E-mail:gzliang@cqu.edu.cn    Tel: (86)2365102507

List of peptide properties
DFBP ID - DFBPAGPE0234(Alpha-gliadin peptide)
DFBP ID DFBPAGPE0234
Peptide sequence VQQQQFPGQQQPFPPQQPYPQPQPFPSQQPY
Type Native peptide
Peptide/Function name α-Gliadin peptide, Coeliac toxic peptide
Function-activity relationship
Main bioactivity Alpha-gliadin peptide activity
Otheir bioactivity N.D
Calculated physicochemical properties
Three-letter amino acid Val-Gln-Gln-Gln-Gln-Phe-Pro-Gly-Gln-Gln-Gln-Pro-Phe-Pro-Pro-Gln-Gln-Pro-Tyr-Pro-Gln-Pro-Gln-Pro-Phe-Pro-Ser-Gln-Gln-Pro-Tyr
Single-letter amino acid VQQQQFPGQQQPFPPQQPYPQPQPFPSQQPY
Peptide length 31
Peptide mass
Experimental mass Theoretical mass
3666.0090 Da 3666.05 Da c
Net charge 0.00 c
Isoelectric point (pI) 5.87 c
IC50 N.D
pIC50 N.D
GRAVY -1.7000 c
Hydrophilic residue ratio 48.39% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Plant
Organism/Source Wheat
Precursor protein α-Gliadin
Residue position

f(25-55)

Precursor protein(s) search
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Coeliac toxic activity

Gliadin source peptide, position 25-55. Pure peptides were isolated from peptic-tryptic  digest of gliadin by different separation techniques. The breakdown  of the disulphide bonds in peptic-tryptic peptides by oxidation did nto diminish toxicity.

Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools No prediction can be made about the peptide bitterness. prediction
SMILES N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O
Preparation method
Mode of preparation null
Enzyme(s)/starter culture null
Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
BIOPEP-UWM [D1] 7462
APD [D2] -
BioPepDB [D3] -
MBPDB [D4] -
Reference(s)
Primary literature Stern M, Ciclitira PJ, van Eckert R, Feighery C, Janssen FW, Méndez E, Mothes T, Troncone R, Wieser H. Analysis and clinical effects of gluten in coeliac disease. Eur J Gastroenterol Hepatol. 2001 Jun;13(6):741-7.
PMID: 11434606
Other literature(s) N.D
PubDate 2001
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214