DFBP ID - DFBPANCA0089(Anticancer peptide)

DFBP ID DFBPANCA0089 Peptide sequence ENLLRFFVAPFPEVFG Type Native peptide Peptide/Function name Anticancer peptide

Function-activity relationship

Main bioactivity Anticancer activity Otheir bioactivity ACE-inhibitory activity [D1], Multifunctional activity [D2]

Calculated physicochemical properties

Three-letter amino acid Glu-Asn-Leu-Leu-Arg-Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val-Phe-Gly Single-letter amino acid ENLLRFFVAPFPEVFG Peptide length 16 Peptide mass Experimental mass Theoretical mass N.D 1882.17 Da c Net charge 0.00 c Isoelectric point (pI) 4.33 c IC50 N.D pIC50 N.D GRAVY 0.6500 c Hydrophilic residue ratio 75% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Bovine Precursor protein Casein protein Residue position N.D Precursor protein(s) search Source.1: DFBPPR7717 ---- Milk proteins ---- Alpha-S1-casein Source.2: DFBPPR8488 ---- Milk proteins ---- Alpha-S1-casein Link-research Inductive analysis Link 1: DFBPANCA0104----Bovine milk----αs1-Casein

Biological/Functional activity & target protein

Anticancer activity The peptide showed anticancer activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPACEI1440 [D2] DFBPMUFU0384

BIOPEP-UWM [D3] 8312

APD [D4] -

BioPepDB [D5] -

MBPDB [D6] -

Reference(s)

Primary literature Juillerat-Jeanneret L, Robert MC, Juillerat MA. Peptides from Lactobacillus hydrolysates of bovine milk caseins inhibit prolyl-peptidases of human colon cells. J Agric Food Chem. 2011 Jan 12;59(1):370-7. PMID: 21126072 DOI: 10.1021/jf102803a Other literature(s) N.D PubDate 2011