Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPCYPE0007(Cytotoxic peptide)

DFBP ID	DFBPCYPE0007
Peptide sequence	LLATIPKVGVFSILV
Type	Native peptide
Peptide/Function name	Cytotoxic peptide

Function-activity relationship

Main bioactivity	Cytotoxic peptide activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Leu-Leu-Ala-Thr-Ile-Pro-Lys-Val-Gly-Val-Phe-Ser-Ile-Leu-Val

Single-letter amino acid

LLATIPKVGVFSILV

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	1569.97 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

10.04 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

2.0133^c

Hydrophilic residue ratio

80%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Marine
Organism/Source	Marine sponge Xestospongia testudinaria
Precursor protein	The protein hydrolysates of the giant barrel sponge Xestospongia testudinaria
Residue position	N.D
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Cytotoxic activity	The synthetic peptide LLATIPKVGVFSILV didn't showed cytotoxicity toward HeLa cells.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Papain was used to hydrolyze the protein of the giant barrel sponge Xestospongia testudinaria.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Quah, Y., Mohd Ismail, N.I., Ooi, J.L.S., Affendi, Y.A., Abd Manan, F., Wong, F.-C., et al. Identification of Novel Cytotoxic Peptide KENPVLSLVNGMF from Marine Sponge Xestospongia testudinaria, with Characterization of Stability in Human Serum. International Journal of Peptide Research and Therapeutics. 2017, 24, 189-99. DOI: 10.1007/s10989-017-9604-6
Other literature(s)	N.D
PubDate	2017