DFBP ID - DFBPAMIC0287(Antimicrobial peptide)

DFBP ID DFBPAMIC0287 Peptide sequence FKCRRWQWRMKKLGAPSITCVRRAFA Type Native peptide Peptide/Function name Antimicrobial peptide, f(17-42) of bovine lactoferrin

Function-activity relationship

Main bioactivity Antimicrobial activity Otheir bioactivity Heparin-binding activity [D1], Multifunctional activity [D2]

Calculated physicochemical properties

Three-letter amino acid Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe-Ala Single-letter amino acid FKCRRWQWRMKKLGAPSITCVRRAFA Peptide length 26 Peptide mass Experimental mass Theoretical mass N.D 3196.88 Da c Net charge 0.00 c Isoelectric point (pI) 12.34 c IC50 N.D pIC50 N.D GRAVY -0.4846 c Hydrophilic residue ratio 50% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Bovine Precursor protein Lactoferrin(LF) Residue position f(17-42) Precursor protein(s) search Source.1: DFBPPR8500 ---- Milk proteins ---- Lactotransferrin Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antimicrobial activity Antimicrobial activity Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools No prediction can be made about the peptide bitterness. prediction SMILES N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture No enzyme

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPHEBP0036 [D2] DFBPMUFU0708

BIOPEP-UWM [D3] 3743

APD [D4] -

BioPepDB [D5] -

MBPDB [D6] -

Reference(s)

Primary literature Dionysius DA, Milne JM. Antibacterial peptides of bovine lactoferrin: purification and characterization. J Dairy Sci. 1997 Apr;80(4):667-74. PMID: 9149961 DOI: 10.3168/jds.S0022-0302(97)75985-X Other literature(s) N.D PubDate 1997