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List of peptide properties
DFBP ID - DFBPICPE0007(Ileum contracting peptide)
DFBP ID DFBPICPE0007
Peptide sequence YPMYPLPR
Type Native peptide
Peptide/Function name Ileum contracting peptide
Function-activity relationship
Main bioactivity Ileum-contracting activity
Otheir bioactivity N.D
Calculated physicochemical properties
Three-letter amino acid Tyr-Pro-Met-Tyr-Pro-Leu-Pro-Arg
Single-letter amino acid YPMYPLPR
Peptide length 8
Peptide mass
Experimental mass Theoretical mass
N.D 1036.24 Da c
Net charge 0.00 c
Isoelectric point (pI) 9.59 c
IC50 N.D
pIC50 N.D
GRAVY -0.7750 c
Hydrophilic residue ratio 62.5% c
Peptide calculator
To calculate the physicochemical properties of bioactive peptide.
Peptide source & Food-borne protein(s) search
Classification Plant
Organism/Source Rice
Precursor protein Rice albumin
Residue position N.D
Precursor protein(s) search
Link-research
There are no literature reports on the discovery of this sequence in other food-source proteins.
Biological/Functional activity & target protein
Ileum contracting activity

The peptide YPMYPLPR exhibits stimulatory activity on ileal contraction.

SequenceRapid
Slow
EC50 ± SE (μM)
n
EC50 ± SE (μM)n
C3a (70-77)
ASHLGLAR16 ± 5.1
4
1.6 ± 0.40
4
OryzatensinGYPMYPLPR4.5 ± 1.6
3
0.082 ± 0.019
4
YPMYPLPR3.7 ± 1.2
3
0.055 ± 0.017
3
PMYPLPR18 ± 4.5
3
0.76 ± 0.11
4
MYPLPR33 ± 13
3
1.2 ± 0.19
3
YPLPR50 ± 3.3
3
2.2 ± 0.82
3
PLPR*
2
59 ± 15
3
YPMYPLP*
2
*
2
The numbers of guinea pigs used are indicated by n.
* No contraction was observed at 1 mM.
Specific target protein(s) N.D
Taste properties & Structure
Bitterness
Literature report N.D
Bitter prediction tools Bitter taste prediction
SMILES N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Preparation method
Mode of preparation

Synthesis

Enzyme(s)/starter culture Peptides used in this study were synthesized by the Fmoc strategy using a Sam 2 peptide synthesizer (Biosearch Inc.). The peptides were purified by reversed-phase HPLC on an octadecyl silica column.
Stability & Cytotoxicity
Peptide stability
Literature report: N.D
EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool)
Peptide cytotoxicity
Literature report: N.D
Prediction: ToxinPred
Additional information
Additional information N.D
Database cross-references
BIOPEP-UWM [D1] 3814
APD [D2] -
BioPepDB [D3] -
MBPDB [D4] -
Reference(s)
Primary literature Takahashi M, Moriguchi S, Ikeno M, Kono S, Ohata K, Usui H, Kurahashi K, Sasaki R, Yoshikawa M. Studies on the ileum-contracting mechanisms and identification as a complement C3a receptor agonist of oryzatensin, a bioactive peptide derived from rice albumin. Peptides. 1996;17(1):5-12.
PMID: 8822503
Other literature(s) N.D
PubDate 1996
Copyright © 2020. Record / license number: Chongqing ICP No. 2000214