DFBP ID - DFBPAMIC0178(Antimicrobial peptide)

DFBP ID DFBPAMIC0178 Peptide sequence VVAPFPE Type Native peptide Peptide/Function name Antimicrobial peptide, 7

Function-activity relationship

Main bioactivity Antimicrobial activity Otheir bioactivity ACE-inhibitory activity [D1], Multifunctional activity [D2]

Calculated physicochemical properties

Three-letter amino acid Val-Val-Ala-Pro-Phe-Pro-Glu Single-letter amino acid VVAPFPE Peptide length 7 Peptide mass Experimental mass Theoretical mass N.D 757.88 Da c Net charge 0.00 c Isoelectric point (pI) 3.34 c IC50 N.D pIC50 N.D GRAVY 0.9000 c Hydrophilic residue ratio 85.71% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Caprine milk (cheese) Precursor protein αs1-Casein Residue position f(24-30) Precursor protein(s) search Source.1: DFBPPR7688 ---- Milk proteins ---- Alpha-S1-casein Source.2: DFBPPR7694 ---- Milk proteins ---- Alpha-S1-casein Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antimicrobial activity Antimicrobial activity Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture No enzyme

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPACEI1816 [D2] DFBPMUFU0538

BIOPEP-UWM [D3] -

APD [D4] -

BioPepDB [D5] -

MBPDB [D6] -

Reference(s)

Primary literature Rizzello CG, Losito I, Gobbetti M, Carbonara T, De Bari MD, Zambonin PG. Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. J Dairy Sci. 2005 Jul;88(7):2348-60. PMID: 15956298 DOI: 10.3168/jds.S0022-0302(05)72913-1 Other literature(s) [1] Park Y W. Bioactive Components in Milk and Dairy Products[M]. 2009. PubDate 2005