DFBP ID - DFBPANHY0150(Antihypertensive peptide)

DFBP ID DFBPANHY0150 Peptide sequence LGPVRGPFPIIV Type Native peptide Peptide/Function name Antihypertensive peptide

Function-activity relationship

Main bioactivity Antihypertensive activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val Single-letter amino acid LGPVRGPFPIIV Peptide length 12 Peptide mass Experimental mass Theoretical mass N.D 1264.56 Da c Net charge 0.00 c Isoelectric point (pI) 11.04 c IC50 N.D pIC50 N.D GRAVY 1.1583 c Hydrophilic residue ratio 91.67% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Milk protein Precursor protein β-Casein Residue position f(198-209) Precursor protein(s) search Source.1: DFBPPR7718 ---- Milk proteins ---- Beta-casein Source.2: DFBPPR8489 ---- Milk proteins ---- Beta-casein Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antihypertensive activity The peptide was potential antihypertensive peptide (data not shown). Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O

Preparation method

Mode of preparation Fermentation Enzyme(s)/starter culture Bifidobacterium longum KACC91563

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: Non-Toxin Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

BIOPEP-UWM [D1] -

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Ha GE, Chang OK, Jo SM, Han GS, Park BY, Ham JS, Jeong SG. Identification of Antihypertensive Peptides Derived from Low Molecular Weight Casein Hydrolysates Generated during Fermentation by Bifidobacterium longum KACC 91563. Korean J Food Sci Anim Resour. 2015;35(6):738-47. PMID: 26877633 DOI: 10.5851/kosfa.2015.35.6.738 Other literature(s) N.D PubDate 2015