DFBP ID - DFBPAMIC0491(Antimicrobial peptide)

DFBP ID DFBPAMIC0491 Peptide sequence FSDKIAK Type Native peptide Peptide/Function name Antimicrobial peptide

Function-activity relationship

Main bioactivity Antimicrobial activity Otheir bioactivity ACE-inhibitory activity [D1], Antioxidative activity [D2], Multifunctional activity [D3]

Calculated physicochemical properties

Three-letter amino acid Phe-Ser-Asp-Lys-Ile-Ala-Lys Single-letter amino acid FSDKIAK Peptide length 7 Peptide mass Experimental mass Theoretical mass N.D 807.93 Da c Net charge 0.00 c Isoelectric point (pI) 9.84 c IC50 N.D pIC50 N.D GRAVY -0.4286 c Hydrophilic residue ratio 42.86% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Bovine Precursor protein κ-Casein Residue position f(18-24) Precursor protein(s) search Source.1: DFBPPR8492 ---- Milk proteins ---- Kappa-casein Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antimicrobial activity Antimicrobial activity Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O

Preparation method

Mode of preparation Enzymatic hydrolysis Enzyme(s)/starter culture Peptide obtained by hydrolysis of bovine Kappa-casein by use of  pepsin.

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPACEI1720 [D2] DFBPANOX0717 [D3] DFBPMUFU0497

BIOPEP-UWM [D4] 8181, 8266

APD [D5] -

BioPepDB [D6] -

MBPDB [D7] -

Reference(s)

Primary literature López-Expósito I, Minervini F, Amigo L, Recio I. Identification of antibacterial peptides from bovine kappa-casein. J Food Prot. 2006 Dec;69(12):2992-7. PMID: 17186669 DOI: 10.4315/0362-028x-69.12.2992 Other literature(s) N.D PubDate 2006