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List of peptide properties
DFBP ID - DFBPHYCP0009(Hypocholesterolemic peptide)
DFBP ID DFBPHYCP0009
Peptide sequence LPYPR
Type Native peptide
Peptide/Function name Hypocholesterolemic peptide
Function-activity relationship
Main bioactivity Hypocholesterolemic activity
Otheir bioactivity N.D
Calculated physicochemical properties
Three-letter amino acid Leu-Pro-Tyr-Pro-Arg
Single-letter amino acid LPYPR
Peptide length 5
Peptide mass
Experimental mass Theoretical mass
N.D 644.76 Da c
Net charge 0.00 c
Isoelectric point (pI) 9.82 c
IC50 N.D
pIC50 N.D
GRAVY -1.0400 c
Hydrophilic residue ratio 60% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Plant
Organism/Source Soy protein
Precursor protein 11S globulin-derived peptide
Residue position N.D
Precursor protein(s) search
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Hypocholesterolemic activity

An in vitro test for measuring 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR, EC 1.1.1.88) inhibition showed that the synthesized peptide LPYPR spossessed hypocholesterinemic properties. For LPYPR at 200 μM, the percent HMGR inhibition was 33.7%.

Specific target protein(s) Specific Target Protein(s):
3-hydroxy-3-methylglutaryl coenzyme A reductase
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Bitter taste prediction
SMILES N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Preparation method
Mode of preparation

Synthetic peptide

Enzyme(s)/starter culture

The peptide LPYPR was synthetic.

Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
BIOPEP-UWM [D1] -
APD [D2] -
BioPepDB [D3] -
MBPDB [D4] -
Reference(s)
Primary literature Pak, V.V., Koo, M., Lee, N., Kim, M.S., Kwon, D.Y. Structure—Activity Relationships of the Peptide Ile-Ala-Val-Pro and Its Derivatives Revealed Using the Semi-Empirical AM1 Method. Chemistry of Natural Compounds. 2005, 41, 454-60.
Other literature(s) N.D
PubDate 2005
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214