DFBP ID - DFBPANCA0070(Anticancer peptide)

DFBP ID DFBPANCA0070 Peptide sequence GVIDAAKKVVNVLKNLFG Type Native peptide Peptide/Function name Anticancer peptide, Uperin 3.6

Function-activity relationship

Main bioactivity Anticancer activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Gly-Val-Ile-Asp-Ala-Ala-Lys-Lys-Val-Val-Asn-Val-Leu-Lys-Asn-Leu-Phe-Gly Single-letter amino acid GVIDAAKKVVNVLKNLFG Peptide length 18 Peptide mass Experimental mass Theoretical mass N.D 1885.27 Da c Net charge 0.00 c Isoelectric point (pI) 10.32 c IC50 N.D pIC50 N.D GRAVY 0.6833 c Hydrophilic residue ratio 66.67% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Australian Bell Frog Precursor protein Granular dorsal gland Residue position N.D Precursor protein(s) search No matching precursor protein found Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Anticancer activity The peptide showed wide-spectrum antibiotic and anticancer activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools No prediction can be made about the peptide bitterness. prediction SMILES NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

BIOPEP-UWM [D1] 3913, 3918

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Rozek, T., Bowie, J.H., Wallace, J.C., Tyler, M.J. The antibiotic and anticancer active aurein peptides from the Australian Bell FrogsLitoria aurea andLitoria raniformis. Part 2. Sequence determination using electrospray mass spectrometry. Rapid Communications in Mass Spectrometry. 2000, 14, 2002-11. DOI: 10.1002/1097-0231(20001115)14:21<2002::AID-RCM128>3.0.CO;2-3 Other literature(s) N.D PubDate 2000