DFBP ID - DFBPANHY0309(Antihypertensive peptide) |
DFBP ID |
DFBPANHY0309 |
Peptide sequence |
GCP |
Type |
Native peptide |
Peptide/Function name |
Antihypertensive peptide |
|
Function-activity relationship |
Main bioactivity |
Antihypertensive activity |
Otheir bioactivity |
N.D |
|
Calculated physicochemical properties |
Three-letter amino acid |
Gly-Cys-Pro |
Single-letter amino acid |
GCP |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
N.D |
275.33 Da c |
|
Net charge |
0.00 c |
Isoelectric point (pI) |
5.33 c |
IC50 |
N.D |
pIC50 |
N.D |
GRAVY |
0.1667 c |
Hydrophilic residue ratio |
66.67% c |
Peptide calculator |
|
|
Biological/Functional activity & target protein |
Antihypertensive activity |
In vitro experiments
| Dose (mg/kg)
| SBP Decreases (Maximal)
| DBP Decreases (Maximal) | SHR
| 2
| 21.87 ± 4.51 mmHg
| 28.5 ± 3.20 mmHg
| Time
| — | 4 h
| 2 h
|
|
Specific target protein(s) |
N.D |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
No prediction can be made about the peptide bitterness. prediction |
|
SMILES |
NCC(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)O |
|
Preparation method |
Mode of preparation |
Enzymatic hydrolysis |
Enzyme(s)/starter culture |
N.D
|
|
Stability & Cytotoxicity |
Peptide stability |
|
Peptide cytotoxicity |
Literature report: |
Non-Toxin |
Prediction: |
ToxinPred |
|
|
Additional information |
Additional information |
N.D |
|
Database cross-references |
|
|
|
|
Reference(s) |
Primary literature |
Wang, S., Lin, L.-m., Wu, Y.-n., Fang, M., Yu, Y.-q., Zhou, J., et al. Angiotensin I Converting Enzyme (ACE) inhibitory activity and antihypertensive effects of grass carp peptides. Food Science and Biotechnology. 2014, 23, 1661-6.
|
Other literature(s) |
N.D |
PubDate |
2014 |
|