Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPIMMU0084(Immunomodulatory peptide)

DFBP ID	DFBPIMMU0084
Peptide sequence	RKSSK
Type	Native peptide
Peptide/Function name	Immunomodulatory peptide

Function-activity relationship

Main bioactivity	Immunomodulatory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Arg-Lys-Ser-Ser-Lys

Single-letter amino acid

RKSSK

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	604.70 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

11.68 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.7800^c

Hydrophilic residue ratio

0%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	C-terminal part of interleukin-1 (IL-1) receptor antagonis
Precursor protein	IL-1 protein
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0923 ---- Plant proteins ---- Lysine-specific demethylase JMJ703 Source.2: DFBPPR3587 ---- Plant proteins ---- Auxin transport protein BIG Source.3: DFBPPR6647 ---- Plant proteins ---- 2-carboxy-D-arabinitol-1-phosphatase Source.4: DFBPPR7683 ---- Milk proteins ---- Lactotransferrin Source.5: DFBPPR7713 ---- Milk proteins ---- Lactotransferrin Source.6: DFBPPR8500 ---- Milk proteins ---- Lactotransferrin Source.7: DFBPPR17405 ---- Animal proteins ---- Transcription factor HES-1 Source.8: DFBPPR20743 ---- Animal proteins ---- Myozenin-1 Source.9: DFBPPR21025 ---- Animal proteins ---- Radial spoke head protein 3 homolog Source.10: DFBPPR22743 ---- Animal proteins ---- CMT1A duplicated region transcript 4 protein homolog Source.11: DFBPPR9346 ---- Animal proteins ---- Myozenin-1 Source.12: DFBPPR11182 ---- Animal proteins ---- Transcription factor HES-1 Source.13: DFBPPR11392 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 37 Source.14: DFBPPR14930 ---- Microorganism protein ---- Vacuolar protein sorting-associated protein 27
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity	The peptide RKSSK from the N-terminal part of IL-1Ra, although inactive with regard to the inhibition of IL-1-IL-1 receptor interaction, reduces immune response in a manner similar to cyclosporin A (DTH, PFC in vivo).
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	Synthesis peptide

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Wieczorek Z, Kluczyk A, Słoń-Usakiewicz JJ, Siemion IZ. A hexapeptide VTKFYF from C-terminal part of interleukin-1 receptor antagonist, an inhibitor of IL-1-IL-1 receptor interaction. Pol J Pharmacol. 1997 Mar-Jun;49(2-3):107-17. PMID: 9437757
Other literature(s)	N.D
PubDate	1997