Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANOX0717(Antioxidative peptide)

DFBP ID	DFBPANOX0717
Peptide sequence	FSDKIAK
Type	Native peptide
Peptide/Function name	Antioxidative peptide

Function-activity relationship

Main bioactivity	Antioxidative activity
Otheir bioactivity	ACE-inhibitory activity ^[D1], Antimicrobial activity ^[D2], Multifunctional activity ^[D3]

Calculated physicochemical properties

Three-letter amino acid

Phe-Ser-Asp-Lys-Ile-Ala-Lys

Single-letter amino acid

FSDKIAK

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	807.93 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

9.84 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-0.4286^c

Hydrophilic residue ratio

42.86%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Bovine milk protein
Precursor protein	κ-Casein
Residue position	f(18-24)
Precursor protein(s) search	Source.1: DFBPPR8492 ---- Milk proteins ---- Kappa-casein
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antioxidative activity	The peptide with the sequence FSDKIAK didn't showed oxygen radical-scavenging activity (ORAC-FL value of 0 μmol Trolox* equivalents per μmol of peptide). *Trolox - 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a water-soluble derivative of vitamin E.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Peptide obtained by hydrolysis of bovine κ-casein by use of porcine pepsin A.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPACEI1720
[D2]	DFBPAMIC0491
[D3]	DFBPMUFU0497

[D4]

[D5]

[D6]

[D7]

Reference(s)

Primary literature	López-Expósito, I., Quirós, A., Amigo, L., Recio, I. Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Le Lait. 2007, 87, 241-9. DOI: 10.1051/lait:2007019
Other literature(s)	N.D
PubDate	2007