(1) The peptide YLG hardly showed antihypertensive effect, as shown in Table 1.
Table 1. Effects of ACE Inhibitory Peptides on SBP of SHR
Sample
| Dose (mg/kg)
| Time after administration (hr), SBP (mmHg)
| 2
| 4
| 6
| 8
| 24
| YLG | 5.0
| 15.0 # | 5.0 # | -5.0
| 3.0 #
| 4.5 # | zofenopril
| -31.0 * | -31.5 *
| -27.5 *
| -26.5 * | 5.0
| Paired
Student’s t test was used to compare different times
post-administration with the corresponding basal pressure values (n = 6, * p < 0.05). Two-way ANOVA following Bonferroni’s post test was performed to assess differences between each peptide versus RYLGY at different times post-administration (# p < 0.05).
| |