Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANHY0168(Antihypertensive peptide)

DFBP ID	DFBPANHY0168
Peptide sequence	RVPSL
Type	Native peptide
Peptide/Function name	Antihypertensive peptide

Function-activity relationship

Main bioactivity	Antihypertensive activity
Otheir bioactivity	ACE-inhibitory activity ^[D1], Antithrombotic activity ^[D2], α-Amylase inhibitory activity ^[D3], α-Glucosidase inhibitory activity ^[D4], Multifunctional activity ^[D5]

Calculated physicochemical properties

Three-letter amino acid

Arg-Val-Pro-Ser-Leu

Single-letter amino acid

RVPSL

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	570.68 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

11.04 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

0.2200^c

Hydrophilic residue ratio

60%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Egg
Precursor protein	Ovotransferrin
Residue position	f(328-332)
Precursor protein(s) search	Source.1: DFBPPR1485 ---- Plant proteins ---- Pheophorbide a oxygenase, chloroplastic Source.2: DFBPPR1866 ---- Plant proteins ---- Probable DNA gyrase subunit A, chloroplastic/mitochondrial Source.3: DFBPPR19041 ---- Animal proteins ---- Presenilins-associated rhomboid-like protein, mitochondrial Source.4: DFBPPR9971 ---- Animal proteins ---- Ovotransferrin Source.5: DFBPPR12059 ---- Animal proteins ---- Solute carrier family 46 member 3
Link-research Inductive analysis	Link 1: DFBPANHY0287----Egg----Egg white protein

Biological/Functional activity & target protein

Antihypertensive activity	The peptide showed antihypertensive activity (data not shown).
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	Synthesis peptide

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	Non-Toxin
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPACEI0159
[D2]	DFBPANTH0093
[D3]	DFBPALAM0016
[D4]	DFBPALGL0007
[D5]	DFBPMUFU0062

[D6]

[D7]

[D8]

[D9]

Reference(s)

Primary literature	Ding L, Wang L, Zhang Y, Liu J. Transport of Antihypertensive Peptide RVPSL, Ovotransferrin 328-332, in Human Intestinal Caco-2 Cell Monolayers. J Agric Food Chem. 2015 Sep 23;63(37):8143-50. PMID: 26335384 DOI: 10.1021/acs.jafc.5b01824
Other literature(s)	N.D
PubDate	2015