In the SHR experiment, single oral administration of Lys-Pro (50 mg/kg), dissolved in distilled water at a concentration of 10 mg/ml, was performed using 29–30-week-old SHRs having a systolic blood pressure of 195 mmHg or higher. A control group was given the corresponding volume of distilled water. As shown in Table 1, orally administered Lys-Pro shows a tendency to lower the blood pressure of SHRs after 2 to 24 h, but in the distilled water group no change in blood pressure was observed up to 48 h. Table 1. Effect of Oral Administration of Peptide on Systolic Blood Pressure in SHR
Sample
| Dose (mg/kg)
| Systolic blood pressure (mmHg) a
| Time after administration (h)
| 0
| 1
| 2
| 4
| 6
| 8
| 24
| 48
| Control
| distilled water
| 195
| 196
| 196
| 195
| 195
| 196
| 195
| 197
| Lys-Pro
| 50 | 199
| 198
| 191* | 190* | 186 | 187
| 187
| 200
| a Systolic blood pressure is shown as mean ± SD, n = (4-6). * Significantly different from the before administration at p < 0.05 by paired t test.
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