The peptide Trp-Pro-Pro showed strong cytotoxicity toward PC-3,
DU-145, H-1299 and HeLa cell lines in a dose-dependent manner and
significantly changed the morphologies of the PC-3 cells. The percentage
of early stage apoptotic PC-3 cells increased from 11.22 to 22.78% when
they were treated with Trp-Pro-Pro concentrations of 5 and 15 mg/ml,
respectively, for 24 h. Furthermore, Trp- Pro-Pro could also be used for cancer therapy by scavenging free radicals and the induction of apoptosis of cancer cells. |