Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANCA0023(Anticancer peptide)

DFBP ID	DFBPANCA0023
Peptide sequence	WPP
Type	Native peptide
Peptide/Function name	Anticancer peptide

Function-activity relationship

Main bioactivity	Anticancer activity
Otheir bioactivity	Antioxidative activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Trp-Pro-Pro

Single-letter amino acid

WPP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
398.44 Da	398.46 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.97 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-1.3667^c

Hydrophilic residue ratio

100%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Marine
Organism/Source	Blood clam (Tegillarca granosa)
Precursor protein	Blood clam (Tegillarca granosa) muscle protein hydrolysates
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0864 ---- Plant proteins ---- Growth-regulating factor 4 Source.2: DFBPPR0917 ---- Plant proteins ---- Ethylene receptor 2 Source.3: DFBPPR0928 ---- Plant proteins ---- Cytochrome P450 90B2 Source.4: DFBPPR0939 ---- Plant proteins ---- Protein argonaute MEL1 Source.5: DFBPPR0958 ---- Plant proteins ---- APETALA2-like protein 5 Source.6: DFBPPR0995 ---- Plant proteins ---- Transcription factor TDR Source.7: DFBPPR1072 ---- Plant proteins ---- Cytokinin dehydrogenase 2 Source.8: DFBPPR1383 ---- Plant proteins ---- Protein rough sheath 2 homolog Source.9: DFBPPR1509 ---- Plant proteins ---- Heat stress transcription factor A-2d Source.10: DFBPPR1518 ---- Plant proteins ---- GATA transcription factor 15 Source.11: DFBPPR1564 ---- Plant proteins ---- Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 15 Source.12: DFBPPR1570 ---- Plant proteins ---- MEIOTIC F-BOX protein MOF Source.13: DFBPPR1764 ---- Plant proteins ---- B3 domain-containing protein VP1 Source.14: DFBPPR1765 ---- Plant proteins ---- Transcription factor MYC2 Source.15: DFBPPR1767 ---- Plant proteins ---- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial Source.16: DFBPPR1811 ---- Plant proteins ---- Sulfhydryl oxidase 1 Source.17: DFBPPR1821 ---- Plant proteins ---- Homeobox-leucine zipper protein HOX1 Source.18: DFBPPR1826 ---- Plant proteins ---- Protein terminal ear1 homolog Source.19: DFBPPR1916 ---- Plant proteins ---- Protein PYRICULARIA ORYZAE RESISTANCE 21 Source.20: DFBPPR1917 ---- Plant proteins ---- Kinesin-like protein KIN-12A Source.21: DFBPPR2039 ---- Plant proteins ---- Protein MONOCULM 1 Source.22: DFBPPR2049 ---- Plant proteins ---- Auxin response factor 19 Source.23: DFBPPR2092 ---- Plant proteins ---- Transcription factor MYB80 Source.24: DFBPPR2189 ---- Plant proteins ---- Probable glucomannan 4-beta-mannosyltransferase 4 Source.25: DFBPPR2238 ---- Plant proteins ---- Probable glucomannan 4-beta-mannosyltransferase 2 Source.26: DFBPPR2287 ---- Plant proteins ---- Dof zinc finger protein 3 Source.27: DFBPPR2420 ---- Plant proteins ---- Probable transcription factor GLK1 Source.28: DFBPPR2588 ---- Plant proteins ---- Putative heat stress transcription factor B-4a Source.29: DFBPPR2591 ---- Plant proteins ---- Secretory carrier-associated membrane protein 1 Source.30: DFBPPR2630 ---- Plant proteins ---- Probable protein phosphatase 2C 34 Source.31: DFBPPR2748 ---- Plant proteins ---- Secretory carrier-associated membrane protein 6 Source.32: DFBPPR2752 ---- Plant proteins ---- Secretory carrier-associated membrane protein 5 Source.33: DFBPPR2804 ---- Plant proteins ---- Protein GIGANTEA Source.34: DFBPPR2869 ---- Plant proteins ---- Homeobox-leucine zipper protein HOX11 Source.35: DFBPPR2907 ---- Plant proteins ---- Chlorophyll synthase, chloroplastic Source.36: DFBPPR2912 ---- Plant proteins ---- Probable auxin efflux carrier component 3b Source.37: DFBPPR2962 ---- Plant proteins ---- Transcription factor PCF8 Source.38: DFBPPR3050 ---- Plant proteins ---- Inositol polyphosphate multikinase IPK2 Source.39: DFBPPR3112 ---- Plant proteins ---- Auxin-responsive protein IAA6 Source.40: DFBPPR3134 ---- Plant proteins ---- Secretory carrier-associated membrane protein 2 Source.41: DFBPPR3153 ---- Plant proteins ---- Auxin-responsive protein IAA11 Source.42: DFBPPR3155 ---- Plant proteins ---- Acyl transferase 1 Source.43: DFBPPR3188 ---- Plant proteins ---- Auxin-responsive protein IAA27 Source.44: DFBPPR3213 ---- Plant proteins ---- DEAD-box ATP-dependent RNA helicase 5 Source.45: DFBPPR3218 ---- Plant proteins ---- Probable lipoxygenase 6 Source.46: DFBPPR3219 ---- Plant proteins ---- Secretory carrier-associated membrane protein 4 Source.47: DFBPPR3283 ---- Plant proteins ---- Auxin-responsive protein IAA21 Source.48: DFBPPR3304 ---- Plant proteins ---- Probable indole-3-acetic acid-amido synthetase GH3.2 Source.49: DFBPPR3325 ---- Plant proteins ---- Secretory carrier-associated membrane protein 3 Source.50: DFBPPR3374 ---- Plant proteins ---- Auxin-responsive protein IAA19 Source.51: DFBPPR3382 ---- Plant proteins ---- Auxin-responsive protein IAA14 Source.52: DFBPPR3385 ---- Plant proteins ---- Auxin-responsive protein IAA18 Source.53: DFBPPR3386 ---- Plant proteins ---- Auxin-responsive protein IAA2 Source.54: DFBPPR3392 ---- Plant proteins ---- Auxin-responsive protein IAA9 Source.55: DFBPPR3393 ---- Plant proteins ---- Auxin-responsive protein IAA20 Source.56: DFBPPR3394 ---- Plant proteins ---- Auxin-responsive protein IAA7 Source.57: DFBPPR3400 ---- Plant proteins ---- Auxin-responsive protein IAA12 Source.58: DFBPPR3404 ---- Plant proteins ---- Auxin-responsive protein IAA3 Source.59: DFBPPR3405 ---- Plant proteins ---- Auxin-responsive protein IAA1 Source.60: DFBPPR3411 ---- Plant proteins ---- Auxin-responsive protein IAA15 Source.61: DFBPPR3485 ---- Plant proteins ---- Auxin-responsive protein IAA31 Source.62: DFBPPR3534 ---- Plant proteins ---- Cardiolipin synthase (CMP-forming), mitochondrial Source.63: DFBPPR3552 ---- Plant proteins ---- Auxin-responsive protein IAA4 Source.64: DFBPPR3581 ---- Plant proteins ---- Auxin-responsive protein IAA17 Source.65: DFBPPR3594 ---- Plant proteins ---- Auxin-responsive protein IAA10 Source.66: DFBPPR3595 ---- Plant proteins ---- Auxin-responsive protein IAA24 Source.67: DFBPPR3677 ---- Plant proteins ---- Auxin-responsive protein IAA25 Source.68: DFBPPR3695 ---- Plant proteins ---- Auxin-responsive protein IAA23 Source.69: DFBPPR3754 ---- Plant proteins ---- Auxin-responsive protein IAA30 Source.70: DFBPPR3782 ---- Plant proteins ---- Auxin-responsive protein IAA16 Source.71: DFBPPR3824 ---- Plant proteins ---- Auxin-responsive protein IAA22 Source.72: DFBPPR3849 ---- Plant proteins ---- Auxin-responsive protein IAA13 Source.73: DFBPPR3948 ---- Plant proteins ---- Probable anion transporter 5, chloroplastic Source.74: DFBPPR4073 ---- Plant proteins ---- Auxin-responsive protein IAA5 Source.75: DFBPPR4075 ---- Plant proteins ---- Villin-4 Source.76: DFBPPR4103 ---- Plant proteins ---- Probable serine acetyltransferase 4 Source.77: DFBPPR4135 ---- Plant proteins ---- Probable protein phosphatase 2C 31 Source.78: DFBPPR4202 ---- Plant proteins ---- Cyclin-D3-2 Source.79: DFBPPR4312 ---- Plant proteins ---- Protein SUPPRESSOR OF GENE SILENCING 3 homolog Source.80: DFBPPR4349 ---- Plant proteins ---- Pentatricopeptide repeat-containing protein PPR5 homolog, chloroplastic Source.81: DFBPPR4444 ---- Plant proteins ---- Formin-like protein 6 Source.82: DFBPPR4449 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 45 Source.83: DFBPPR4477 ---- Plant proteins ---- Formin-like protein 3 Source.84: DFBPPR4480 ---- Plant proteins ---- Formin-like protein 7 Source.85: DFBPPR4513 ---- Plant proteins ---- Protein SMAX1-like Source.86: DFBPPR4595 ---- Plant proteins ---- Tubby-like F-box protein 9 Source.87: DFBPPR4603 ---- Plant proteins ---- Tubby-like F-box protein 2 Source.88: DFBPPR4668 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 62 Source.89: DFBPPR4734 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 67 Source.90: DFBPPR4893 ---- Plant proteins ---- F-box/LRR-repeat MAX2 homolog Source.91: DFBPPR4951 ---- Plant proteins ---- Dehydration-responsive element-binding protein 1I Source.92: DFBPPR5044 ---- Plant proteins ---- Cytochrome c oxidase subunit 3 Source.93: DFBPPR5112 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain 1, chloroplastic Source.94: DFBPPR5113 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain 4, chloroplastic Source.95: DFBPPR5119 ---- Plant proteins ---- G2/mitotic-specific cyclin S13-6 Source.96: DFBPPR5125 ---- Plant proteins ---- G2/mitotic-specific cyclin S13-7 Source.97: DFBPPR5265 ---- Plant proteins ---- Auxin-induced protein AUX22 Source.98: DFBPPR5271 ---- Plant proteins ---- Auxin-induced protein AUX28 Source.99: DFBPPR5332 ---- Plant proteins ---- Nodulin-20a Source.100: DFBPPR5521 ---- Plant proteins ---- Single myb histone 1 Source.101: DFBPPR5626 ---- Plant proteins ---- Single myb histone 6 Source.102: DFBPPR5709 ---- Plant proteins ---- indolin-2-one monooxygenase Source.103: DFBPPR5719 ---- Plant proteins ---- Single myb histone 5 Source.104: DFBPPR5721 ---- Plant proteins ---- Single myb histone 2 Source.105: DFBPPR5767 ---- Plant proteins ---- Teosinte glume architecture 1 Source.106: DFBPPR5829 ---- Plant proteins ---- Protein SUPPRESSOR OF GENE SILENCING 3 homolog Source.107: DFBPPR5854 ---- Plant proteins ---- Retinoblastoma-related protein 3 Source.108: DFBPPR5958 ---- Plant proteins ---- Cytochrome c oxidase subunit 3 Source.109: DFBPPR6010 ---- Plant proteins ---- Teosinte glume architecture 1 Source.110: DFBPPR6055 ---- Plant proteins ---- 14 kDa zinc-binding protein Source.111: DFBPPR6150 ---- Plant proteins ---- Autonomous transposable element EN-1 mosaic protein Source.112: DFBPPR6364 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain 3C, chloroplastic Source.113: DFBPPR6373 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain 3A, chloroplastic Source.114: DFBPPR6382 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain, chloroplastic Source.115: DFBPPR6389 ---- Plant proteins ---- Auxin-induced protein IAA4 Source.116: DFBPPR6464 ---- Plant proteins ---- 50S ribosomal protein 5, chloroplastic Source.117: DFBPPR6490 ---- Plant proteins ---- Secretory carrier-associated membrane protein Source.118: DFBPPR6509 ---- Plant proteins ---- Auxin-induced protein IAA6 Source.119: DFBPPR6778 ---- Plant proteins ---- Cytochrome c oxidase subunit 3 Source.120: DFBPPR7452 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain, chloroplastic Source.121: DFBPPR7453 ---- Plant proteins ---- Ribulose bisphosphate carboxylase small chain F1, chloroplastic Source.122: DFBPPR7632 ---- Milk proteins ---- Receptor tyrosine-protein kinase erbB-4 Source.123: DFBPPR7721 ---- Plant proteins ---- Chlorophyll synthase, chloroplastic Source.124: DFBPPR16009 ---- Animal proteins ---- Platelet-derived growth factor subunit B Source.125: DFBPPR16293 ---- Animal proteins ---- Baculoviral IAP repeat-containing protein 3 Source.126: DFBPPR16321 ---- Animal proteins ---- Aggrecan core protein Source.127: DFBPPR16472 ---- Animal proteins ---- Beta-1,3-galactosyltransferase 4 Source.128: DFBPPR16535 ---- Animal proteins ---- Cobalamin binding intrinsic factor Source.129: DFBPPR16603 ---- Animal proteins ---- Prostaglandin E2 receptor EP1 subtype Source.130: DFBPPR16769 ---- Animal proteins ---- Growth hormone receptor Source.131: DFBPPR16835 ---- Animal proteins ---- Insulin Source.132: DFBPPR16963 ---- Animal proteins ---- Lysosomal alpha-glucosidase Source.133: DFBPPR16987 ---- Animal proteins ---- Aggrecan core protein Source.134: DFBPPR17018 ---- Animal proteins ---- Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Source.135: DFBPPR17119 ---- Animal proteins ---- Hyaluronidase-2 Source.136: DFBPPR17137 ---- Animal proteins ---- Interleukin-1 receptor-associated kinase 1 Source.137: DFBPPR17306 ---- Animal proteins ---- Nuclear receptor subfamily 1 group D member 1 Source.138: DFBPPR17315 ---- Animal proteins ---- Neurexin-1-beta Source.139: DFBPPR17344 ---- Animal proteins ---- Neurexin-1 Source.140: DFBPPR17419 ---- Animal proteins ---- Inositol 1,4,5-triphosphate receptor associated 1 Source.141: DFBPPR17485 ---- Animal proteins ---- B-cell antigen receptor complex-associated protein alpha chain Source.142: DFBPPR17595 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.143: DFBPPR17647 ---- Animal proteins ---- Histidine triad nucleotide-binding protein 1 Source.144: DFBPPR17679 ---- Animal proteins ---- Platelet-derived growth factor subunit A Source.145: DFBPPR17780 ---- Animal proteins ---- Acetylcholinesterase Source.146: DFBPPR17896 ---- Animal proteins ---- Lethal(2) giant larvae protein homolog 1 Source.147: DFBPPR17990 ---- Animal proteins ---- Nuclear factor erythroid 2-related factor 2 Source.148: DFBPPR18074 ---- Animal proteins ---- Beta-3 adrenergic receptor Source.149: DFBPPR18135 ---- Animal proteins ---- Dihydrofolate reductase Source.150: DFBPPR18446 ---- Animal proteins ---- 5,6-dihydroxyindole-2-carboxylic acid oxidase Source.151: DFBPPR18474 ---- Animal proteins ---- Peroxisomal carnitine O-octanoyltransferase Source.152: DFBPPR18751 ---- Animal proteins ---- Mothers against decapentaplegic homolog 4 Source.153: DFBPPR18822 ---- Animal proteins ---- Sterol regulatory element-binding protein cleavage-activating protein Source.154: DFBPPR19018 ---- Animal proteins ---- Interferon regulatory factor 5 Source.155: DFBPPR19074 ---- Animal proteins ---- Lysophosphatidic acid phosphatase type 6 Source.156: DFBPPR19180 ---- Animal proteins ---- Reticulocalbin-3 Source.157: DFBPPR19203 ---- Animal proteins ---- Mitochondrial inner membrane protease subunit 2 Source.158: DFBPPR19316 ---- Animal proteins ---- Histidine triad nucleotide-binding protein 2, mitochondrial Source.159: DFBPPR19340 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator Source.160: DFBPPR19360 ---- Animal proteins ---- KN motif and ankyrin repeat domain-containing protein 2 Source.161: DFBPPR19449 ---- Animal proteins ---- SCO-spondin Source.162: DFBPPR19492 ---- Animal proteins ---- Alpha-(1,3)-fucosyltransferase 4 Source.163: DFBPPR19497 ---- Animal proteins ---- G1/S-specific cyclin-E2 Source.164: DFBPPR19738 ---- Animal proteins ---- Translocator protein Source.165: DFBPPR19871 ---- Animal proteins ---- Deoxyribonuclease-2-alpha Source.166: DFBPPR19945 ---- Animal proteins ---- Protein maelstrom homolog Source.167: DFBPPR19969 ---- Animal proteins ---- Growth/differentiation factor 10 Source.168: DFBPPR20007 ---- Animal proteins ---- Histone-lysine N-methyltransferase SETMAR Source.169: DFBPPR20157 ---- Animal proteins ---- Hydroxyproline dehydrogenase Source.170: DFBPPR20244 ---- Animal proteins ---- Zinc finger FYVE domain-containing protein 26 Source.171: DFBPPR20253 ---- Animal proteins ---- Cysteine protease ATG4A Source.172: DFBPPR20276 ---- Animal proteins ---- Hsp90 co-chaperone Cdc37-like 1 Source.173: DFBPPR20349 ---- Animal proteins ---- Lysosomal protective protein Source.174: DFBPPR20353 ---- Animal proteins ---- Protein mago nashi homolog 2 Source.175: DFBPPR20406 ---- Animal proteins ---- 28S ribosomal protein S11, mitochondrial Source.176: DFBPPR20433 ---- Animal proteins ---- Interleukin-22 receptor subunit alpha-1 Source.177: DFBPPR20494 ---- Animal proteins ---- Protein mago nashi homolog Source.178: DFBPPR20616 ---- Animal proteins ---- Zinc transporter ZIP13 Source.179: DFBPPR20665 ---- Animal proteins ---- PWWP domain-containing DNA repair factor 3A Source.180: DFBPPR20693 ---- Animal proteins ---- Tetraspanin-12 Source.181: DFBPPR21203 ---- Animal proteins ---- Nuclear protein 2 Source.182: DFBPPR21232 ---- Animal proteins ---- Cerebellin-3 Source.183: DFBPPR21280 ---- Animal proteins ---- Tubulointerstitial nephritis antigen Source.184: DFBPPR21357 ---- Animal proteins ---- Secretory carrier-associated membrane protein 3 Source.185: DFBPPR21428 ---- Animal proteins ---- Protein LBH Source.186: DFBPPR21473 ---- Animal proteins ---- TRPM8 channel-associated factor 1 Source.187: DFBPPR21485 ---- Animal proteins ---- Proline-rich protein 14 Source.188: DFBPPR21554 ---- Animal proteins ---- Transcription factor 23 Source.189: DFBPPR21632 ---- Animal proteins ---- Apoptosis facilitator Bcl-2-like protein 14 Source.190: DFBPPR21679 ---- Animal proteins ---- Protein spinster homolog 1 Source.191: DFBPPR21959 ---- Animal proteins ---- DDB1- and CUL4-associated factor 16 Source.192: DFBPPR21985 ---- Animal proteins ---- Leucine-rich repeat-containing protein 14 Source.193: DFBPPR21994 ---- Animal proteins ---- Protein PET100 homolog, mitochondrial Source.194: DFBPPR22189 ---- Animal proteins ---- Zinc finger matrin-type protein 5 Source.195: DFBPPR22302 ---- Animal proteins ---- Protein angel homolog 2 Source.196: DFBPPR22405 ---- Animal proteins ---- Uncharacterized protein CXorf66 homolog Source.197: DFBPPR22517 ---- Animal proteins ---- F-box only protein 15 Source.198: DFBPPR22570 ---- Animal proteins ---- Outer dense fiber protein 3-like protein 1 Source.199: DFBPPR22586 ---- Animal proteins ---- Uncharacterized protein KIAA2012 homolog Source.200: DFBPPR22677 ---- Animal proteins ---- Uncharacterized protein CXorf49 homolog Source.201: DFBPPR22689 ---- Animal proteins ---- Protein FAM166B Source.202: DFBPPR22690 ---- Animal proteins ---- Proline-rich protein 19 Source.203: DFBPPR8986 ---- Animal proteins ---- LIM domain and actin-binding protein 1 Source.204: DFBPPR9212 ---- Animal proteins ---- Dihydrofolate reductase Source.205: DFBPPR9269 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.206: DFBPPR9344 ---- Animal proteins ---- Desmoglein-1 Source.207: DFBPPR9379 ---- Animal proteins ---- Secretory carrier-associated membrane protein 1 Source.208: DFBPPR9419 ---- Animal proteins ---- Deoxyribonuclease-2-alpha Source.209: DFBPPR9560 ---- Animal proteins ---- Protein maelstrom homolog Source.210: DFBPPR9610 ---- Animal proteins ---- Solute carrier family 22 member 1 Source.211: DFBPPR9650 ---- Animal proteins ---- Muellerian-inhibiting factor Source.212: DFBPPR9784 ---- Animal proteins ---- Translocator protein Source.213: DFBPPR9877 ---- Animal proteins ---- Probable UDP-sugar transporter protein SLC35A4 Source.214: DFBPPR9912 ---- Animal proteins ---- Protein PET100 homolog, mitochondrial Source.215: DFBPPR9970 ---- Animal proteins ---- Growth hormone receptor Source.216: DFBPPR9997 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator-like protein 1 Source.217: DFBPPR10006 ---- Animal proteins ---- Toll-like receptor 2 type-1 Source.218: DFBPPR10076 ---- Animal proteins ---- Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Source.219: DFBPPR10141 ---- Animal proteins ---- Chondroitin sulfate proteoglycan 5 Source.220: DFBPPR10185 ---- Animal proteins ---- Unconventional myosin-Ia Source.221: DFBPPR10212 ---- Animal proteins ---- Gamma-aminobutyric acid receptor subunit gamma-4 Source.222: DFBPPR10229 ---- Animal proteins ---- Phosphoinositide 3-kinase adapter protein 1 Source.223: DFBPPR10293 ---- Animal proteins ---- Toll-like receptor 2 type-2 Source.224: DFBPPR10442 ---- Animal proteins ---- Neurexin-1 Source.225: DFBPPR10463 ---- Animal proteins ---- Sulfhydryl oxidase 1 Source.226: DFBPPR10507 ---- Animal proteins ---- Neurexin-1-beta Source.227: DFBPPR10694 ---- Animal proteins ---- Dihydrofolate reductase Source.228: DFBPPR10699 ---- Animal proteins ---- Acetylcholinesterase Source.229: DFBPPR10731 ---- Animal proteins ---- Protein cereblon Source.230: DFBPPR10798 ---- Animal proteins ---- 5,6-dihydroxyindole-2-carboxylic acid oxidase Source.231: DFBPPR10809 ---- Animal proteins ---- Lysine-specific demethylase 3A Source.232: DFBPPR10855 ---- Animal proteins ---- Transcription factor SOX-3 Source.233: DFBPPR10857 ---- Animal proteins ---- Smoothened homolog Source.234: DFBPPR10887 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.235: DFBPPR11085 ---- Animal proteins ---- Putative oxidoreductase GLYR1 Source.236: DFBPPR11106 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator-like protein 2 Source.237: DFBPPR11146 ---- Animal proteins ---- Formin Source.238: DFBPPR11272 ---- Animal proteins ---- Iroquois-class homeodomain protein IRX-4 Source.239: DFBPPR11348 ---- Animal proteins ---- Probable ATP-dependent RNA helicase DDX10 Source.240: DFBPPR11530 ---- Animal proteins ---- Probable cation-transporting ATPase 13A4 Source.241: DFBPPR11540 ---- Animal proteins ---- Homeobox protein MIXL1 Source.242: DFBPPR11541 ---- Animal proteins ---- Tetraspanin-12 Source.243: DFBPPR11595 ---- Animal proteins ---- Histone-lysine N-methyltransferase SETD1B Source.244: DFBPPR11611 ---- Animal proteins ---- Potassium channel subfamily T member 1 Source.245: DFBPPR11666 ---- Animal proteins ---- Interferon regulatory factor 2 Source.246: DFBPPR11727 ---- Animal proteins ---- Peroxisomal targeting signal 1 receptor Source.247: DFBPPR11826 ---- Animal proteins ---- Protein mago nashi homolog Source.248: DFBPPR11894 ---- Animal proteins ---- Centromere protein K Source.249: DFBPPR11899 ---- Animal proteins ---- Protein ILRUN Source.250: DFBPPR11909 ---- Animal proteins ---- Cysteine protease ATG4A Source.251: DFBPPR12020 ---- Animal proteins ---- Lipase maturation factor 2 Source.252: DFBPPR12112 ---- Animal proteins ---- Protein LBH Source.253: DFBPPR12113 ---- Animal proteins ---- Protein DENND6A Source.254: DFBPPR12300 ---- Animal proteins ---- Platelet-derived growth factor subunit A Source.255: DFBPPR12310 ---- Animal proteins ---- Voltage-dependent L-type calcium channel subunit alpha-1C Source.256: DFBPPR12321 ---- Animal proteins ---- Voltage-dependent N-type calcium channel subunit alpha-1B Source.257: DFBPPR12333 ---- Animal proteins ---- Angiogenin Source.258: DFBPPR12357 ---- Animal proteins ---- Galactoside alpha-(1,2)-fucosyltransferase 1 Source.259: DFBPPR12358 ---- Animal proteins ---- Histidine triad nucleotide-binding protein 1 Source.260: DFBPPR12396 ---- Animal proteins ---- Voltage-dependent P/Q-type calcium channel subunit alpha-1A Source.261: DFBPPR12422 ---- Animal proteins ---- Voltage-dependent R-type calcium channel subunit alpha-1E Source.262: DFBPPR12553 ---- Animal proteins ---- Anti-Muellerian hormone type-2 receptor Source.263: DFBPPR12743 ---- Animal proteins ---- Katanin p60 ATPase-containing subunit A-like 1 Source.264: DFBPPR12773 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator Source.265: DFBPPR12786 ---- Animal proteins ---- Intercellular adhesion molecule 5 Source.266: DFBPPR12838 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.267: DFBPPR12870 ---- Animal proteins ---- Protein transport protein Sec16B Source.268: DFBPPR13165 ---- Animal proteins ---- Aryl hydrocarbon receptor nuclear translocator-like protein 1 Source.269: DFBPPR13304 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.270: DFBPPR13451 ---- Animal proteins ---- Beta-3 adrenergic receptor Source.271: DFBPPR13536 ---- Animal proteins ---- Hyaluronidase-2 Source.272: DFBPPR13546 ---- Animal proteins ---- Platelet-derived growth factor subunit B Source.273: DFBPPR13578 ---- Animal proteins ---- Nuclear receptor subfamily 1 group D member 1 Source.274: DFBPPR13634 ---- Animal proteins ---- Beta-3 adrenergic receptor Source.275: DFBPPR13675 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.276: DFBPPR13826 ---- Animal proteins ---- Translocator protein Source.277: DFBPPR14015 ---- Animal proteins ---- Cytochrome c oxidase subunit 3 Source.278: DFBPPR14119 ---- Marine protein ---- Cytochrome c oxidase subunit 3 Source.279: DFBPPR14142 ---- Marine protein ---- Apolipoprotein A-I Source.280: DFBPPR14165 ---- Marine protein ---- Protein mago nashi homolog Source.281: DFBPPR14539 ---- Marine protein ---- Aryl hydrocarbon receptor nuclear translocator Source.282: DFBPPR14565 ---- Marine protein ---- Estrogen receptor beta Source.283: DFBPPR14627 ---- Marine protein ---- Cytochrome c oxidase subunit 3 Source.284: DFBPPR14913 ---- Microorganism protein ---- Serine/threonine-protein kinase CBK1 Source.285: DFBPPR15144 ---- Microorganism protein ---- Palmitoyltransferase PFA4 Source.286: DFBPPR15341 ---- Microorganism protein ---- Cytochrome c oxidase subunit 3 Source.287: DFBPPR15497 ---- Microorganism protein ---- Translocation protein SEC62 Source.288: DFBPPR15782 ---- Microorganism protein ---- Uncharacterized killer plasmid pGKl-2 protein 3 Source.289: DFBPPR7952 ---- Plant protein ---- Cytochrome c oxidase subunit 3 Source.290: DFBPPR8238 ---- Plant protein ---- Ribulose bisphosphate carboxylase small chain, chloroplastic Source.291: DFBPPR8274 ---- Plant protein ---- Cytochrome c oxidase subunit 3
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Anticancer activity

The peptide Trp-Pro-Pro showed strong cytotoxicity toward PC-3, DU-145, H-1299 and HeLa cell lines in a dose-dependent manner and significantly changed the morphologies of the PC-3 cells. The percentage of early stage apoptotic PC-3 cells increased from 11.22 to 22.78% when they were treated with Trp-Pro-Pro concentrations of 5 and 15 mg/ml, respectively, for 24 h. Furthermore, Trp- Pro-Pro could also be used for cancer therapy by scavenging free radicals and the induction of apoptosis of cancer cells.

Specific target protein(s)

N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Blood clams was hydrolyzed by Neutrase, which showed the highest antioxidant and anticancer activities among five enzymes (Papain, Alcalase, Trypsin, Pepsin and Neutrase).

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

Trp-Pro-Pro might serve as a natural antioxidant and anticancer agent for the nutraceutical and pharmaceutical industries.

Database cross-references

DFBP

[D1]	DFBPANOX0593
[D2]	DFBPMUFU0669

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Chi, C.-F., Hu, F.-Y., Wang, B., Li, T., Ding, G.-F. Antioxidant and anticancer peptides from the protein hydrolysate of blood clam (Tegillarca granosa) muscle. Journal of Functional Foods. 2015, 15, 301-13. DOI: 10.1016/j.jff.2015.03.045
Other literature(s)	[1] Chalamaiah M, Yu W, Wu J. Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review.[J]. Food Chemistry, 2018, 245:205-222.
PubDate	2015