Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPANTH0005(Antithrombotic peptide)

DFBP ID	DFBPANTH0005
Peptide sequence	MAIPP
Type	Native peptide
Peptide/Function name	Antithrombotic peptide, Casoplatelin

Function-activity relationship

Main bioactivity	Antithrombotic activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Met-Ala-Ile-Pro-Pro

Single-letter amino acid

MAIPP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	527.67 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.97 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

1.0000^c

Hydrophilic residue ratio

100%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Bovine milk protein
Precursor protein	κ-Casein
Residue position	f(106-110)
Precursor protein(s) search	Source.1: DFBPPR2816 ---- Plant proteins ---- WUSCHEL-related homeobox 3 Source.2: DFBPPR7686 ---- Milk proteins ---- Kappa-casein Source.3: DFBPPR7695 ---- Milk proteins ---- Kappa-casein Source.4: DFBPPR7715 ---- Milk proteins ---- Kappa-casein Source.5: DFBPPR8492 ---- Milk proteins ---- Kappa-casein Source.6: DFBPPR15945 ---- Animal proteins ---- Dopamine beta-hydroxylase Source.7: DFBPPR16805 ---- Animal proteins ---- Dopamine beta-hydroxylase Source.8: DFBPPR20100 ---- Animal proteins ---- Sideroflexin-1 Source.9: DFBPPR21503 ---- Animal proteins ---- Sideroflexin-3 Source.10: DFBPPR9524 ---- Animal proteins ---- Sideroflexin-1 Source.11: DFBPPR12907 ---- Animal proteins ---- Cyclin-dependent kinase-like 2 Source.12: DFBPPR13194 ---- Animal proteins ---- Dopamine beta-hydroxylase Source.13: DFBPPR13886 ---- Animal proteins ---- Sideroflexin-1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Antithrombotic activity	The interacting region of the fibrinogen γ-chain in platelet aggregation is the C-terminal dodecapeptide sequence that itself possesses similar inhibiting effects as the peptide MAIPP.
Specific target protein(s)	Specific Target Protein(s): Fibrinogen gamma chain

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Milk proteins were hydrolyzed with trypsin.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Jollès P, Lévy-Toledano S, Fiat AM, Soria C, Gillessen D, Thomaidis A, Dunn FW, Caen JP. Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from kappa-casein on platelet function. Eur J Biochem. 1986 Jul 15;158(2):379-82. PMID: 3732274 DOI: 10.1111/j.1432-1033.1986.tb09764.x
Other literature(s)	[1] Park Y W. Bioactive Components in Milk and Dairy Products[M]. 2009. [2] Fiat A M, Migliore-Samour D, Jollã¨S P, et al. Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities[J]. Journal of Dairy Science, 1993, 76(1):301-310.
PubDate	1986