Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANHY0661(Antihypertensive peptide)

DFBP ID	DFBPANHY0661
Peptide sequence	AKYSY
Type	Native peptide
Peptide/Function name	Antihypertensive peptide

Function-activity relationship

Main bioactivity	Antihypertensive activity
Otheir bioactivity	ACE-inhibitory activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Ala-Lys-Tyr-Ser-Tyr

Single-letter amino acid

AKYSY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	630.69 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

9.52 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-1.1000^c

Hydrophilic residue ratio

20%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Nori (Porphyra yezoensis)
Precursor protein	Nori oligopeptide
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR1035 ---- Plant proteins ---- Probable L-ascorbate peroxidase 8, chloroplastic Source.2: DFBPPR1480 ---- Plant proteins ---- CASP-like protein BLE3 Source.3: DFBPPR5989 ---- Plant proteins ---- CASP-like protein 1C2 Source.4: DFBPPR14346 ---- Marine protein ---- R-phycoerythrin alpha chain Source.5: DFBPPR7860 ---- Plant protein ---- CASP-like protein 1C1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antihypertensive activity

Table 1 The antihypertensive activity of synthetic peptide.
Peptide	In vitro experiments	Dose (mg/kg)	SBP decrease (mm Hg)
AKYSY	SHR	10	-30.0
AKYSY	SHR	200	-10.0

Specific target protein(s)

N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	N.D

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	No measured
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPACEI0786, DFBPACEI1325, DFBPACEI2220
[D2]	DFBPMUFU0173

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Martínez-Maqueda D, Miralles B, Recio I, Hernández-Ledesma B. Antihypertensive peptides from food proteins: a review. Food Funct. 2012 Apr;3(4):350-61. PMID: 22249830 DOI: 10.1039/c2fo10192k
Other literature(s)	N.D
PubDate	2012