Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANHY0685(Antihypertensive peptide)

DFBP ID	DFBPANHY0685
Peptide sequence	YYAP
Type	Native peptide
Peptide/Function name	Antihypertensive peptide

Function-activity relationship

Main bioactivity	Antihypertensive activity
Otheir bioactivity	ACE-inhibitory activity ^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

Tyr-Tyr-Ala-Pro

Single-letter amino acid

YYAP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	512.55 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.87 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-0.6000^c

Hydrophilic residue ratio

50%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Marine
Organism/Source	Jellyfish (Stomolophus nomurai)
Precursor protein	Jellyfish powder
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR2287 ---- Plant proteins ---- Dof zinc finger protein 3 Source.2: DFBPPR3529 ---- Plant proteins ---- Probable E3 ubiquitin-protein ligase XBOS36 Source.3: DFBPPR3572 ---- Plant proteins ---- Probable inorganic phosphate transporter 1-9 Source.4: DFBPPR4429 ---- Plant proteins ---- Probable sodium/metabolite cotransporter BASS3, chloroplastic Source.5: DFBPPR4442 ---- Plant proteins ---- Probable sodium/metabolite cotransporter BASS5, chloroplastic Source.6: DFBPPR4617 ---- Plant proteins ---- Probable cleavage and polyadenylation specificity factor subunit 1 Source.7: DFBPPR5221 ---- Plant proteins ---- Protein TIC 214 Source.8: DFBPPR6260 ---- Plant proteins ---- Delta(24)-sterol reductase Source.9: DFBPPR16582 ---- Animal proteins ---- Pepsin A Source.10: DFBPPR18128 ---- Animal proteins ---- Gap junction alpha-3 protein Source.11: DFBPPR19145 ---- Animal proteins ---- Pepsin A Source.12: DFBPPR8843 ---- Animal proteins ---- Pepsin A Source.13: DFBPPR12768 ---- Animal proteins ---- Pepsin-3 Source.14: DFBPPR13590 ---- Animal proteins ---- Gap junction alpha-3 protein Source.15: DFBPPR8120 ---- Plant protein ---- Protein TIC 214 Source.16: DFBPPR8122 ---- Plant protein ---- Arcelin-4 Source.17: DFBPPR8304 ---- Plant protein ---- Protein TIC 214
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antihypertensive activity

In vitro experiments	Dose (mg/kg)	SBP Decreases
SHR	3	≈ 3 mmHg	≈ 4 mmHg
Time	—	4 h	6 h

Specific target protein(s)

N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	The synthetic peptide YYAP was purchased from Peptide Institute Inc. (Osaka).

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	No measured
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPACEI1225
[D2]	DFBPMUFU0263

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Morinaga, Y., Iwai, K., Tomita, H., Takaya, Y., Naraoka, T., Matsue, H. Chemical Nature of a New Antihypertensive Peptide Derived from Jellyfish. Food Science and Technology Research. 2010, 16, 333-40. DOI: 10.3136/fstr.16.333
Other literature(s)	N.D
PubDate	2010