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List of peptide properties
DFBP ID - DFBPANOX0499(Antioxidative peptide)
DFBP ID DFBPANOX0499
Peptide sequence KFPE
Type Native peptide
Peptide/Function name Antioxidative peptide
Function-activity relationship
Main bioactivity Antioxidative activity
Otheir bioactivity N.D
Calculated physicochemical properties
Three-letter amino acid Lys-Phe-Pro-Glu
Single-letter amino acid KFPE
Peptide length 4
Peptide mass
Experimental mass Theoretical mass
519.6 Da 519.59 Da c
Net charge 0.00 c
Isoelectric point (pI) 6.92 c
IC50 N.D
pIC50 N.D
GRAVY -1.5500 c
Hydrophilic residue ratio 50% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Animal
Organism/Source Spotless smoothhound (Mustelus griseus)
Precursor protein Ethanol-soluble protein, muscle protein
Residue position N.D
Precursor protein(s) search
Source.1: DFBPPR0927 ---- Plant proteins ---- Serine/threonine-protein kinase TOR
Source.2: DFBPPR1546 ---- Plant proteins ---- Potassium transporter 1
Source.3: DFBPPR1632 ---- Plant proteins ---- ATP-dependent zinc metalloprotease FTSH 6, chloroplastic
Source.4: DFBPPR2135 ---- Plant proteins ---- Putative DNA ligase 4
Source.5: DFBPPR2406 ---- Plant proteins ---- Probable serine/threonine-protein kinase WNK6
Source.6: DFBPPR2464 ---- Plant proteins ---- Two-component response regulator ORR25
Source.7: DFBPPR2881 ---- Plant proteins ---- Probable protein NAP1
Source.8: DFBPPR3602 ---- Plant proteins ---- Coatomer subunit alpha-2
Source.9: DFBPPR3822 ---- Plant proteins ---- Coatomer subunit alpha-3
Source.10: DFBPPR3926 ---- Plant proteins ---- Probable potassium transporter 13
Source.11: DFBPPR3928 ---- Plant proteins ---- Coatomer subunit alpha-1
Source.12: DFBPPR4026 ---- Plant proteins ---- Potassium transporter 19
Source.13: DFBPPR4027 ---- Plant proteins ---- Potassium transporter 20
Source.14: DFBPPR4096 ---- Plant proteins ---- Cytochrome c biogenesis protein CCS1, chloroplastic
Source.15: DFBPPR6475 ---- Plant proteins ---- Probable aquaporin PIP-type 7a
Source.16: DFBPPR16205 ---- Animal proteins ---- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Source.17: DFBPPR16260 ---- Animal proteins ---- Creatine kinase B-type
Source.18: DFBPPR16327 ---- Animal proteins ---- Pituitary-specific positive transcription factor 1
Source.19: DFBPPR16590 ---- Animal proteins ---- Arylsulfatase K
Source.20: DFBPPR16647 ---- Animal proteins ---- Tudor domain-containing protein 7
Source.21: DFBPPR16720 ---- Animal proteins ---- Tudor domain-containing protein 5
Source.22: DFBPPR16986 ---- Animal proteins ---- Aspartyl/asparaginyl beta-hydroxylase
Source.23: DFBPPR17262 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 33
Source.24: DFBPPR17354 ---- Animal proteins ---- Signal transducer and activator of transcription 3
Source.25: DFBPPR17450 ---- Animal proteins ---- Adhesion G protein-coupled receptor L3
Source.26: DFBPPR17527 ---- Animal proteins ---- Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Source.27: DFBPPR17609 ---- Animal proteins ---- Fructose-1,6-bisphosphatase isozyme 2
Source.28: DFBPPR17678 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 16
Source.29: DFBPPR17899 ---- Animal proteins ---- Eukaryotic translation initiation factor 2 subunit 1
Source.30: DFBPPR18540 ---- Animal proteins ---- Fibroblast growth factor-binding protein 1
Source.31: DFBPPR18647 ---- Animal proteins ---- Creatine kinase B-type
Source.32: DFBPPR18757 ---- Animal proteins ---- Mevalonate kinase
Source.33: DFBPPR19409 ---- Animal proteins ---- Hyaluronan-binding protein 2
Source.34: DFBPPR20405 ---- Animal proteins ---- Oxygen-regulated protein 1
Source.35: DFBPPR20550 ---- Animal proteins ---- G-protein coupled receptor family C group 6 member A
Source.36: DFBPPR20641 ---- Animal proteins ---- Centrosomal protein of 41 kDa
Source.37: DFBPPR20850 ---- Animal proteins ---- Arylsulfatase K
Source.38: DFBPPR21118 ---- Animal proteins ---- NADH-cytochrome b5 reductase 1
Source.39: DFBPPR21666 ---- Animal proteins ---- Importin-13
Source.40: DFBPPR22455 ---- Animal proteins ---- Phosducin-like protein 2
Source.41: DFBPPR22512 ---- Animal proteins ---- IQ domain-containing protein C
Source.42: DFBPPR8682 ---- Animal proteins ---- Signal transducer and activator of transcription 3
Source.43: DFBPPR9123 ---- Animal proteins ---- Eukaryotic translation initiation factor 2 subunit 1
Source.44: DFBPPR9406 ---- Animal proteins ---- Creatine kinase B-type
Source.45: DFBPPR9407 ---- Animal proteins ---- Creatine kinase B-type
Source.46: DFBPPR9749 ---- Animal proteins ---- Guanylin
Source.47: DFBPPR9977 ---- Animal proteins ---- Signal transducer and activator of transcription 3
Source.48: DFBPPR10282 ---- Animal proteins ---- Reversion-inducing cysteine-rich protein with Kazal motifs
Source.49: DFBPPR10361 ---- Animal proteins ---- Protein HIRA
Source.50: DFBPPR10451 ---- Animal proteins ---- Eukaryotic translation initiation factor 2 subunit 1
Source.51: DFBPPR10457 ---- Animal proteins ---- Transcriptional enhancer factor TEF-3
Source.52: DFBPPR11037 ---- Animal proteins ---- Disheveled-associated activator of morphogenesis 2
Source.53: DFBPPR11184 ---- Animal proteins ---- Small RNA 2'-O-methyltransferase
Source.54: DFBPPR11251 ---- Animal proteins ---- Transcriptional enhancer factor TEF-5
Source.55: DFBPPR11352 ---- Animal proteins ---- Pituitary-specific positive transcription factor 1
Source.56: DFBPPR11413 ---- Animal proteins ---- Tudor domain-containing protein 7
Source.57: DFBPPR11595 ---- Animal proteins ---- Histone-lysine N-methyltransferase SETD1B
Source.58: DFBPPR11602 ---- Animal proteins ---- Arylsulfatase K
Source.59: DFBPPR11698 ---- Animal proteins ---- NADH-cytochrome b5 reductase 2
Source.60: DFBPPR11988 ---- Animal proteins ---- Transmembrane channel-like protein 3
Source.61: DFBPPR11999 ---- Animal proteins ---- Dymeclin
Source.62: DFBPPR12055 ---- Animal proteins ---- Importin-13
Source.63: DFBPPR12135 ---- Animal proteins ---- Vigilin
Source.64: DFBPPR12438 ---- Animal proteins ---- Fructose-1,6-bisphosphatase isozyme 2
Source.65: DFBPPR14258 ---- Marine protein ---- Pituitary-specific positive transcription factor 1
Source.66: DFBPPR14658 ---- Marine protein ---- Pituitary-specific positive transcription factor 1
Source.67: DFBPPR14973 ---- Microorganism protein ---- Lon protease homolog, mitochondrial
Source.68: DFBPPR14998 ---- Microorganism protein ---- Galactokinase
Source.69: DFBPPR15150 ---- Microorganism protein ---- Ubiquitin carboxyl-terminal hydrolase 2
Source.70: DFBPPR15190 ---- Microorganism protein ---- Pescadillo homolog
Source.71: DFBPPR15366 ---- Microorganism protein ---- DNA-directed RNA polymerases I, II, and III subunit RPABC1
Source.72: DFBPPR15392 ---- Microorganism protein ---- Mediator of RNA polymerase II transcription subunit 16
Source.73: DFBPPR15502 ---- Microorganism protein ---- Mitochondrial distribution and morphology protein 32
Source.74: DFBPPR15516 ---- Microorganism protein ---- mRNA 3'-end-processing protein RNA14
Source.75: DFBPPR15645 ---- Microorganism protein ---- Putative transferase CAF17, mitochondrial
Source.76: DFBPPR15646 ---- Microorganism protein ---- Altered inheritance of mitochondria protein 36, mitochondrial
Source.77: DFBPPR7946 ---- Plant protein ---- Aquaporin PIP1.1
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Antioxidative activity

(1) The purified peptide KFPE exhibited high scavenging activity on hydroxyl radical (IC50 0.1510 mg/ml), ABTS radical (IC50 0.4645 mg/ml), and superoxide radical (IC50 0.2053 mg/ml).
(2) The purified peptide also effectively inhibited the autooxidation in linoleic acid model system.

Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Bitter taste prediction
SMILES N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Preparation method
Mode of preparation

Enzymatic hydrolysis

Enzyme(s)/starter culture

The ethanol-soluble proteins antioxidant hydrolysates were prepared using papain.

Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information

The peptides isolated from the ethanol-soluble proteins hydrolysates of spotless smoothhound muscle were potent antioxidants and might be effectively used as food additives and pharmaceutical agents.

Database cross-references
BIOPEP-UWM [D1] 8985
APD [D2] -
BioPepDB [D3] -
MBPDB [D4] -
Reference(s)
Primary literature Wang, B., Gong, Y.-D., Li, Z.-R., Yu, D., Chi, C.-F., Ma, J.-Y. Isolation and characterisation of five novel antioxidant peptides from ethanol-soluble proteins hydrolysate of spotless smoothhound (Mustelus griseus) muscle. Journal of Functional Foods. 2014, 6, 176-85.
Other literature(s)

[1] Zou, T.B., et al., The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins. Molecules, 2016. 21(1): p. 72.

PubDate 2014
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214