E-mail:gzliang@cqu.edu.cn    Tel: (86)2365102507

List of peptide properties
DFBP ID - DFBPANHY0299(Antihypertensive peptide)
DFBP ID DFBPANHY0299
Peptide sequence IPAGV
Type Native peptide
Peptide/Function name Antihypertensive peptide
Function-activity relationship
Main bioactivity Antihypertensive activity
Otheir bioactivity ACE-inhibitory activity [D1], Antioxidative activity [D2], Multifunctional activity [D3]
Calculated physicochemical properties
Three-letter amino acid Ile-Pro-Ala-Gly-Val
Single-letter amino acid IPAGV
Peptide length 5
Peptide mass
Experimental mass Theoretical mass
456.3 Da 455.55 Da c
Net charge 0.00 c
Isoelectric point (pI) 5.97 c
IC50 N.D
pIC50 N.D
GRAVY 1.7000 c
Hydrophilic residue ratio 100% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Plant
Organism/Source Hemp (Cannabis sativa L.)
Precursor protein Hemp seed protein
Residue position N.D
Precursor protein(s) search
Source.1: DFBPPR1654 ---- Plant proteins ---- Malate dehydrogenase, glyoxysomal
Source.2: DFBPPR2105 ---- Plant proteins ---- Cellulose synthase-like protein D2
Source.3: DFBPPR5083 ---- Plant proteins ---- Malate dehydrogenase, glyoxysomal
Source.4: DFBPPR6525 ---- Plant proteins ---- Plastocyanin, chloroplastic
Source.5: DFBPPR7468 ---- Plant proteins ---- Malate dehydrogenase 2, glyoxysomal
Source.6: DFBPPR7471 ---- Plant proteins ---- Malate dehydrogenase 1, glyoxysomal
Source.7: DFBPPR7487 ---- Plant proteins ---- Malate dehydrogenase, mitochondrial
Source.8: DFBPPR18234 ---- Animal proteins ---- Small nuclear ribonucleoprotein-associated protein B'
Source.9: DFBPPR18393 ---- Animal proteins ---- Malate dehydrogenase, mitochondrial
Source.10: DFBPPR8778 ---- Animal proteins ---- Malate dehydrogenase, mitochondrial
Source.11: DFBPPR8082 ---- Plant protein ---- Plastocyanin
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Antihypertensive activity
In vitro experiments
Dose (mg/kg)
SBP Decreases
Times
SHR
30
36 mmHg
4 h
Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Bitter taste prediction
SMILES N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)O
Preparation method
Mode of preparation Enzymatic hydrolysis
Enzyme(s)/starter culture

Hemp seed proteins was hydrolyzed by simulating gastrointestinal tract digestion (Pepsin and Pancreatin).

Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: Non-Toxin
Prediction: ToxinPred
Additional information
Additional information

The peptide showed 75% renin inhibition.

Database cross-references
DFBP
[D1] DFBPACEI1282
[D2] DFBPANOX0646
[D3] DFBPMUFU0289
BIOPEP-UWM [D4] -
APD [D5] -
BioPepDB [D6] -
MBPDB [D7] -
Reference(s)
Primary literature Girgih, A.T., He, R., Malomo, S., Offengenden, M., Wu, J., Aluko, R.E. Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. Journal of Functional Foods. 2014, 6, 384-94.
Other literature(s) N.D
PubDate 2014
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214