Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANHY0005(Antihypertensive peptide)

DFBP ID	DFBPANHY0005
Peptide sequence	LPLP
Type	Native peptide
Peptide/Function name	Antihypertensive peptide

Function-activity relationship

Main bioactivity	Antihypertensive activity
Otheir bioactivity	ACE-inhibitory activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Leu-Pro-Leu-Pro

Single-letter amino acid

LPLP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	438.55 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.97 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

1.1000^c

Hydrophilic residue ratio

100%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Milk protein
Precursor protein	β-Casein
Residue position	f(135-138)
Precursor protein(s) search	Source.1: DFBPPR0810 ---- Plant proteins ---- APETALA2-like protein 1 Source.2: DFBPPR0834 ---- Plant proteins ---- Protein ABERRANT PANICLE ORGANIZATION 1 Source.3: DFBPPR0918 ---- Plant proteins ---- bZIP transcription factor ABI5 homolog Source.4: DFBPPR0951 ---- Plant proteins ---- Calpain-type cysteine protease ADL1 Source.5: DFBPPR0990 ---- Plant proteins ---- LysM domain receptor-like kinase 10 Source.6: DFBPPR0992 ---- Plant proteins ---- Zeaxanthin epoxidase, chloroplastic Source.7: DFBPPR1125 ---- Plant proteins ---- Protein FLOURY ENDOSPERM 6, chloroplastic Source.8: DFBPPR1147 ---- Plant proteins ---- ABC transporter C family member 13 Source.9: DFBPPR1260 ---- Plant proteins ---- Peptide deformylase 1A, chloroplastic Source.10: DFBPPR1262 ---- Plant proteins ---- Abscisic acid 8'-hydroxylase 1 Source.11: DFBPPR1300 ---- Plant proteins ---- Protein G1 Source.12: DFBPPR1314 ---- Plant proteins ---- Ferredoxin-dependent glutamate synthase, chloroplastic Source.13: DFBPPR1336 ---- Plant proteins ---- Protein argonaute 7 Source.14: DFBPPR1391 ---- Plant proteins ---- DNA (cytosine-5)-methyltransferase CMT3 Source.15: DFBPPR1484 ---- Plant proteins ---- Allene oxide synthase 2 Source.16: DFBPPR1578 ---- Plant proteins ---- Cyclin-B2-2 Source.17: DFBPPR1612 ---- Plant proteins ---- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 Source.18: DFBPPR1624 ---- Plant proteins ---- ATP-dependent zinc metalloprotease FTSH 9, chloroplastic/mitochondrial Source.19: DFBPPR1638 ---- Plant proteins ---- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 Source.20: DFBPPR1653 ---- Plant proteins ---- Protein CHLOROPLAST ENHANCING STRESS TOLERANCE, chloroplastic Source.21: DFBPPR1776 ---- Plant proteins ---- Lon protease homolog, mitochondrial Source.22: DFBPPR1798 ---- Plant proteins ---- UMP-CMP kinase 2 Source.23: DFBPPR1805 ---- Plant proteins ---- Probable polyribonucleotide nucleotidyltransferase 1, chloroplastic Source.24: DFBPPR1847 ---- Plant proteins ---- Amidase 1 Source.25: DFBPPR1859 ---- Plant proteins ---- Heat stress transcription factor B-2b Source.26: DFBPPR1866 ---- Plant proteins ---- Probable DNA gyrase subunit A, chloroplastic/mitochondrial Source.27: DFBPPR1880 ---- Plant proteins ---- Putative laccase-11 Source.28: DFBPPR1907 ---- Plant proteins ---- Very-long-chain aldehyde decarbonylase GL1-8 Source.29: DFBPPR1922 ---- Plant proteins ---- Cyclin-dependent kinase G-2 Source.30: DFBPPR1927 ---- Plant proteins ---- Cyclin-dependent kinase G-1 Source.31: DFBPPR1950 ---- Plant proteins ---- Flavonoid 3'-monooxygenase CYP75B4 Source.32: DFBPPR1959 ---- Plant proteins ---- DNA gyrase subunit B, chloroplastic/mitochondrial Source.33: DFBPPR2037 ---- Plant proteins ---- Laccase-10 Source.34: DFBPPR2049 ---- Plant proteins ---- Auxin response factor 19 Source.35: DFBPPR2051 ---- Plant proteins ---- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase Source.36: DFBPPR2053 ---- Plant proteins ---- Putative laccase-5 Source.37: DFBPPR2058 ---- Plant proteins ---- Cytokinin dehydrogenase 9 Source.38: DFBPPR2109 ---- Plant proteins ---- DNA (cytosine-5)-methyltransferase CMT1 Source.39: DFBPPR2121 ---- Plant proteins ---- Cellulose synthase-like protein D5 Source.40: DFBPPR2177 ---- Plant proteins ---- Very-long-chain aldehyde decarbonylase GL1-11 Source.41: DFBPPR2188 ---- Plant proteins ---- Probable 2-oxoglutarate-dependent dioxygenase SLC2 Source.42: DFBPPR2303 ---- Plant proteins ---- Very-long-chain aldehyde decarbonylase GL1-10 Source.43: DFBPPR2321 ---- Plant proteins ---- Aspartate carbamoyltransferase, chloroplastic Source.44: DFBPPR2393 ---- Plant proteins ---- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic Source.45: DFBPPR2404 ---- Plant proteins ---- Homeobox-leucine zipper protein TF1 Source.46: DFBPPR2419 ---- Plant proteins ---- U-box domain-containing protein 73 Source.47: DFBPPR2420 ---- Plant proteins ---- Probable transcription factor GLK1 Source.48: DFBPPR2434 ---- Plant proteins ---- Non-specific lipid transfer protein-like 1 Source.49: DFBPPR2545 ---- Plant proteins ---- Serine/threonine-protein kinase Nek1 Source.50: DFBPPR2583 ---- Plant proteins ---- Thioredoxin-like 2, chloroplastic Source.51: DFBPPR2646 ---- Plant proteins ---- CBL-interacting protein kinase 25 Source.52: DFBPPR2669 ---- Plant proteins ---- Arginine decarboxylase 1 Source.53: DFBPPR2789 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.54: DFBPPR2945 ---- Plant proteins ---- Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic Source.55: DFBPPR3044 ---- Plant proteins ---- Thioredoxin-like 4, chloroplastic Source.56: DFBPPR3131 ---- Plant proteins ---- Ribonuclease III domain-containing protein RNC1, chloroplastic Source.57: DFBPPR3180 ---- Plant proteins ---- Probable glucuronosyltransferase Os01g0926700 Source.58: DFBPPR3187 ---- Plant proteins ---- Probable glucuronosyltransferase Os10g0205300 Source.59: DFBPPR3217 ---- Plant proteins ---- Probable glucuronosyltransferase Os02g0520750 Source.60: DFBPPR3223 ---- Plant proteins ---- Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic Source.61: DFBPPR3229 ---- Plant proteins ---- Transcription factor TGAL7 Source.62: DFBPPR3230 ---- Plant proteins ---- Probable protein phosphatase 2C 37 Source.63: DFBPPR3371 ---- Plant proteins ---- Kinesin-like protein KIN-14R Source.64: DFBPPR3396 ---- Plant proteins ---- Probable transcription factor GLK2 Source.65: DFBPPR3438 ---- Plant proteins ---- Protein ROLLING AND ERECT LEAF 2 Source.66: DFBPPR3473 ---- Plant proteins ---- Probable glucuronosyltransferase Os04g0398600 Source.67: DFBPPR3609 ---- Plant proteins ---- Thioredoxin-like 1-1, chloroplastic Source.68: DFBPPR3612 ---- Plant proteins ---- Kinesin-like protein KIN-6 Source.69: DFBPPR3632 ---- Plant proteins ---- Probable linoleate 9S-lipoxygenase 4 Source.70: DFBPPR3673 ---- Plant proteins ---- Zinc-finger homeodomain protein 3 Source.71: DFBPPR3786 ---- Plant proteins ---- Kinesin-like protein KIN-14D Source.72: DFBPPR3803 ---- Plant proteins ---- Probable trehalase Source.73: DFBPPR3951 ---- Plant proteins ---- Xyloglucan galactosyltransferase KATAMARI1 homolog Source.74: DFBPPR3985 ---- Plant proteins ---- 4-coumarate--CoA ligase-like 2 Source.75: DFBPPR4066 ---- Plant proteins ---- Pescadillo homolog Source.76: DFBPPR4080 ---- Plant proteins ---- Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic Source.77: DFBPPR4096 ---- Plant proteins ---- Cytochrome c biogenesis protein CCS1, chloroplastic Source.78: DFBPPR4177 ---- Plant proteins ---- Formin-like protein 16 Source.79: DFBPPR4239 ---- Plant proteins ---- Probable metal-nicotianamine transporter YSL10 Source.80: DFBPPR4287 ---- Plant proteins ---- Dehydration-responsive element-binding protein 2D Source.81: DFBPPR4355 ---- Plant proteins ---- Putative cyclin-F1-3 Source.82: DFBPPR4362 ---- Plant proteins ---- Putative cyclin-F1-1 Source.83: DFBPPR4395 ---- Plant proteins ---- Putative cyclin-F1-4 Source.84: DFBPPR4472 ---- Plant proteins ---- BURP domain-containing protein 15 Source.85: DFBPPR4553 ---- Plant proteins ---- Phospholipase A1-II 7 Source.86: DFBPPR4674 ---- Plant proteins ---- Double-stranded RNA-binding protein 1 Source.87: DFBPPR4676 ---- Plant proteins ---- PP2A regulatory subunit TAP46 Source.88: DFBPPR4706 ---- Plant proteins ---- Tubby-like protein 4 Source.89: DFBPPR4736 ---- Plant proteins ---- B3 domain-containing protein Os04g0581400 Source.90: DFBPPR4791 ---- Plant proteins ---- B3 domain-containing protein Os02g0683500 Source.91: DFBPPR4827 ---- Plant proteins ---- BURP domain-containing protein 1 Source.92: DFBPPR5026 ---- Plant proteins ---- Phosphatidylinositol 3-kinase, root isoform Source.93: DFBPPR5027 ---- Plant proteins ---- Phosphatidylinositol 3-kinase, nodule isoform Source.94: DFBPPR5028 ---- Plant proteins ---- Glutathione reductase, chloroplastic Source.95: DFBPPR5068 ---- Plant proteins ---- Ferritin-3, chloroplastic Source.96: DFBPPR5217 ---- Plant proteins ---- Soyasaponin III rhamnosyltransferase Source.97: DFBPPR5387 ---- Plant proteins ---- Calpain-type cysteine protease DEK1 Source.98: DFBPPR5454 ---- Plant proteins ---- Ferredoxin-dependent glutamate synthase, chloroplastic Source.99: DFBPPR5462 ---- Plant proteins ---- Cysteine--tRNA ligase CPS1, chloroplastic/mitochondrial Source.100: DFBPPR5522 ---- Plant proteins ---- ABC transporter C family MRP4 Source.101: DFBPPR5525 ---- Plant proteins ---- Lon protease homolog, mitochondrial Source.102: DFBPPR5628 ---- Plant proteins ---- 3-hydroxy-3-methylglutaryl-coenzyme A reductase Source.103: DFBPPR5631 ---- Plant proteins ---- DNA (cytosine-5)-methyltransferase 1 Source.104: DFBPPR5632 ---- Plant proteins ---- CRS2-associated factor 2, chloroplastic Source.105: DFBPPR5709 ---- Plant proteins ---- indolin-2-one monooxygenase Source.106: DFBPPR5759 ---- Plant proteins ---- Protein TAB2 homolog, chloroplastic Source.107: DFBPPR5813 ---- Plant proteins ---- DNA (cytosine-5)-methyltransferase 2 Source.108: DFBPPR5814 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.109: DFBPPR5832 ---- Plant proteins ---- DNA (cytosine-5)-methyltransferase 3 Source.110: DFBPPR5869 ---- Plant proteins ---- Anthocyanin regulatory Lc protein Source.111: DFBPPR5910 ---- Plant proteins ---- Anthocyanin regulatory R-S protein Source.112: DFBPPR5962 ---- Plant proteins ---- Protein RIK Source.113: DFBPPR5992 ---- Plant proteins ---- Aquaporin NIP3-1 Source.114: DFBPPR6466 ---- Plant proteins ---- Arginine decarboxylase Source.115: DFBPPR6831 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.116: DFBPPR7187 ---- Plant proteins ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.117: DFBPPR7202 ---- Plant proteins ---- UTP--glucose-1-phosphate uridylyltransferase Source.118: DFBPPR7605 ---- Milk proteins ---- Beta-casein Source.119: DFBPPR7633 ---- Milk proteins ---- Chordin-like protein 2 Source.120: DFBPPR7654 ---- Milk proteins ---- Kallikrein-12 Source.121: DFBPPR7665 ---- Milk proteins ---- Beta-casein Source.122: DFBPPR7692 ---- Milk proteins ---- Beta-casein Source.123: DFBPPR7700 ---- Milk proteins ---- Beta-casein Source.124: DFBPPR7718 ---- Milk proteins ---- Beta-casein Source.125: DFBPPR8392 ---- Plant proteins ---- 11-beta-hydroxysteroid dehydrogenase B Source.126: DFBPPR8421 ---- Plant proteins ---- 11-beta-hydroxysteroid dehydrogenase B Source.127: DFBPPR8489 ---- Milk proteins ---- Beta-casein Source.128: DFBPPR15952 ---- Animal proteins ---- Galectin-3 Source.129: DFBPPR16023 ---- Animal proteins ---- Platelet-derived growth factor receptor beta Source.130: DFBPPR16105 ---- Animal proteins ---- Collagen alpha-1(XVII) chain Source.131: DFBPPR16134 ---- Animal proteins ---- Growth hormone receptor Source.132: DFBPPR16147 ---- Animal proteins ---- Telomerase reverse transcriptase Source.133: DFBPPR16185 ---- Animal proteins ---- Cytokine receptor common subunit gamma Source.134: DFBPPR16229 ---- Animal proteins ---- 5-hydroxytryptamine receptor 1A Source.135: DFBPPR16243 ---- Animal proteins ---- Retinoic acid receptor RXR-beta Source.136: DFBPPR16270 ---- Animal proteins ---- AP-4 complex subunit mu-1 Source.137: DFBPPR16321 ---- Animal proteins ---- Aggrecan core protein Source.138: DFBPPR16474 ---- Animal proteins ---- Pinin Source.139: DFBPPR16506 ---- Animal proteins ---- Pepsin B Source.140: DFBPPR16561 ---- Animal proteins ---- UDP-glucuronosyltransferase 2B31 Source.141: DFBPPR16621 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.142: DFBPPR16635 ---- Animal proteins ---- Corticoliberin Source.143: DFBPPR16641 ---- Animal proteins ---- Alpha-(1,3)-fucosyltransferase 10 Source.144: DFBPPR16647 ---- Animal proteins ---- Tudor domain-containing protein 7 Source.145: DFBPPR16668 ---- Animal proteins ---- Zinc finger and BTB domain-containing protein 22 Source.146: DFBPPR16705 ---- Animal proteins ---- G2/mitotic-specific cyclin-B3 Source.147: DFBPPR16806 ---- Animal proteins ---- Cytosol aminopeptidase Source.148: DFBPPR16829 ---- Animal proteins ---- Fibroblast growth factor 1 Source.149: DFBPPR16850 ---- Animal proteins ---- Growth hormone receptor Source.150: DFBPPR16925 ---- Animal proteins ---- Supervillin Source.151: DFBPPR16934 ---- Animal proteins ---- Coagulation factor V Source.152: DFBPPR16941 ---- Animal proteins ---- Sodium/potassium/calcium exchanger 1 Source.153: DFBPPR16987 ---- Animal proteins ---- Aggrecan core protein Source.154: DFBPPR17000 ---- Animal proteins ---- Vimentin Source.155: DFBPPR17071 ---- Animal proteins ---- Insulin-like growth factor 1 receptor Source.156: DFBPPR17135 ---- Animal proteins ---- Histidine-rich glycoprotein Source.157: DFBPPR17170 ---- Animal proteins ---- A disintegrin and metalloproteinase with thrombospondin motifs 2 Source.158: DFBPPR17330 ---- Animal proteins ---- Unconventional myosin-X Source.159: DFBPPR17476 ---- Animal proteins ---- Heterogeneous nuclear ribonucleoprotein K Source.160: DFBPPR17616 ---- Animal proteins ---- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 Source.161: DFBPPR17634 ---- Animal proteins ---- Hypoxia-inducible factor 1-alpha Source.162: DFBPPR17644 ---- Animal proteins ---- CCAAT/enhancer-binding protein beta Source.163: DFBPPR17683 ---- Animal proteins ---- Cyanocobalamin reductase / alkylcobalamin dealkylase Source.164: DFBPPR17754 ---- Animal proteins ---- Amelogenin, X isoform Source.165: DFBPPR17863 ---- Animal proteins ---- Lanosterol 14-alpha demethylase Source.166: DFBPPR17870 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 4 Source.167: DFBPPR17961 ---- Animal proteins ---- Cyclin-dependent kinase 12 Source.168: DFBPPR17977 ---- Animal proteins ---- Collagenase 3 Source.169: DFBPPR17980 ---- Animal proteins ---- Serine/threonine-protein kinase haspin Source.170: DFBPPR18129 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 15 Source.171: DFBPPR18172 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.172: DFBPPR18173 ---- Animal proteins ---- Cytokine receptor common subunit gamma Source.173: DFBPPR18360 ---- Animal proteins ---- Desmocollin-3 Source.174: DFBPPR18536 ---- Animal proteins ---- Plastin-1 Source.175: DFBPPR18563 ---- Animal proteins ---- Collectin-43 Source.176: DFBPPR18567 ---- Animal proteins ---- Dynein heavy chain 12, axonemal Source.177: DFBPPR18597 ---- Animal proteins ---- Telethonin Source.178: DFBPPR18695 ---- Animal proteins ---- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Source.179: DFBPPR18702 ---- Animal proteins ---- E3 ubiquitin-protein ligase E3D Source.180: DFBPPR18708 ---- Animal proteins ---- ATPase family AAA domain-containing protein 3 Source.181: DFBPPR18794 ---- Animal proteins ---- LIM domain-containing protein ajuba Source.182: DFBPPR18813 ---- Animal proteins ---- Acyl-CoA synthetase short-chain family member 3, mitochondrial Source.183: DFBPPR18822 ---- Animal proteins ---- Sterol regulatory element-binding protein cleavage-activating protein Source.184: DFBPPR18888 ---- Animal proteins ---- Glutathione hydrolase 6 Source.185: DFBPPR19073 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 21 Source.186: DFBPPR19075 ---- Animal proteins ---- Ubiquitin-conjugating enzyme E2 J2 Source.187: DFBPPR19085 ---- Animal proteins ---- AP-4 complex subunit mu-1 Source.188: DFBPPR19104 ---- Animal proteins ---- Inter-alpha-trypsin inhibitor heavy chain H4 Source.189: DFBPPR19251 ---- Animal proteins ---- Leucine-rich repeat-containing G-protein coupled receptor 5 Source.190: DFBPPR19334 ---- Animal proteins ---- Lysosomal acid phosphatase Source.191: DFBPPR19367 ---- Animal proteins ---- Atypical chemokine receptor 1 Source.192: DFBPPR19379 ---- Animal proteins ---- Advanced glycosylation end product-specific receptor Source.193: DFBPPR19617 ---- Animal proteins ---- Suppressor of cytokine signaling 2 Source.194: DFBPPR19664 ---- Animal proteins ---- Protein OS-9 Source.195: DFBPPR19770 ---- Animal proteins ---- Heat shock 70 kDa protein 13 Source.196: DFBPPR19797 ---- Animal proteins ---- Inactive serine/threonine-protein kinase VRK3 Source.197: DFBPPR19814 ---- Animal proteins ---- Protein delta homolog 2 Source.198: DFBPPR19857 ---- Animal proteins ---- DnaJ homolog subfamily B member 1 Source.199: DFBPPR19861 ---- Animal proteins ---- Phospholipid phosphatase-related protein type 2 Source.200: DFBPPR20262 ---- Animal proteins ---- DNA-directed RNA polymerase I subunit RPA12 Source.201: DFBPPR20275 ---- Animal proteins ---- Malonate--CoA ligase ACSF3, mitochondrial Source.202: DFBPPR20281 ---- Animal proteins ---- Splicing factor 3A subunit 2 Source.203: DFBPPR20394 ---- Animal proteins ---- Actin filament-associated protein 1-like 2 Source.204: DFBPPR20434 ---- Animal proteins ---- SPRY domain-containing SOCS box protein 1 Source.205: DFBPPR20451 ---- Animal proteins ---- Alpha-(1,3)-fucosyltransferase 10 Source.206: DFBPPR20505 ---- Animal proteins ---- T-box transcription factor TBX6 Source.207: DFBPPR20517 ---- Animal proteins ---- RNA-binding protein 42 Source.208: DFBPPR20702 ---- Animal proteins ---- 5-azacytidine-induced protein 2 Source.209: DFBPPR20835 ---- Animal proteins ---- TBC1 domain family member 24 Source.210: DFBPPR20909 ---- Animal proteins ---- Macrophage immunometabolism regulator Source.211: DFBPPR21041 ---- Animal proteins ---- Cytokine-inducible SH2-containing protein Source.212: DFBPPR21057 ---- Animal proteins ---- KICSTOR complex protein ITFG2 Source.213: DFBPPR21073 ---- Animal proteins ---- 39S ribosomal protein L17, mitochondrial Source.214: DFBPPR21116 ---- Animal proteins ---- Suppressor of cytokine signaling 5 Source.215: DFBPPR21122 ---- Animal proteins ---- Derlin-3 Source.216: DFBPPR21257 ---- Animal proteins ---- Mesoderm induction early response protein 2 Source.217: DFBPPR21311 ---- Animal proteins ---- WD repeat-containing protein 18 Source.218: DFBPPR21345 ---- Animal proteins ---- XIAP-associated factor 1 Source.219: DFBPPR21429 ---- Animal proteins ---- Histone PARylation factor 1 Source.220: DFBPPR21432 ---- Animal proteins ---- Amelogenin, Y isoform Source.221: DFBPPR21483 ---- Animal proteins ---- F-box/LRR-repeat protein 8 Source.222: DFBPPR21552 ---- Animal proteins ---- SPRY domain-containing SOCS box protein 3 Source.223: DFBPPR21587 ---- Animal proteins ---- Abnormal spindle-like microcephaly-associated protein homolog Source.224: DFBPPR21681 ---- Animal proteins ---- Protein FAM110A Source.225: DFBPPR21721 ---- Animal proteins ---- Doublesex- and mab-3-related transcription factor C2 Source.226: DFBPPR21784 ---- Animal proteins ---- O(6)-methylguanine-induced apoptosis 2 Source.227: DFBPPR21794 ---- Animal proteins ---- Ankyrin repeat and SOCS box protein 8 Source.228: DFBPPR21836 ---- Animal proteins ---- Potassium channel regulatory protein Source.229: DFBPPR21844 ---- Animal proteins ---- Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 Source.230: DFBPPR21857 ---- Animal proteins ---- Ankyrin repeat and SOCS box protein 2 Source.231: DFBPPR21863 ---- Animal proteins ---- Ankyrin repeat and SOCS box protein 3 Source.232: DFBPPR21900 ---- Animal proteins ---- Cyclin-D1-binding protein 1 Source.233: DFBPPR21921 ---- Animal proteins ---- AP-5 complex subunit beta-1 Source.234: DFBPPR21995 ---- Animal proteins ---- Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Source.235: DFBPPR22080 ---- Animal proteins ---- Integrator complex subunit 9 Source.236: DFBPPR22100 ---- Animal proteins ---- Centromere protein M Source.237: DFBPPR22147 ---- Animal proteins ---- Immunoglobulin superfamily containing leucine-rich repeat protein Source.238: DFBPPR22156 ---- Animal proteins ---- Cell division cycle protein 123 homolog Source.239: DFBPPR22322 ---- Animal proteins ---- Testis-specific protein 10-interacting protein Source.240: DFBPPR22330 ---- Animal proteins ---- Rho guanine nucleotide exchange factor 39 Source.241: DFBPPR22331 ---- Animal proteins ---- Zinc finger SWIM domain-containing protein 8 Source.242: DFBPPR22385 ---- Animal proteins ---- Coiled-coil domain-containing protein 102A Source.243: DFBPPR22432 ---- Animal proteins ---- Protein FAM124B Source.244: DFBPPR22454 ---- Animal proteins ---- R3H domain-containing protein 4 Source.245: DFBPPR22493 ---- Animal proteins ---- PC-esterase domain-containing protein 1B Source.246: DFBPPR22494 ---- Animal proteins ---- Protein FAM53C Source.247: DFBPPR22578 ---- Animal proteins ---- Protein FAM71F1 Source.248: DFBPPR22611 ---- Animal proteins ---- Coiled-coil domain-containing protein 105 Source.249: DFBPPR22762 ---- Animal proteins ---- Uncharacterized protein C6orf136 homolog Source.250: DFBPPR8606 ---- Animal proteins ---- Stimulator of interferon genes protein Source.251: DFBPPR8659 ---- Animal proteins ---- Fibroblast growth factor 1 Source.252: DFBPPR8672 ---- Animal proteins ---- Fatty-acid amide hydrolase 1 Source.253: DFBPPR8716 ---- Animal proteins ---- Thyroid peroxidase Source.254: DFBPPR8737 ---- Animal proteins ---- Growth hormone receptor Source.255: DFBPPR8743 ---- Animal proteins ---- Phosphatidylcholine-sterol acyltransferase Source.256: DFBPPR8776 ---- Animal proteins ---- Serine/threonine-protein kinase WNK1 Source.257: DFBPPR8820 ---- Animal proteins ---- Ectonucleoside triphosphate diphosphohydrolase 1 Source.258: DFBPPR8851 ---- Animal proteins ---- Vimentin Source.259: DFBPPR8852 ---- Animal proteins ---- Vimentin Source.260: DFBPPR8854 ---- Animal proteins ---- Vimentin Source.261: DFBPPR8871 ---- Animal proteins ---- Lanosterol 14-alpha demethylase Source.262: DFBPPR8872 ---- Animal proteins ---- Lanosterol 14-alpha demethylase Source.263: DFBPPR8978 ---- Animal proteins ---- Inter-alpha-trypsin inhibitor heavy chain H4 Source.264: DFBPPR9008 ---- Animal proteins ---- Sterol regulatory element-binding protein cleavage-activating protein Source.265: DFBPPR9043 ---- Animal proteins ---- Cytosol aminopeptidase Source.266: DFBPPR9102 ---- Animal proteins ---- Nuclear factor of activated T-cells, cytoplasmic 1 Source.267: DFBPPR9141 ---- Animal proteins ---- Suppressor of cytokine signaling 2 Source.268: DFBPPR9152 ---- Animal proteins ---- Insulin-like growth factor 1 receptor Source.269: DFBPPR9169 ---- Animal proteins ---- Aggrecan core protein Source.270: DFBPPR9276 ---- Animal proteins ---- Type I iodothyronine deiodinase Source.271: DFBPPR9423 ---- Animal proteins ---- E3 ubiquitin-protein ligase TRIM50 Source.272: DFBPPR9656 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.273: DFBPPR9678 ---- Animal proteins ---- Neuropeptide W Source.274: DFBPPR9738 ---- Animal proteins ---- Protein delta homolog 2 Source.275: DFBPPR9776 ---- Animal proteins ---- Zinc finger protein PLAGL1 Source.276: DFBPPR9781 ---- Animal proteins ---- Tripartite motif-containing protein 15 Source.277: DFBPPR9957 ---- Animal proteins ---- Ovoinhibitor Source.278: DFBPPR9986 ---- Animal proteins ---- Aggrecan core protein Source.279: DFBPPR10080 ---- Animal proteins ---- High affinity nerve growth factor receptor Source.280: DFBPPR10175 ---- Animal proteins ---- Platelet-derived growth factor receptor alpha Source.281: DFBPPR10229 ---- Animal proteins ---- Phosphoinositide 3-kinase adapter protein 1 Source.282: DFBPPR10230 ---- Animal proteins ---- B-cell linker protein Source.283: DFBPPR10264 ---- Animal proteins ---- Fibroblast growth factor 1 Source.284: DFBPPR10387 ---- Animal proteins ---- DNA-directed primase/polymerase protein Source.285: DFBPPR10388 ---- Animal proteins ---- Ephrin type-B receptor 5 Source.286: DFBPPR10422 ---- Animal proteins ---- Collagen alpha-1(XII) chain Source.287: DFBPPR10447 ---- Animal proteins ---- Plastin-1 Source.288: DFBPPR10457 ---- Animal proteins ---- Transcriptional enhancer factor TEF-3 Source.289: DFBPPR10459 ---- Animal proteins ---- Reelin Source.290: DFBPPR10638 ---- Animal proteins ---- Cellular tumor antigen p53 Source.291: DFBPPR10643 ---- Animal proteins ---- Sclerostin domain-containing protein 1 Source.292: DFBPPR10780 ---- Animal proteins ---- Caspase-2 Source.293: DFBPPR10794 ---- Animal proteins ---- Zyxin Source.294: DFBPPR10809 ---- Animal proteins ---- Lysine-specific demethylase 3A Source.295: DFBPPR10845 ---- Animal proteins ---- Cytochrome P450 26A1 Source.296: DFBPPR10846 ---- Animal proteins ---- Gap junction alpha-3 protein Source.297: DFBPPR10906 ---- Animal proteins ---- E3 ubiquitin-protein ligase RNF152 Source.298: DFBPPR10912 ---- Animal proteins ---- Neurexin-3-beta Source.299: DFBPPR10947 ---- Animal proteins ---- Cytosolic carboxypeptidase 1 Source.300: DFBPPR11039 ---- Animal proteins ---- Neurexin-3 Source.301: DFBPPR11074 ---- Animal proteins ---- Hypoxia-inducible factor 1-alpha Source.302: DFBPPR11108 ---- Animal proteins ---- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Source.303: DFBPPR11226 ---- Animal proteins ---- Heterogeneous nuclear ribonucleoprotein K Source.304: DFBPPR11235 ---- Animal proteins ---- G1/S-specific cyclin-D2 Source.305: DFBPPR11243 ---- Animal proteins ---- Epiphycan Source.306: DFBPPR11363 ---- Animal proteins ---- Forkhead box protein D3 Source.307: DFBPPR11409 ---- Animal proteins ---- Transcriptional repressor CTCF Source.308: DFBPPR11571 ---- Animal proteins ---- Alpha-(1,3)-fucosyltransferase 10 Source.309: DFBPPR11645 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 1 Source.310: DFBPPR11649 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.311: DFBPPR11739 ---- Animal proteins ---- Centrosomal protein CCDC61 Source.312: DFBPPR11769 ---- Animal proteins ---- Cytokine-inducible SH2-containing protein Source.313: DFBPPR11807 ---- Animal proteins ---- Activating transcription factor 7-interacting protein 1 Source.314: DFBPPR11838 ---- Animal proteins ---- Enhancer of mRNA-decapping protein 3 Source.315: DFBPPR11889 ---- Animal proteins ---- Olfactory receptor-like protein COR8 Source.316: DFBPPR11920 ---- Animal proteins ---- Transcription initiation factor TFIID subunit 2 Source.317: DFBPPR11958 ---- Animal proteins ---- Homeobox protein engrailed-1 Source.318: DFBPPR12004 ---- Animal proteins ---- Fibronectin type-III domain-containing protein 3a Source.319: DFBPPR12041 ---- Animal proteins ---- Paladin Source.320: DFBPPR12043 ---- Animal proteins ---- Biogenesis of lysosome-related organelles complex 1 subunit 5 Source.321: DFBPPR12063 ---- Animal proteins ---- Centromere protein M Source.322: DFBPPR12064 ---- Animal proteins ---- Integrator complex subunit 9 Source.323: DFBPPR12066 ---- Animal proteins ---- Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 Source.324: DFBPPR12075 ---- Animal proteins ---- Transmembrane protein 70, mitochondrial Source.325: DFBPPR12207 ---- Animal proteins ---- WD repeat, SAM and U-box domain-containing protein 1 Source.326: DFBPPR12303 ---- Animal proteins ---- Histidine-rich glycoprotein Source.327: DFBPPR12393 ---- Animal proteins ---- Growth hormone receptor Source.328: DFBPPR12394 ---- Animal proteins ---- Plasma membrane calcium-transporting ATPase 1 Source.329: DFBPPR12485 ---- Animal proteins ---- Potassium-transporting ATPase alpha chain 2 Source.330: DFBPPR12512 ---- Animal proteins ---- Carbonic anhydrase 4 Source.331: DFBPPR12545 ---- Animal proteins ---- Galectin-3 Source.332: DFBPPR12577 ---- Animal proteins ---- Heterogeneous nuclear ribonucleoprotein K Source.333: DFBPPR12944 ---- Animal proteins ---- Multidrug and toxin extrusion protein 1 Source.334: DFBPPR13016 ---- Animal proteins ---- Bactericidal permeability-increasing protein Source.335: DFBPPR13022 ---- Animal proteins ---- Solute carrier family 13 member 2 Source.336: DFBPPR13028 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.337: DFBPPR13077 ---- Animal proteins ---- Collagen alpha-1(XII) chain Source.338: DFBPPR13078 ---- Animal proteins ---- Amelogenin-like protein Source.339: DFBPPR13225 ---- Animal proteins ---- 5-hydroxytryptamine receptor 1A Source.340: DFBPPR13292 ---- Animal proteins ---- Inhibin alpha chain Source.341: DFBPPR13387 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.342: DFBPPR13586 ---- Animal proteins ---- Fibroblast growth factor 1 Source.343: DFBPPR13632 ---- Animal proteins ---- Growth hormone receptor Source.344: DFBPPR13794 ---- Animal proteins ---- Inhibin alpha chain Source.345: DFBPPR13815 ---- Animal proteins ---- Mast cell protease 2 Source.346: DFBPPR13870 ---- Animal proteins ---- Cathelicidin-3 Source.347: DFBPPR13901 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.348: DFBPPR14014 ---- Animal proteins ---- Somatotropin Source.349: DFBPPR14041 ---- Animal proteins ---- NADH-ubiquinone oxidoreductase chain 3 Source.350: DFBPPR14135 ---- Marine protein ---- CDGSH iron-sulfur domain-containing protein 2A Source.351: DFBPPR14158 ---- Marine protein ---- NADH-ubiquinone oxidoreductase chain 3 Source.352: DFBPPR14252 ---- Marine protein ---- NADH-ubiquinone oxidoreductase chain 3 Source.353: DFBPPR14492 ---- Marine protein ---- Uncharacterized AAA domain-containing protein ycf46 Source.354: DFBPPR14644 ---- Marine protein ---- CDGSH iron-sulfur domain-containing protein 2A Source.355: DFBPPR14652 ---- Marine protein ---- Hypoxia-inducible factor 1-alpha Source.356: DFBPPR14672 ---- Marine protein ---- NADH-ubiquinone oxidoreductase chain 3 Source.357: DFBPPR14754 ---- Marine protein ---- Clotting factor C Source.358: DFBPPR14945 ---- Microorganism protein ---- Decapping nuclease RAI1 Source.359: DFBPPR14962 ---- Microorganism protein ---- Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 Source.360: DFBPPR15017 ---- Microorganism protein ---- Serine/threonine-protein kinase TEL1 Source.361: DFBPPR15183 ---- Microorganism protein ---- Homoaconitase, mitochondrial Source.362: DFBPPR15215 ---- Microorganism protein ---- Protein transport protein SEC24 Source.363: DFBPPR15314 ---- Microorganism protein ---- Probable metalloprotease ARX1 Source.364: DFBPPR15429 ---- Microorganism protein ---- 54S ribosomal protein L2, mitochondrial Source.365: DFBPPR15502 ---- Microorganism protein ---- Mitochondrial distribution and morphology protein 32 Source.366: DFBPPR7796 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic Source.367: DFBPPR7855 ---- Plant protein ---- Probable fatty acid desaturase DES1 Source.368: DFBPPR8040 ---- Plant protein ---- Nitrate reductase [NADH] 1 Source.369: DFBPPR8250 ---- Plant protein ---- NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antihypertensive activity

In vitro experiments	Dose (mg/kg)	SBP Decreases	Times
SHR	7	≈ 12 mmHg	2 h
		16.2 ± 3.8 mmHg (p < 0.01)	4 h
		≈ 15 mmHg	6 h
		≈ 13 mmHg	8 h
		≈ 4 mmHg	24 h

Specific target protein(s)

N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	The peptide was obtained from the β-casein f(133-138) HLPLP hydrolyzed with plasma peptidases.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	Non-Toxin
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPACEI0417
[D2]	DFBPMUFU0414

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Sánchez-Rivera, L., Santos, P.F., Miralles, B., Carrón, R., José Montero, M., Recio, I. Peptide fragments from β-casein f(134–138), HLPLP, generated by the action of rat blood plasma peptidases show potent antihypertensive activity. Food Research International. 2016, 88, 348-53. DOI: 10.1016/j.foodres.2015.12.007
Other literature(s)	[1] Laura SánchezRivera, Ares I , Miralles B , et al. Bioavailability and Kinetics of the Antihypertensive Casein-Derived Peptide HLPLP in Rats[J]. Journal of Agricultural & Food Chemistry, 2014, 62(49):11869. [2] Kohmura M, Nio N, Kubo K, et al. Inhibition of angiotensin-converting enzyme by synthetic peptides of human. BETA.-casein[J]. Journal of the Agricultural Chemical Society of Japan, 1989, 53(8):2107-2114.
PubDate	2016