DFBP ID - DFBPIMMU0053(Immunomodulatory peptide)

DFBP ID DFBPIMMU0053 Peptide sequence VEPIPY Type Native peptide Peptide/Function name Immunomodulatory peptide

Function-activity relationship

Main bioactivity Immunomodulatory activity Otheir bioactivity PEP-inhibitory activity [D1], Multifunctional activity [D2]

Calculated physicochemical properties

Three-letter amino acid Val-Glu-Pro-Ile-Pro-Tyr Single-letter amino acid VEPIPY Peptide length 6 Peptide mass Experimental mass Theoretical mass N.D 716.82 Da c Net charge 0.00 c Isoelectric point (pI) 3.34 c IC50 N.D pIC50 N.D GRAVY 0.1167 c Hydrophilic residue ratio 66.67% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Human Organism/Source Casein Precursor protein β-Casein Residue position f(54-59) Precursor protein(s) search Source.1: DFBPPR7605 ---- Milk proteins ---- Beta-casein Link-research Inductive analysis Link 1: DFBPIMMU0001----Human milk----β-Casein

Biological/Functional activity & target protein

Immunomodulatory activity The hexapeptide exhibited significant immunosuppressant activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPPEPI0071 [D2] DFBPMUFU0755

BIOPEP-UWM [D3] 3064

APD [D4] -

BioPepDB [D5] -

MBPDB [D6] -

Reference(s)

Primary literature Bhattacharya M, Puri A, Sahai R, Haq W, Tripathi LM, Srivastava VM. Immunosuppressant activity in human beta-casein fragment analogs. Bioorg Med Chem Lett. 1998 Feb 17;8(4):327-32. PMID: 9871679 DOI: 10.1016/s0960-894x(98)00022-5 Other literature(s) N.D PubDate 1998