Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANCA0031(Anticancer peptide)

DFBP ID	DFBPANCA0031
Peptide sequence	GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
Type	Native peptide
Peptide/Function name	Anticancer peptide, Dermaseptin B2

Function-activity relationship

Main bioactivity	Anticancer activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Gly-Leu-Trp-Ser-Lys-Ile-Lys-Glu-Val-Gly-Lys-Glu-Ala-Ala-Lys-Ala-Ala-Ala-Lys-Ala-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Val-Ser-Glu-Ala-Val

Single-letter amino acid

GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	3181.68 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

10.27 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

0.1970^c

Hydrophilic residue ratio

66.67%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal, Amphibian
Organism/Source	Hylidae, Giant monkey frog (Phyllomedusa bicolor)
Precursor protein	Skin secretions
Residue position	N.D
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	Link 1: DFBPANCA0374----Sythesis----Sythesis peptide

Biological/Functional activity & target protein

Anticancer activity	Inhibited the proliferation of PC-3 cells.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	Synthesis peptide

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	van Zoggel H, Hamma-Kourbali Y, Galanth C, Ladram A, Nicolas P, Courty J, Amiche M, Delbé J. Antitumor and angiostatic peptides from frog skin secretions. Amino Acids. 2012 Jan;42(1):385-95. PMID: 21132338 DOI: 10.1007/s00726-010-0815-9
Other literature(s)	[1] Wang L, Dong C, Li X, et al. Anticancer potential of bioactive peptides from animal sources (Review).[J]. Oncology Reports, 2017, 38(2).
PubDate	2012