DFBP ID - DFBPANCA0094(Anticancer peptide)

DFBP ID DFBPANCA0094 Peptide sequence VENLHLPLPLL Type Native peptide Peptide/Function name Anticancer peptide

Function-activity relationship

Main bioactivity Anticancer activity Otheir bioactivity ACE-inhibitory activity [D1], Multifunctional activity [D2]

Calculated physicochemical properties

Three-letter amino acid Val-Glu-Asn-Leu-His-Leu-Pro-Leu-Pro-Leu-Leu Single-letter amino acid VENLHLPLPLL Peptide length 11 Peptide mass Experimental mass Theoretical mass N.D 1257.52 Da c Net charge 0.00 c Isoelectric point (pI) 5.17 c IC50 N.D pIC50 N.D GRAVY 0.8909 c Hydrophilic residue ratio 72.73% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Bovine Precursor protein Casein protein Residue position N.D Precursor protein(s) search Source.1: DFBPPR7718 ---- Milk proteins ---- Beta-casein Source.2: DFBPPR8489 ---- Milk proteins ---- Beta-casein Link-research Inductive analysis Link 1: DFBPANCA0109----Bovine milk----β-Casein

Biological/Functional activity & target protein

Anticancer activity The peptide showed anticancer activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPACEI1438 [D2] DFBPMUFU0382

BIOPEP-UWM [D3] 8317

APD [D4] -

BioPepDB [D5] -

MBPDB [D6] -

Reference(s)

Primary literature Juillerat-Jeanneret L, Robert MC, Juillerat MA. Peptides from Lactobacillus hydrolysates of bovine milk caseins inhibit prolyl-peptidases of human colon cells. J Agric Food Chem. 2011 Jan 12;59(1):370-7. PMID: 21126072 DOI: 10.1021/jf102803a Other literature(s) N.D PubDate 2011