Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPIMMU0061(Immunomodulatory peptide)

DFBP ID	DFBPIMMU0061
Peptide sequence	KTPK
Type	Native peptide
Peptide/Function name	Immunomodulatory peptide

Function-activity relationship

Main bioactivity	Immunomodulatory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Lys-Thr-Pro-Lys

Single-letter amino acid

KTPK

Peptide length

Peptide mass

Experimental mass	Theoretical mass
473.5 Da	472.58 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

10.59 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.5250^c

Hydrophilic residue ratio

25%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Growth factor b(TGFb)family
Precursor protein	TGFb protein
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0929 ---- Plant proteins ---- Protein ROS1A Source.2: DFBPPR1827 ---- Plant proteins ---- Beta-fructofuranosidase, insoluble isoenzyme 3 Source.3: DFBPPR2545 ---- Plant proteins ---- Serine/threonine-protein kinase Nek1 Source.4: DFBPPR2553 ---- Plant proteins ---- Probable signal recognition particle 43 kDa protein, chloroplastic Source.5: DFBPPR2832 ---- Plant proteins ---- Probable histone acetyltransferase HAC-like 1 Source.6: DFBPPR2882 ---- Plant proteins ---- Probable histone acetyltransferase HAC-like 2 Source.7: DFBPPR2994 ---- Plant proteins ---- 30S ribosomal protein S4, chloroplastic Source.8: DFBPPR3072 ---- Plant proteins ---- Probable histone H2A.4 Source.9: DFBPPR3481 ---- Plant proteins ---- PHD finger protein ALFIN-LIKE 8 Source.10: DFBPPR3567 ---- Plant proteins ---- U2 small nuclear ribonucleoprotein B'' Source.11: DFBPPR3912 ---- Plant proteins ---- Sialyltransferase-like protein 4 Source.12: DFBPPR4342 ---- Plant proteins ---- Nucleolin 1 Source.13: DFBPPR4430 ---- Plant proteins ---- Nucleolar complex protein 2 homolog Source.14: DFBPPR4929 ---- Plant proteins ---- DNA polymerase I A, chloroplastic Source.15: DFBPPR4983 ---- Plant proteins ---- Protein SRC2 Source.16: DFBPPR5197 ---- Plant proteins ---- Nodulin-21 Source.17: DFBPPR5217 ---- Plant proteins ---- Soyasaponin III rhamnosyltransferase Source.18: DFBPPR5716 ---- Plant proteins ---- Derlin-1.1 Source.19: DFBPPR5717 ---- Plant proteins ---- Derlin-1.2 Source.20: DFBPPR5892 ---- Plant proteins ---- 30S ribosomal protein S4, chloroplastic Source.21: DFBPPR6395 ---- Plant proteins ---- Histone H2A.2 Source.22: DFBPPR6866 ---- Plant proteins ---- 30S ribosomal protein S4, chloroplastic Source.23: DFBPPR7250 ---- Plant proteins ---- 30S ribosomal protein S4, chloroplastic Source.24: DFBPPR8484 ---- Milk proteins ---- Transforming growth factor beta-2 proprotein Source.25: DFBPPR8512 ---- Milk proteins ---- Lysozyme C, milk isozyme Source.26: DFBPPR16297 ---- Animal proteins ---- Nuclear factor NF-kappa-B p105 subunit Source.27: DFBPPR16687 ---- Animal proteins ---- Hepcidin Source.28: DFBPPR16734 ---- Animal proteins ---- 40S ribosomal protein S11 Source.29: DFBPPR17270 ---- Animal proteins ---- Nucleophosmin Source.30: DFBPPR17737 ---- Animal proteins ---- Inactive serine/threonine-protein kinase TEX14 Source.31: DFBPPR17810 ---- Animal proteins ---- Histone H1.2 Source.32: DFBPPR18187 ---- Animal proteins ---- Lithostathine Source.33: DFBPPR18193 ---- Animal proteins ---- Muscarinic acetylcholine receptor M2 Source.34: DFBPPR18287 ---- Animal proteins ---- E3 ubiquitin-protein ligase TRIM56 Source.35: DFBPPR18394 ---- Animal proteins ---- Histone H1.1 Source.36: DFBPPR18453 ---- Animal proteins ---- Potassium voltage-gated channel subfamily KQT member 3 Source.37: DFBPPR18525 ---- Animal proteins ---- Lipoyltransferase 1, mitochondrial Source.38: DFBPPR18879 ---- Animal proteins ---- Corrinoid adenosyltransferase Source.39: DFBPPR18883 ---- Animal proteins ---- Lysozyme C, tracheal isozyme Source.40: DFBPPR19004 ---- Animal proteins ---- Histone H1.3 Source.41: DFBPPR19054 ---- Animal proteins ---- Histidine--tRNA ligase, cytoplasmic Source.42: DFBPPR19523 ---- Animal proteins ---- Origin recognition complex subunit 1 Source.43: DFBPPR19723 ---- Animal proteins ---- Spindle and kinetochore-associated protein 3 Source.44: DFBPPR19918 ---- Animal proteins ---- Histidine--tRNA ligase, mitochondrial Source.45: DFBPPR20165 ---- Animal proteins ---- Lysozyme C, intestinal isozyme Source.46: DFBPPR20564 ---- Animal proteins ---- Ras-related protein Rab-26 Source.47: DFBPPR20793 ---- Animal proteins ---- 39S ribosomal protein L28, mitochondrial Source.48: DFBPPR20810 ---- Animal proteins ---- Zinc finger protein 148 Source.49: DFBPPR20921 ---- Animal proteins ---- TRAF-type zinc finger domain-containing protein 1 Source.50: DFBPPR20985 ---- Animal proteins ---- Transmembrane protein 131-like Source.51: DFBPPR21775 ---- Animal proteins ---- Protein FAM193B Source.52: DFBPPR21780 ---- Animal proteins ---- 40S ribosomal protein S11 Source.53: DFBPPR21799 ---- Animal proteins ---- Major vault protein Source.54: DFBPPR22032 ---- Animal proteins ---- Armadillo-like helical domain-containing protein 4 Source.55: DFBPPR22466 ---- Animal proteins ---- Transcription factor BTF3 homolog 4 Source.56: DFBPPR22580 ---- Animal proteins ---- Paraneoplastic antigen-like protein 8A Source.57: DFBPPR8550 ---- Animal proteins ---- Complement C3 Source.58: DFBPPR8615 ---- Animal proteins ---- Transforming growth factor beta-2 proprotein Source.59: DFBPPR8865 ---- Animal proteins ---- Haptoglobin Source.60: DFBPPR9077 ---- Animal proteins ---- Lysozyme C-2 Source.61: DFBPPR9099 ---- Animal proteins ---- Lysozyme C-3 Source.62: DFBPPR9291 ---- Animal proteins ---- Lysozyme C-1 Source.63: DFBPPR9309 ---- Animal proteins ---- Sperm flagellar protein 2 Source.64: DFBPPR9361 ---- Animal proteins ---- Alpha-2-HS-glycoprotein Source.65: DFBPPR9994 ---- Animal proteins ---- Nuclear factor NF-kappa-B p105 subunit Source.66: DFBPPR10010 ---- Animal proteins ---- Transforming growth factor beta-2 proprotein Source.67: DFBPPR10317 ---- Animal proteins ---- Nucleophosmin Source.68: DFBPPR10337 ---- Animal proteins ---- Alpha-tectorin Source.69: DFBPPR10354 ---- Animal proteins ---- DNA topoisomerase 2-beta Source.70: DFBPPR10863 ---- Animal proteins ---- L-lactate dehydrogenase A chain Source.71: DFBPPR10993 ---- Animal proteins ---- Pericentriolar material 1 protein Source.72: DFBPPR11041 ---- Animal proteins ---- Chromodomain-helicase-DNA-binding protein 7 Source.73: DFBPPR11047 ---- Animal proteins ---- Nucleolin Source.74: DFBPPR11270 ---- Animal proteins ---- Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Source.75: DFBPPR11610 ---- Animal proteins ---- MOB-like protein phocein Source.76: DFBPPR11871 ---- Animal proteins ---- RAD51-associated protein 1 Source.77: DFBPPR11883 ---- Animal proteins ---- Hypoxia up-regulated protein 1 Source.78: DFBPPR11982 ---- Animal proteins ---- Transcription termination factor 3, mitochondrial Source.79: DFBPPR12098 ---- Animal proteins ---- NEDD4-binding protein 1 Source.80: DFBPPR12279 ---- Animal proteins ---- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform Source.81: DFBPPR12441 ---- Animal proteins ---- Triadin Source.82: DFBPPR12447 ---- Animal proteins ---- Canalicular multispecific organic anion transporter 1 Source.83: DFBPPR12571 ---- Animal proteins ---- Inositol hexakisphosphate kinase 2 Source.84: DFBPPR12738 ---- Animal proteins ---- Histone H1.4 Source.85: DFBPPR12935 ---- Animal proteins ---- Histone H1.3 Source.86: DFBPPR13837 ---- Animal proteins ---- ATP synthase protein 8 Source.87: DFBPPR14102 ---- Marine protein ---- Anamorsin-B Source.88: DFBPPR14555 ---- Marine protein ---- Vitellogenin Source.89: DFBPPR14881 ---- Microorganism protein ---- Decapping and exoribonuclease protein 1 Source.90: DFBPPR15299 ---- Microorganism protein ---- Histone chaperone RTT106 Source.91: DFBPPR15761 ---- Microorganism protein ---- Eisosome protein 1 Source.92: DFBPPR7837 ---- Plant protein ---- 30S ribosomal protein S4, chloroplastic
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity	The peptide showed immunomodulatory activity.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Bitter taste ^prediction

SMILES

N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	All the peptides were synthesized by solid-phase methods, using chloromethylated copolymer of styrene and 1% divinyl benzene.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Wieczorek Z, Słoń J, Kluczyk A, Zbozień R, Stafanowicz P, Siemion IZ. The immunomodulatory diversity of the proteins of the transforming growth factor beta (TGF beta) family. Int J Pept Protein Res. 1995 Aug;46(2):113-8. PMID: 8567165 DOI: 10.1111/j.1399-3011.1995.tb01326.x
Other literature(s)	N.D
PubDate	1995