DFBP ID - DFBPANHY0684(Antihypertensive peptide) |
DFBP ID |
DFBPANHY0684 |
Peptide sequence |
YYA |
Type |
Native peptide |
Peptide/Function name |
Antihypertensive peptide |
|
Function-activity relationship |
Main bioactivity |
Antihypertensive activity |
Otheir bioactivity |
ACE-inhibitory activity [D1], Multifunctional activity [D2] |
|
Calculated physicochemical properties |
Three-letter amino acid |
Tyr-Tyr-Ala |
Single-letter amino acid |
YYA |
Peptide length |
3 |
Peptide mass |
Experimental mass |
Theoretical mass |
N.D |
415.44 Da c |
|
Net charge |
0.00 c |
Isoelectric point (pI) |
5.87 c |
IC50 |
N.D |
pIC50 |
N.D |
GRAVY |
-0.2667 c |
Hydrophilic residue ratio |
33.33% c |
Peptide calculator |
|
|
Biological/Functional activity & target protein |
Antihypertensive activity |
In vitro experiments
| Dose (mg/kg)
| SBP Decreases
| SHR
| 3
| ≈ 12 mmHg
| ≈ 9 mmHg
| Time
| — | 2 h
| 4 h
|
|
Specific target protein(s) |
N.D |
|
Taste properties & Structure |
Bitterness |
Literature report |
N.D |
Bitter prediction tools |
Bitter taste prediction |
|
SMILES |
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)O |
|
Preparation method |
Mode of preparation |
Synthesis |
Enzyme(s)/starter culture |
The synthetic peptide YYA was purchased from Peptide Institute Inc. (Osaka). |
|
Stability & Cytotoxicity |
Peptide stability |
|
Peptide cytotoxicity |
Literature report: |
No measured |
Prediction: |
ToxinPred |
|
|
Additional information |
Additional information |
N.D |
|
Database cross-references |
|
|
|
|
|
Reference(s) |
Primary literature |
Morinaga, Y., Iwai, K., Tomita, H., Takaya, Y., Naraoka, T., Matsue, H. Chemical Nature of a New Antihypertensive Peptide Derived from Jellyfish. Food Science and Technology Research. 2010, 16, 333-40.
|
Other literature(s) |
N.D |
PubDate |
2010 |
|