Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPBBBP0003(Blood-brain barrier peptides)

DFBP ID	DFBPBBBP0003
Peptide sequence	CYIQNCPLG
Type	Native peptide
Peptide/Function name	Blood-brain barrier peptide, Oxytocin

Function-activity relationship

Main bioactivity	Penetrate blood-brain barrier
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly

Single-letter amino acid

CYIQNCPLG

Peptide length

Peptide mass

Experimental mass	Theoretical mass
1007 Da	1010.20 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

5.19 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

0.3333^c

Hydrophilic residue ratio

44.44%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Bovine hypothalamus
Precursor protein	N.D
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR16872 ---- Animal proteins ---- Oxytocin-neurophysin 1 Source.2: DFBPPR9063 ---- Animal proteins ---- Oxytocin-neurophysin 1 Source.3: DFBPPR12867 ---- Animal proteins ---- Oxytocin Source.4: DFBPPR13280 ---- Animal proteins ---- Oxytocin-neurophysin 1 Source.5: DFBPPR13659 ---- Animal proteins ---- Oxytocin-neurophysin 1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Penetrate blood-barin barrier	Brain uptake of OT was similar to that of sucrose, plasma space marker, indicating that OT has a poor BBB permeability.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Separation
Enzyme(s)/starter culture	N.D

Stability & Cytotoxicity

Peptide stability

Literature report:	The OT is a metabolically unstable neuropeptide.
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

Therefore, OT may be transported across the BBB via the mechanism similar to DALDA (diffusion through membrane pores of finite size into the brain).
The oxytocinergic system has a modulatory role in nociception ^[1].

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Kang YS, Park JH. Brain uptake and the analgesic effect of oxytocin--its usefulness as an analgesic agent. Arch Pharm Res. 2000 Aug;23(4):391-5. PMID: 10976589 DOI: 10.1007/BF02975453
Other literature(s)	[1] Lundeberg T, Uvnäs-Moberg K, Agren G, Bruzelius G. Anti-nociceptive effects of oxytocin in rats and mice. Neurosci Lett. 1994 Mar 28;170(1):153-7. doi: 10.1016/0304-3940(94)90262-3. PMID: 8041495.
PubDate	2000