Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPHYCP0022(Hypocholesterolemic peptide)

DFBP ID	DFBPHYCP0022
Peptide sequence	PFVKSEPIPETNNE
Type	Native peptide
Peptide/Function name	Hypocholesterolemic peptide, PEP

Function-activity relationship

Main bioactivity	Hypocholesterolemic activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Pro-Phe-Val-Lys-Ser-Glu-Pro-Ile-Pro-Glu-Thr-Asn-Asn-Glu

Single-letter amino acid

PFVKSEPIPETNNE

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	1600.73 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

4.04 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-1.1571^c

Hydrophilic residue ratio

42.86%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Pigeon pea
Precursor protein	Pigeon pea by-product protein hydrolysate
Residue position	N.D
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Hypocholesterolemic activity	This peptide showed potential inhibitory activity for the 3-hydroxy-3-methylglutaryl CoA reductase (HMGCoAR).
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	No prediction can be made about the peptide bitterness. ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Pigeon pea by-product protein was hydrolyzed with pancreatic at pH 7.5 and temperature 55 °C for 2 h.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Kumar V , Kumar S , Tiku P K . Hypocholesterolemic Effect of Potent Peptide and Bioactive Fraction from Pigeon Pea By-Products in Wistar Rats[J]. International Journal of Peptide Research and Therapeutics, 2021(2):1-13. DOI: 10.1007/s10989-021-10261-5
Other literature(s)	N.D
PubDate	2021