Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPIMMU0004(Immunomodulatory peptide)

DFBP ID	DFBPIMMU0004
Peptide sequence	HCQRPR
Type	Native peptide
Peptide/Function name	Immunomodulatory peptide

Function-activity relationship

Main bioactivity	Immunomodulatory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

His-Cys-Gln-Arg-Pro-Arg

Single-letter amino acid

HCQRPR

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	795.92 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

10.89 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.4667^c

Hydrophilic residue ratio

16.67%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Plant
Organism/Source	Soybean
Precursor protein	Seed proteins
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR4965 ---- Plant proteins ---- Glycinin G1
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity	Showed a stimulatory effect on the phagocytic ability of human polymorphonuclear leukocytes and production of tumor necrosis factor in mice.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Hydrolysis with trypsin.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Yoshikawa M, Kishi K, Takahashi M, Watanabe A, Miyamura T, Yamazaki M, Chiba H. Immunostimulating peptide derived from soybean protein. Ann N Y Acad Sci. 1993 Jun 23;685:375-6. PMID: 8363244 DOI: 10.1111/j.1749-6632.1993.tb35892.x
Other literature(s)	[1] Chalamaiah M, Yu W, Wu J. Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review.[J]. Food Chemistry, 2018, 245:205-222.
PubDate	1993