Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPAGPE0239(Alpha-gliadin peptide)

DFBP ID	DFBPAGPE0239
Peptide sequence	PQPQPFPSQQPY
Type	Native peptide
Peptide/Function name	α-Gliadin peptide, Coeliac toxic peptide

Function-activity relationship

Main bioactivity	Alpha-gliadin peptide activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Pro-Gln-Pro-Gln-Pro-Phe-Pro-Ser-Gln-Gln-Pro-Tyr

Single-letter amino acid

PQPQPFPSQQPY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
1413.5360 Da	1413.55 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.92 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-1.7750^c

Hydrophilic residue ratio

50%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Wheat
Precursor protein	α-Gliadin
Residue position	f(44-45)
Precursor protein(s) search	Source.1: DFBPPR0379 ---- Plant protein ---- Alpha-gliadin Source.2: DFBPPR0380 ---- Plant protein ---- Alpha-gliadin Source.3: DFBPPR0381 ---- Plant protein ---- Alpha-gliadin Source.4: DFBPPR0383 ---- Plant protein ---- Alpha-gliadin Source.5: DFBPPR0384 ---- Plant protein ---- Alpha-gliadin Source.6: DFBPPR0389 ---- Plant protein ---- Alpha-gliadin Source.7: DFBPPR0390 ---- Plant protein ---- B3144=ALPHA-gliadin derived CELIAC active peptide Source.8: DFBPPR0391 ---- Plant protein ---- B3143=ALPHA-gliadin derived CELIAC active peptide Source.9: DFBPPR6853 ---- Plant proteins ---- Alpha/beta-gliadin MM1 Source.10: DFBPPR6934 ---- Plant proteins ---- Alpha/beta-gliadin clone PW1215 Source.11: DFBPPR6936 ---- Plant proteins ---- Alpha/beta-gliadin A-II Source.12: DFBPPR6938 ---- Plant proteins ---- Alpha/beta-gliadin clone PW8142 Source.13: DFBPPR6939 ---- Plant proteins ---- Alpha/beta-gliadin A-V Source.14: DFBPPR6941 ---- Plant proteins ---- Alpha/beta-gliadin A-I
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Coeliac toxic activity	Synthetic peptide from alpha-gliadin, position 44-55.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation	null
Enzyme(s)/starter culture	null

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Stern M, Ciclitira PJ, van Eckert R, Feighery C, Janssen FW, Méndez E, Mothes T, Troncone R, Wieser H. Analysis and clinical effects of gluten in coeliac disease. Eur J Gastroenterol Hepatol. 2001 Jun;13(6):741-7. PMID: 11434606 DOI: 10.1097/00042737-200106000-00023
Other literature(s)	N.D
PubDate	2001