DFBP ID - DFBPANHY0007(Antihypertensive peptide)
DFBP ID
DFBPANHY0007
Peptide sequence
LPL
Type
Native peptide
Peptide/Function name
Antihypertensive peptide
Function-activity relationship
Main bioactivity
Antihypertensive activity
Otheir bioactivity
ACE-inhibitory activity [D1] , Antioxidative activity [D2] , DPP IV-inhibitory activity [D3] , Multifunctional activity [D4]
Calculated physicochemical properties
Three-letter amino acid
Leu -Pro -Leu
Single-letter amino acid
LPL
Peptide length
3
Peptide mass
Experimental mass
Theoretical mass
N.D
341.44 Da c
Net charge
0.00 c
Isoelectric point (pI)
5.97 c
IC50
N.D
pIC50
N.D
GRAVY
2.0000 c
Hydrophilic residue ratio
100% c
Peptide calculator
Biological/Functional activity & target protein
Antihypertensive activity
In vitro experiments Dose (mg/kg) SBP Decreases Times SHR 7 ≈ 12 mmHg 2 h ≈ 16 mmHg 4 h 22.0 ± 2.5 mmHg (p < 0.001) 6 h ≈ 10 mmHg 8 h ≈ 6 mmHg 24 h
Specific target protein(s)
N.D
Taste properties & Structure
Bitterness
Literature report
N.D
Bitter prediction tools
Bitter taste prediction
SMILES
N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Structure
Embedded Mol* Viewer
Docking
Embedded Mol* Viewer
Preparation method
Mode of preparation
Enzymatic hydrolysis
Enzyme(s)/starter culture
The peptide was obtained from the β-casein f(133-138) HLPLP hydrolyzed with plasma peptidases.
Stability & Cytotoxicity
Peptide stability
Peptide cytotoxicity
Literature report:
Non-Toxin
Prediction:
ToxinPred
Additional information
Additional information
N.D
Database cross-references
Reference(s)
Primary literature
Sánchez-Rivera, L., Santos, P.F., Miralles, B., Carrón, R., José Montero, M., Recio, I. Peptide fragments from β-casein f(134–138), HLPLP, generated by the action of rat blood plasma peptidases show potent antihypertensive activity. Food Research International. 2016, 88, 348-53.
Other literature(s)
N.D
PubDate
2016