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List of peptide properties
DFBP ID - DFBPAMIC0474(Antimicrobial peptide)
DFBP ID DFBPAMIC0474
Peptide sequence RWRSFFKKAAHRGKHVGKRARTHYLG
Type Native peptide
Peptide/Function name Antimicrobial peptide, Pleurocidin analogue from Pleuronectes americanus
Function-activity relationship
Main bioactivity Antimicrobial activity
Otheir bioactivity Haemolytic activity [D1], Multifunctional activity [D2]
Calculated physicochemical properties
Three-letter amino acid Arg-Trp-Arg-Ser-Phe-Phe-Lys-Lys-Ala-Ala-His-Arg-Gly-Lys-His-Val-Gly-Lys-Arg-Ala-Arg-Thr-His-Tyr-Leu-Gly
Single-letter amino acid RWRSFFKKAAHRGKHVGKRARTHYLG
Peptide length 26
Peptide mass
Experimental mass Theoretical mass
N.D 3151.67 Da c
Net charge 0.00 c
Isoelectric point (pI) 12.68 c
IC50 N.D
pIC50 N.D
GRAVY -1.2923 c
Hydrophilic residue ratio 42.31% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Animal, Marine, Fish
Organism/Source Winter flounder (Pleuronectes americanus)
Precursor protein Pleurocidin analog
Residue position N.D
Precursor protein(s) search
No matching precursor protein found
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Antimicrobial activity

The peptide showed effective antimicrobial and hemolytic activity.

Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Non-bitter taste prediction
SMILES N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)O
Preparation method
Mode of preparation Synthesis
Enzyme(s)/starter culture No enzyme
Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
DFBP
[D1] DFBPHAPE0024
[D2] DFBPMUFU0713
BIOPEP-UWM [D3] 7763, 7764
APD [D4] -
BioPepDB [D5] -
MBPDB [D6] -
Reference(s)
Primary literature Sung WS, Lee DG. Pleurocidin-derived antifungal peptides with selective membrane-disruption effect. Biochem Biophys Res Commun. 2008 May 9;369(3):858-61.
PMID: 18325325
Other literature(s) N.D
PubDate 2008
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214