DFBP ID - DFBPANCA0341(Anticancer peptide)

DFBP ID DFBPANCA0341 Peptide sequence VKLRSLLCS Type Native peptide Peptide/Function name Anticancer peptide, VS-9

Function-activity relationship

Main bioactivity Anticancer activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Val-Lys-Leu-Arg-Ser-Leu-Leu-Cys-Ser Single-letter amino acid VKLRSLLCS Peptide length 9 Peptide mass Experimental mass Theoretical mass 1018.28 Da 1018.27 Da c Net charge 0.00 c Isoelectric point (pI) 10.05 c IC50 N.D pIC50 N.D GRAVY 0.9000 c Hydrophilic residue ratio 44.44% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Plant Organism/Source Garlic Precursor protein Enzymatic protein hydrolysate of garlic Residue position N.D Precursor protein(s) search No matching precursor protein found Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Anticancer activity VS-9 could induce apoptosis on leukemic cells via intrinsic and extrinsic apoptosis pathways. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N.D

Preparation method

Mode of preparation Enzymatic hydrolysis Enzyme(s)/starter culture The peptide VS-9 was enzymatically hydrolyzed by pepsin through added to the extracted garlic proteins.

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

BIOPEP-UWM [D1] -

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Rasaratnam K, Nantasenamat C, Phaonakrop N, Roytrakul S, Tanyong D. A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with Bcl-2 family proteins. Chem Biol Drug Des. 2021 May;97(5):1017-1028. PMID: 33595876 DOI: 10.1111/cbdd.13831 Other literature(s) N.D PubDate 2021