The antihypertensive activity of each peptidic fraction obtained from the pearl oysters was evaluated by measuring the change in SBP at 1h, 2h, 3h, 4h, and 6h after oral administration. Systolic blood pressure did not change in the control rats during the experimental period (6 h). Captopril (10 mg/kg) lowered SBP significantly from 1 h to 4 h after administration of the drug. A single dose of the peptidic fraction from the short-necked clam reduced SBP significantly by 42.2 mmHg at 2 h, and this antihypertensive effect continued for 4 h after administration. The ACE-inhibitory peptide IVE was isolated from the highest active fraction, so the peptide was a potential antihypertensive peptide.
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