DFBP ID - DFBPANCA0339(Anticancer peptide)

DFBP ID DFBPANCA0339 Peptide sequence FKRIVQRIKDFLRNLV Type Native peptide Peptide/Function name Anticancer peptide

Function-activity relationship

Main bioactivity Anticancer activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val Single-letter amino acid FKRIVQRIKDFLRNLV Peptide length 16 Peptide mass Experimental mass Theoretical mass N.D 2045.48 Da c Net charge 0.00 c Isoelectric point (pI) 12.23 c IC50 N.D pIC50 N.D GRAVY -0.0750 c Hydrophilic residue ratio 50% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source  Human Precursor protein The peptide LL-37 Residue position Residues 17–32 of LL37 Precursor protein(s) search No matching precursor protein found Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Anticancer activity The anticancer peptide FK-16 induces AIF/EndoG-dependent apoptosis and autophagic cell death via the common p53-Bax/Bcl-2 cascade in colon cancer cells. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N.D

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture N.D

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

BIOPEP-UWM [D1] -

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Quemé-Peña M, Juhász T, Kohut G, Ricci M, Singh P, Szigyártó IC, Papp ZI, Fülöp L, Beke-Somfai T. Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage. Int J Mol Sci. 2021 Aug 10;22(16):8613. PMID: PMC8395313 DOI: 10.3390/ijms22168613 Other literature(s) [1] Ren SX, Shen J, Cheng ASL, Lu L, Chan RLY, Li ZJ, et al. (2013) FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells. PLoS ONE 8(5): e63641. https://doi.org/10.1371/journal.pone.0063641 PubDate 2021