin derived CELIAC active peptide Source.10: DFBPPR0391 ---- Plant protein ---- B3143=ALPHA-gliadin derived CELIAC active peptide Source.11: DFBPPR2280 ---- Plant proteins ---- Origin of replication complex subunit 3 Source.12: DFBPPR2429 ---- Plant proteins ---- Multicopper oxidase LPR1 homolog 5 Source.13: DFBPPR2609 ---- Plant proteins ---- Auxin response factor 15 Source.14: DFBPPR3322 ---- Plant proteins ---- Putative xyloglucan glycosyltransferase 10 Source.15: DFBPPR5765 ---- Plant proteins ---- Homeobox protein HOX1A Source.16: DFBPPR6853 ---- Plant proteins ---- Alpha/beta-gliadin MM1 Source.17: DFBPPR6930 ---- Plant proteins ---- Alpha/beta-gliadin Source.18: DFBPPR6934 ---- Plant proteins ---- Alpha/beta-gliadin clone PW1215 Source.19: DFBPPR6936 ---- Plant proteins ---- Alpha/beta-gliadin A-II Source.20: DFBPPR6937 ---- Plant proteins ---- Alpha/beta-gliadin A-IV Source.21: DFBPPR6938 ---- Plant proteins ---- Alpha/beta-gliadin clone PW8142 Source.22: DFBPPR6939 ---- Plant proteins ---- Alpha/beta-gliadin A-V Source.23: DFBPPR6940 ---- Plant proteins ---- Alpha/beta-gliadin A-III Source.24: DFBPPR6941 ---- Plant proteins ---- Alpha/beta-gliadin A-I Source.25: DFBPPR6960 ---- Plant proteins ---- Gamma-gliadin Source.26: DFBPPR6965 ---- Plant proteins ---- Gamma-gliadin B Source.27: DFBPPR7265 ---- Plant proteins ---- Gamma-hordein-3 Source.28: DFBPPR7311 ---- Plant proteins ---- B1-hordein Source.29: DFBPPR7315 ---- Plant proteins ---- Gamma-hordein-1 Source.30: DFBPPR7318 ---- Plant proteins ---- B3-hordein Source.31: DFBPPR7335 ---- Plant proteins ---- C-hordein Source.32: DFBPPR7725 ---- Plant proteins ---- Avenin-3 Source.33: DFBPPR7739 ---- Plant proteins ---- Avenin-E Source.34: DFBPPR7741 ---- Plant proteins ---- Avenin-F Source.35: DFBPPR7742 ---- Plant proteins ---- Avenin-A Source.36: DFBPPR7749 ---- Plant proteins ---- Avenin Source.37: DFBPPR16108 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Source.38: DFBPPR16232 ---- Animal proteins ---- Lysine-specific demethylase 5D Source.39: DFBPPR16696 ---- Animal proteins ---- von Hippel-Lindau disease tumor suppressor Source.40: DFBPPR17289 ---- Animal proteins ---- Receptor-interacting serine/threonine-protein kinase 2 Source.41: DFBPPR17330 ---- Animal proteins ---- Unconventional myosin-X Source.42: DFBPPR18240 ---- Animal proteins ---- Dual specificity protein kinase CLK3 Source.43: DFBPPR18619 ---- Animal proteins ---- Ras-related protein Rab-7b Source.44: DFBPPR18780 ---- Animal proteins ---- Homeobox protein Hox-A3 Source.45: DFBPPR19065 ---- Animal proteins ---- Cadherin-6 Source.46: DFBPPR20477 ---- Animal proteins ---- PAX-interacting protein 1 Source.47: DFBPPR20483 ---- Animal proteins ---- Thioredoxin-related transmembrane protein 1 Source.48: DFBPPR20521 ---- Animal proteins ---- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Source.49: DFBPPR20532 ---- Animal proteins ---- LIM/homeobox protein Lhx9 Source.50: DFBPPR20917 ---- Animal proteins ---- RNA binding protein fox-1 homolog 3 Source.51: DFBPPR21522 ---- Animal proteins ---- ATP-dependent RNA helicase DQX1 Source.52: DFBPPR22720 ---- Animal proteins ---- UPF0739 protein C1orf74 homolog Source.53: DFBPPR8613 ---- Animal proteins ---- Thyroglobulin Source.54: DFBPPR9140 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Source.55: DFBPPR10147 ---- Animal proteins ---- Proto-oncogene tyrosine-protein kinase ROS Source.56: DFBPPR11010 ---- Animal proteins ---- Alpha-actinin-4 Source.57: DFBPPR11344 ---- Animal proteins ---- LIM/homeobox protein Lhx9 Source.58: DFBPPR11711 ---- Animal proteins ---- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Source.59: DFBPPR11942 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Source.60: DFBPPR14365 ---- Marine protein ---- Phycobiliprotein ApcE Source.61: DFBPPR15201 ---- Microorganism protein ---- Acetyl-CoA hydrolase Source.62: DFBPPR15426 ---- Microorganism protein ---- tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 Source.63: DFBPPR15577 ---- Microorganism protein ---- Chromatin modification-related protein EAF7 Source.64: DFBPPR8185 ---- Plant protein ---- Uncharacterized basic polypeptide
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Coeliac toxic activity	Celiac toxic
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	null
Enzyme(s)/starter culture	null

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

Coeliac disease is a permanent intolerance to the gluten or storage proteins found in some cereals. According to De Ritis and coworkers, small sequences of amino acids are common to the peptides linked with the toxicity. It has also been suggested that Tyr-containing motif is also associated with toxicity.
Peptide derived from apha-gliadin.

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	McLachlan A, Cullis PG, Cornell HJ. The use of extended amino acid motifs for focussing on toxic peptides in coeliac disease. J Biochem Mol Biol Biophys. 2002 Oct;6(5):319-24. PMID: 12385967 DOI: 10.1080/1025814021000003238
Other literature(s)	N.D
PubDate	2002