In the SHR experiment, statistically insignificant reduction of -4.8 mmHg for Ala-Trp was observed at a lower oral dose (1 mg/kg of body weight), as shown in Table 1. Table 1. Effect of Oral Administration of Peptide on Systolic Blood Pressure in SHR
Sample
| Dose (mg/kg)
| Systolic blood pressure (mmHg) b
| Before administration | Time after administration (h)
| 3
| 6
| 9
| Control
|
| 211.4 ± 8.4
| 218.3 ± 6.0
| 209.6 ± 4.8
| 210.1 ± 4.9
| Ala-Trp | 1 | 231.7 ± 6.7
| 226.9 ± 4.7
| 230.6 ± 6.8
| 230.4 ± 2.2 | Captopril a
| 1
| 238.7 ± 6.9
| 222.2 ± 3.9*
| 221.1 ± 4.0*
| 224.9 ± 4.1* | a Captopril as a positive control. b Systolic blood pressure is shown as mean ± SE, n = 6. * Significantly different from the before administration at p < 0.05 by paired t test. ** Significantly different from the before administration at p < 0.01 by paired t test.
| |