DFBP ID - DFBPHAPE0002(Haemolytic peptide)

DFBP ID DFBPHAPE0002 Peptide sequence FLPLAIGLLGKLF Type Native peptide Peptide/Function name Haemolytic peptide

Function-activity relationship

Main bioactivity Haemolytic activity Otheir bioactivity N.D

Calculated physicochemical properties

Three-letter amino acid Phe-Leu-Pro-Leu-Ala-Ile-Gly-Leu-Leu-Gly-Lys-Leu-Phe Single-letter amino acid FLPLAIGLLGKLF Peptide length 14 Peptide mass Experimental mass Theoretical mass N.D 1401.77 Da c Net charge 0.00 c Isoelectric point (pI) 10.04 c IC50 N.D pIC50 N.D GRAVY 1.8923 c Hydrophilic residue ratio 92.31% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Frog Rana esculenta Precursor protein Crabolin-like from skin of frog Rana esculenta Residue position N.D Precursor protein(s) search No matching precursor protein found Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Haemolytic activity The peptide showed haemolytic activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

BIOPEP-UWM [D1] -

APD [D2] -

BioPepDB [D3] -

MBPDB [D4] -

Reference(s)

Primary literature Saberwal G, Nagaraj R. Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane-perturbing abilities. Biochim Biophys Acta. 1994 Jun 29;1197(2):109-31. PMID: 8031824 DOI: 10.1016/0304-4157(94)90002-7 Other literature(s) N.D PubDate 1994