Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPDPIV0245(DPP IV-inhibitory peptide)

DFBP ID	DFBPDPIV0245
Peptide sequence	γ-EY
Type	Native peptide
Peptide/Function name	DPP-IV inhibitory peptide, Anti-diabetic peptide

Function-activity relationship

Main bioactivity	DPP-IV inhibitory activity
Otheir bioactivity	^[D1], Multifunctional activity ^[D2]

Calculated physicochemical properties

Three-letter amino acid

γ-Glu-Tyr

Single-letter amino acid

γ-EY

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	310.30 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

3.34 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.4000^c

Hydrophilic residue ratio

0%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Synthesis
Organism/Source	Synthesis peptide
Precursor protein	Synthesis peptide
Residue position	N.D
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

DPP IV-inhibitory activity	The peptide γ-EY exhibited a competitive inhibitory effect on Dipeptidyl-peptidase IV (EC 3.4.14.5) with an IC₅₀ value of 6.77 ± 0.68 mM.
Specific target protein(s)	Specific Target Protein(s): Dipeptidyl peptidase 4

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	Commercial synthetic γ-Glu-Tyr with 98% purity (based on MS analysis) were purchased from the Peptide Biological Technology Co., Ltd. (Nanjing, China).

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

DFBP

[D1]	DFBPGAGP0004, DFBPGAGP0005, DFBPGAGP0015, DFBPGAGP0040, DFBPGAGP0052
[D2]	DFBPMUFU0742

[D3]

[D4]

[D5]

[D6]

Reference(s)

Primary literature	Yang, J., et al. γ-Glu-Met synthesised using a bacterial glutaminase as a potential inhibitor of dipeptidyl peptidase IV. Int. J. Food Sci. Technol. 2018;53(5):1166-1175. DOI: 10.1111/ijfs.13692
Other literature(s)	N.D
PubDate	2018