DFBP ID - DFBPANHY0297(Antihypertensive peptide) |
DFBP ID |
DFBPANHY0297 |
Peptide sequence |
WYT |
Type |
Native peptide |
Peptide/Function name |
Antihypertensive peptide |
|
Function-activity relationship |
Main bioactivity |
Antihypertensive activity |
Otheir bioactivity |
ACE-inhibitory activity [D1], Antioxidative activity [D2], Multifunctional activity [D3] |
|
Calculated physicochemical properties |
Three-letter amino acid |
Trp-Tyr-Thr |
Single-letter amino acid |
WYT |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
469.2 Da |
468.51 Da c |
|
Net charge |
0.00 c |
Isoelectric point (pI) |
5.92 c |
IC50 |
N.D |
pIC50 |
N.D |
GRAVY |
-0.9667 c |
Hydrophilic residue ratio |
33.33% c |
Peptide calculator |
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Biological/Functional activity & target protein |
Antihypertensive activity |
In vitro experiments
| Dose (mg/kg)
| SBP Decreases
| Times | SHR
| 30
| 13 mmHg
| 2 h
|
|
Specific target protein(s) |
N.D |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
Bitter taste prediction |
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SMILES |
N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O |
|
Preparation method |
Mode of preparation |
Enzymatic hydrolysis |
Enzyme(s)/starter culture |
Hemp seed proteins was hydrolyzed by simulating gastrointestinal tract digestion (Pepsin and Pancreatin). |
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Stability & Cytotoxicity |
Peptide stability |
|
Peptide cytotoxicity |
Literature report: |
Non-Toxin |
Prediction: |
ToxinPred |
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Additional information |
Additional information |
The peptide had inhibition for renin (77%).
|
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Database cross-references |
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Reference(s) |
Primary literature |
Girgih, A.T., He, R., Malomo, S., Offengenden, M., Wu, J., Aluko, R.E. Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. Journal of Functional Foods. 2014, 6, 384-94.
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Other literature(s) |
N.D |
PubDate |
2014 |
|