Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANHY0630(Antihypertensive peptide)

DFBP ID	DFBPANHY0630
Peptide sequence	IMY
Type	Native peptide
Peptide/Function name	Antihypertensive peptide

Function-activity relationship

Main bioactivity	Antihypertensive activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Ile-Met-Tyr

Single-letter amino acid

IMY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	425.54 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.92 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

1.7000^c

Hydrophilic residue ratio

66.67%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	royal jelly
Precursor protein	royal jelly glycoprotein
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0747 ---- Plant proteins ---- 11S globulin seed storage protein Source.2: DFBPPR0776 ---- Plant proteins ---- 11S globulin Source.3: DFBPPR0961 ---- Plant proteins ---- Ent-kaurenoic acid oxidase Source.4: DFBPPR0983 ---- Plant proteins ---- Beta-fructofuranosidase, insoluble isoenzyme 2 Source.5: DFBPPR1169 ---- Plant proteins ---- Phototropin-1A Source.6: DFBPPR1282 ---- Plant proteins ---- Calcium-dependent protein kinase 2 Source.7: DFBPPR1341 ---- Plant proteins ---- Calcium-dependent protein kinase 14 Source.8: DFBPPR1345 ---- Plant proteins ---- Cadmium/zinc-transporting ATPase HMA2 Source.9: DFBPPR1370 ---- Plant proteins ---- Phototropin-1B Source.10: DFBPPR1372 ---- Plant proteins ---- Probable beta-1,4-xylosyltransferase IRX9L Source.11: DFBPPR1421 ---- Plant proteins ---- GDP-mannose 3,5-epimerase 1 Source.12: DFBPPR1712 ---- Plant proteins ---- Mixed-linked glucan synthase 4 Source.13: DFBPPR1827 ---- Plant proteins ---- Beta-fructofuranosidase, insoluble isoenzyme 3 Source.14: DFBPPR2121 ---- Plant proteins ---- Cellulose synthase-like protein D5 Source.15: DFBPPR2172 ---- Plant proteins ---- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Source.16: DFBPPR2221 ---- Plant proteins ---- L-galactono-1,4-lactone dehydrogenase 2, mitochondrial Source.17: DFBPPR2296 ---- Plant proteins ---- L-galactono-1,4-lactone dehydrogenase 1, mitochondrial Source.18: DFBPPR2415 ---- Plant proteins ---- Putative aconitate hydratase, cytoplasmic Source.19: DFBPPR2509 ---- Plant proteins ---- Magnesium transporter MRS2-A, chloroplastic Source.20: DFBPPR2794 ---- Plant proteins ---- FACT complex subunit SPT16 Source.21: DFBPPR2891 ---- Plant proteins ---- GDP-mannose 3,5-epimerase 2 Source.22: DFBPPR2972 ---- Plant proteins ---- Probable potassium transporter 14 Source.23: DFBPPR2975 ---- Plant proteins ---- Hydroxycinnamoyltransferase 4 Source.24: DFBPPR3101 ---- Plant proteins ---- Putative potassium transporter 12 Source.25: DFBPPR3582 ---- Plant proteins ---- Bidirectional sugar transporter SWEET7c Source.26: DFBPPR3597 ---- Plant proteins ---- Probable potassium transporter 11 Source.27: DFBPPR3615 ---- Plant proteins ---- Bidirectional sugar transporter SWEET7b Source.28: DFBPPR3642 ---- Plant proteins ---- Putative bidirectional sugar transporter SWEET7e Source.29: DFBPPR3643 ---- Plant proteins ---- Bidirectional sugar transporter SWEET6a Source.30: DFBPPR3654 ---- Plant proteins ---- Bidirectional sugar transporter SWEET7a Source.31: DFBPPR3691 ---- Plant proteins ---- Putative bidirectional sugar transporter SWEET7d Source.32: DFBPPR3869 ---- Plant proteins ---- Potassium transporter 23 Source.33: DFBPPR3917 ---- Plant proteins ---- Bidirectional sugar transporter SWEET6b Source.34: DFBPPR3939 ---- Plant proteins ---- Non-specific lipid-transfer protein 4 Source.35: DFBPPR4000 ---- Plant proteins ---- Potassium transporter 18 Source.36: DFBPPR4022 ---- Plant proteins ---- Protein TIFY 11f Source.37: DFBPPR4258 ---- Plant proteins ---- Probable metal-nicotianamine transporter YSL11 Source.38: DFBPPR4500 ---- Plant proteins ---- Membrane protein PM19L Source.39: DFBPPR4860 ---- Plant proteins ---- Putative B3 domain-containing protein Os03g0621600 Source.40: DFBPPR4910 ---- Plant proteins ---- Calcium-dependent protein kinase 10 Source.41: DFBPPR5075 ---- Plant proteins ---- DNA polymerase delta catalytic subunit Source.42: DFBPPR5099 ---- Plant proteins ---- Metalloendoproteinase 1 Source.43: DFBPPR5294 ---- Plant proteins ---- Protein Ycf2 Source.44: DFBPPR5565 ---- Plant proteins ---- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic Source.45: DFBPPR5599 ---- Plant proteins ---- Pentatricopeptide repeat-containing protein PPR5, chloroplastic Source.46: DFBPPR5699 ---- Plant proteins ---- Sucrose-phosphate synthase Source.47: DFBPPR5707 ---- Plant proteins ---- indole-2-monooxygenase Source.48: DFBPPR5989 ---- Plant proteins ---- CASP-like protein 1C2 Source.49: DFBPPR6369 ---- Plant proteins ---- Phosphoglucomutase, chloroplastic Source.50: DFBPPR6396 ---- Plant proteins ---- Hydroxyproline O-arabinosyltransferase NOD3 Source.51: DFBPPR6415 ---- Plant proteins ---- Trans-cinnamate 4-monooxygenase Source.52: DFBPPR6487 ---- Plant proteins ---- Basic helix-loop-helix protein A Source.53: DFBPPR6559 ---- Plant proteins ---- Truncated basic helix-loop-helix protein A Source.54: DFBPPR6882 ---- Plant proteins ---- Maturase K Source.55: DFBPPR7170 ---- Plant proteins ---- Maturase K Source.56: DFBPPR7405 ---- Plant proteins ---- Sinapine esterase Source.57: DFBPPR7744 ---- Plant proteins ---- Maturase K Source.58: DFBPPR15985 ---- Animal proteins ---- von Willebrand factor Source.59: DFBPPR16050 ---- Animal proteins ---- Dual oxidase 1 Source.60: DFBPPR16111 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Source.61: DFBPPR16174 ---- Animal proteins ---- Guanine nucleotide-binding protein G(q) subunit alpha Source.62: DFBPPR16219 ---- Animal proteins ---- Sodium channel protein type 10 subunit alpha Source.63: DFBPPR16488 ---- Animal proteins ---- Coagulation factor VIII Source.64: DFBPPR16504 ---- Animal proteins ---- Gap junction gamma-1 protein Source.65: DFBPPR16548 ---- Animal proteins ---- Coiled-coil domain-containing protein 39 Source.66: DFBPPR16659 ---- Animal proteins ---- Band 4.1-like protein 5 Source.67: DFBPPR16795 ---- Animal proteins ---- AP-3 complex subunit delta-1 Source.68: DFBPPR16979 ---- Animal proteins ---- Aquaporin-1 Source.69: DFBPPR17038 ---- Animal proteins ---- NAD(P) transhydrogenase, mitochondrial Source.70: DFBPPR17289 ---- Animal proteins ---- Receptor-interacting serine/threonine-protein kinase 2 Source.71: DFBPPR17375 ---- Animal proteins ---- Peptidyl-glycine alpha-amidating monooxygenase Source.72: DFBPPR17438 ---- Animal proteins ---- Disintegrin and metalloproteinase domain-containing protein 10 Source.73: DFBPPR17475 ---- Animal proteins ---- Protein O-glucosyltransferase 1 Source.74: DFBPPR17512 ---- Animal proteins ---- ADP/ATP translocase 1 Source.75: DFBPPR17772 ---- Animal proteins ---- Thyroxine 5-deiodinase Source.76: DFBPPR17785 ---- Animal proteins ---- MAP kinase-activated protein kinase 3 Source.77: DFBPPR17951 ---- Animal proteins ---- Phospholipase DDHD1 Source.78: DFBPPR17997 ---- Animal proteins ---- Tyrosine-protein kinase CSK Source.79: DFBPPR18019 ---- Animal proteins ---- Prostatic acid phosphatase Source.80: DFBPPR18113 ---- Animal proteins ---- Serine/threonine-protein kinase 38 Source.81: DFBPPR18124 ---- Animal proteins ---- ADP/ATP translocase 3 Source.82: DFBPPR18415 ---- Animal proteins ---- Guanine nucleotide-binding protein subunit alpha-14 Source.83: DFBPPR18424 ---- Animal proteins ---- Inositol 1,4,5-trisphosphate receptor type 2 Source.84: DFBPPR18450 ---- Animal proteins ---- ADP/ATP translocase 2 Source.85: DFBPPR18467 ---- Animal proteins ---- Alpha-aminoadipic semialdehyde synthase, mitochondrial Source.86: DFBPPR18483 ---- Animal proteins ---- DNA damage-binding protein 2 Source.87: DFBPPR18498 ---- Animal proteins ---- Neutral cholesterol ester hydrolase 1 Source.88: DFBPPR18706 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Source.89: DFBPPR18803 ---- Animal proteins ---- Sodium-dependent neutral amino acid transporter B(0)AT2 Source.90: DFBPPR18862 ---- Animal proteins ---- C-C chemokine receptor type 7 Source.91: DFBPPR18979 ---- Animal proteins ---- Alpha-2-macroglobulin Source.92: DFBPPR19106 ---- Animal proteins ---- Natural killer cells antigen CD94 Source.93: DFBPPR19282 ---- Animal proteins ---- Serine/threonine-protein kinase 33 Source.94: DFBPPR19344 ---- Animal proteins ---- Regulator of G-protein signaling 9 Source.95: DFBPPR19612 ---- Animal proteins ---- Lysosomal-trafficking regulator Source.96: DFBPPR19735 ---- Animal proteins ---- Complement component C7 Source.97: DFBPPR19825 ---- Animal proteins ---- DNA excision repair protein ERCC-6-like 2 Source.98: DFBPPR19856 ---- Animal proteins ---- L-gulonolactone oxidase Source.99: DFBPPR19919 ---- Animal proteins ---- Tripeptidyl-peptidase 2 Source.100: DFBPPR20029 ---- Animal proteins ---- Sodium- and chloride-dependent glycine transporter 1 Source.101: DFBPPR20059 ---- Animal proteins ---- Band 4.1-like protein 5 Source.102: DFBPPR20220 ---- Animal proteins ---- Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 Source.103: DFBPPR20261 ---- Animal proteins ---- Protein SCO1 homolog, mitochondrial Source.104: DFBPPR20265 ---- Animal proteins ---- Histone-lysine N-methyltransferase EZH1 Source.105: DFBPPR20280 ---- Animal proteins ---- Sodium-dependent phosphate transporter 2 Source.106: DFBPPR20424 ---- Animal proteins ---- E3 ubiquitin-protein ligase RNF170 Source.107: DFBPPR20556 ---- Animal proteins ---- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Source.108: DFBPPR20619 ---- Animal proteins ---- Extracellular matrix protein 2 Source.109: DFBPPR20735 ---- Animal proteins ---- Microtubule-associated tumor suppressor 1 homolog Source.110: DFBPPR20751 ---- Animal proteins ---- Sorting and assembly machinery component 50 homolog Source.111: DFBPPR21025 ---- Animal proteins ---- Radial spoke head protein 3 homolog Source.112: DFBPPR21109 ---- Animal proteins ---- Lysosomal cobalamin transport escort protein LMBD1 Source.113: DFBPPR21275 ---- Animal proteins ---- Gap junction gamma-1 protein Source.114: DFBPPR21309 ---- Animal proteins ---- Coiled-coil domain-containing protein 39 Source.115: DFBPPR21332 ---- Animal proteins ---- ER membrane protein complex subunit 4 Source.116: DFBPPR21467 ---- Animal proteins ---- Striatin-interacting protein 1 Source.117: DFBPPR21597 ---- Animal proteins ---- Hydroxylysine kinase Source.118: DFBPPR21755 ---- Animal proteins ---- ELMO domain-containing protein 2 Source.119: DFBPPR21967 ---- Animal proteins ---- GTP-binding protein 10 Source.120: DFBPPR22248 ---- Animal proteins ---- rRNA-processing protein FCF1 homolog Source.121: DFBPPR22600 ---- Animal proteins ---- Trafficking protein particle complex subunit 13 Source.122: DFBPPR22721 ---- Animal proteins ---- Uncharacterized protein KIAA1143 homolog Source.123: DFBPPR8584 ---- Animal proteins ---- Disintegrin and metalloproteinase domain-containing protein 10 Source.124: DFBPPR8645 ---- Animal proteins ---- NT-3 growth factor receptor Source.125: DFBPPR8748 ---- Animal proteins ---- Dual oxidase 2 Source.126: DFBPPR8754 ---- Animal proteins ---- Dual oxidase 1 Source.127: DFBPPR8847 ---- Animal proteins ---- Guanine nucleotide-binding protein G(q) subunit alpha Source.128: DFBPPR8855 ---- Animal proteins ---- Thyroxine 5-deiodinase Source.129: DFBPPR9217 ---- Animal proteins ---- Coagulation factor VIII Source.130: DFBPPR9260 ---- Animal proteins ---- ADP/ATP translocase 3 Source.131: DFBPPR9265 ---- Animal proteins ---- Pantetheinase Source.132: DFBPPR9364 ---- Animal proteins ---- Gap junction gamma-1 protein Source.133: DFBPPR9379 ---- Animal proteins ---- Secretory carrier-associated membrane protein 1 Source.134: DFBPPR9520 ---- Animal proteins ---- L-gulonolactone oxidase Source.135: DFBPPR9546 ---- Animal proteins ---- 5-hydroxytryptamine receptor 1E Source.136: DFBPPR10021 ---- Animal proteins ---- NT-3 growth factor receptor Source.137: DFBPPR10096 ---- Animal proteins ---- BDNF/NT-3 growth factors receptor Source.138: DFBPPR10173 ---- Animal proteins ---- Teneurin-1 Source.139: DFBPPR10323 ---- Animal proteins ---- Tyrosine-protein kinase BTK Source.140: DFBPPR10350 ---- Animal proteins ---- Protein dispatched homolog 3 Source.141: DFBPPR10358 ---- Animal proteins ---- Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Source.142: DFBPPR10499 ---- Animal proteins ---- Prolactin receptor Source.143: DFBPPR10512 ---- Animal proteins ---- Collagen alpha-1(XIV) chain Source.144: DFBPPR10571 ---- Animal proteins ---- Gap junction gamma-1 protein Source.145: DFBPPR10602 ---- Animal proteins ---- DNA (cytosine-5)-methyltransferase 3A Source.146: DFBPPR10802 ---- Animal proteins ---- Kinesin-like protein KIF18B Source.147: DFBPPR11019 ---- Animal proteins ---- Cadherin-4 Source.148: DFBPPR11461 ---- Animal proteins ---- Solute carrier family 25 member 46 Source.149: DFBPPR11604 ---- Animal proteins ---- Centromere protein I Source.150: DFBPPR11773 ---- Animal proteins ---- Rab GTPase-activating protein 1-like Source.151: DFBPPR11804 ---- Animal proteins ---- WD repeat-containing protein 91 Source.152: DFBPPR11969 ---- Animal proteins ---- Acetoacetyl-CoA synthetase Source.153: DFBPPR12031 ---- Animal proteins ---- Exportin-7 Source.154: DFBPPR12344 ---- Animal proteins ---- MAP kinase-activated protein kinase 2 Source.155: DFBPPR12370 ---- Animal proteins ---- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Source.156: DFBPPR12428 ---- Animal proteins ---- Sodium channel protein type 9 subunit alpha Source.157: DFBPPR12509 ---- Animal proteins ---- H(+)/Cl(-) exchange transporter 3 Source.158: DFBPPR12650 ---- Animal proteins ---- ADP/ATP translocase 1 Source.159: DFBPPR12842 ---- Animal proteins ---- Multidrug and toxin extrusion protein 2 Source.160: DFBPPR12975 ---- Animal proteins ---- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Source.161: DFBPPR13080 ---- Animal proteins ---- Ankyrin repeat domain-containing protein 1 Source.162: DFBPPR13190 ---- Animal proteins ---- Sodium channel protein type 4 subunit alpha Source.163: DFBPPR13342 ---- Animal proteins ---- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Source.164: DFBPPR13469 ---- Animal proteins ---- Cytochrome b Source.165: DFBPPR13587 ---- Animal proteins ---- Aquaporin-1 Source.166: DFBPPR13617 ---- Animal proteins ---- NAD(P) transhydrogenase, mitochondrial Source.167: DFBPPR13712 ---- Animal proteins ---- Cytochrome b Source.168: DFBPPR13726 ---- Animal proteins ---- Thyroxine 5-deiodinase Source.169: DFBPPR13854 ---- Animal proteins ---- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Source.170: DFBPPR14003 ---- Animal proteins ---- Dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 Source.171: DFBPPR14193 ---- Marine protein ---- ER membrane protein complex subunit 4 Source.172: DFBPPR14360 ---- Marine protein ---- Phenylalanine--tRNA ligase beta subunit, chloroplastic Source.173: DFBPPR14669 ---- Marine protein ---- Neuronal acetylcholine receptor subunit alpha-9-I Source.174: DFBPPR14681 ---- Marine protein ---- Neuronal acetylcholine receptor subunit alpha-9-II Source.175: DFBPPR14796 ---- Marine protein ---- Guanine nucleotide-binding protein G(q) subunit alpha Source.176: DFBPPR14813 ---- Marine protein ---- Digestive cysteine proteinase 1 Source.177: DFBPPR14913 ---- Microorganism protein ---- Serine/threonine-protein kinase CBK1 Source.178: DFBPPR14994 ---- Microorganism protein ---- Serine/threonine-protein kinase MEC1 Source.179: DFBPPR15068 ---- Microorganism protein ---- Translation factor GUF1, mitochondrial Source.180: DFBPPR15225 ---- Microorganism protein ---- Acetylornithine aminotransferase, mitochondrial Source.181: DFBPPR15238 ---- Microorganism protein ---- Pre-mRNA-splicing factor CLF1 Source.182: DFBPPR15256 ---- Microorganism protein ---- SEC14 cytosolic factor Source.183: DFBPPR15588 ---- Microorganism protein ---- Protein PNS1 Source.184: DFBPPR15599 ---- Microorganism protein ---- Pre-mRNA-splicing factor SYF1 Source.185: DFBPPR15767 ---- Microorganism protein ---- Protein LOT5 Source.186: DFBPPR15780 ---- Microorganism protein ---- Uncharacterized killer plasmid pGKl-2 protein 8 Source.187: DFBPPR15790 ---- Microorganism protein ---- UPF0507 protein KLLA0D01133g Source.188: DFBPPR15835 ---- Microorganism protein ---- Alcohol dehydrogenase (quinone), dehydrogenase subunit Source.189: DFBPPR15840 ---- Microorganism protein ---- Protein RecA Source.190: DFBPPR15876 ---- Microorganism protein ---- Probable DNA-directed RNA polymerase Source.191: DFBPPR15886 ---- Microorganism protein ---- Capsid protein Source.192: DFBPPR7807 ---- Plant protein ---- Probable O-methyltransferase 2 Source.193: DFBPPR7860 ---- Plant protein ---- CASP-like protein 1C1 Source.194: DFBPPR7942 ---- Plant protein ---- Polyphenol oxidase A1, chloroplastic Source.195: DFBPPR8109 ---- Plant protein ---- Cytochrome P450 85A Source.196: DFBPPR8155 ---- Plant protein ---- Protein Ycf2
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antihypertensive activity	The peptide was a potential antihypertensive peptide (data not shown).
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	gastrointestinal enzyme (porcine gastric mucosa pepsin, bovine pancreas chymotrypsin, and bovine pancreas trypsin from Boehringer Mannheim)

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	Non-Toxin
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Matsui T, Yukiyoshi A, Doi S, Sugimoto H, Yamada H, Matsumoto K. Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J Nutr Biochem. 2002 Feb;13(2):80-86. PMID: 11834223 DOI: 10.1016/s0955-2863(01)00198-x
Other literature(s)	N.D
PubDate	2002