Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPIMMU0086(Immunomodulatory peptide)

DFBP ID	DFBPIMMU0086
Peptide sequence	TKRP
Type	Native peptide
Peptide/Function name	Immunomodulatory peptide

Function-activity relationship

Main bioactivity	Immunomodulatory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Thr-Lys-Arg-Pro

Single-letter amino acid

TKRP

Peptide length

Peptide mass

Experimental mass	Theoretical mass
N.D	500.59 Da ^c

Net charge

0.00 ^c

Isoelectric point (pI)

11.54 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

-2.6750^c

Hydrophilic residue ratio

25%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Tuftsin-kentsin group
Precursor protein	Tuftsin
Residue position	N.D
Precursor protein(s) search	Source.1: DFBPPR0942 ---- Plant proteins ---- Lysine-specific demethylase JMJ705 Source.2: DFBPPR1392 ---- Plant proteins ---- Isocitrate lyase Source.3: DFBPPR1944 ---- Plant proteins ---- S-adenosylmethionine synthase 1 Source.4: DFBPPR2022 ---- Plant proteins ---- S-adenosylmethionine synthase 2 Source.5: DFBPPR2027 ---- Plant proteins ---- Delta-aminolevulinic acid dehydratase, chloroplastic Source.6: DFBPPR2143 ---- Plant proteins ---- S-adenosylmethionine synthase 3 Source.7: DFBPPR2219 ---- Plant proteins ---- DNA excision repair protein CSB Source.8: DFBPPR2498 ---- Plant proteins ---- CBL-interacting protein kinase 20 Source.9: DFBPPR2513 ---- Plant proteins ---- Beta-glucosidase 25 Source.10: DFBPPR3559 ---- Plant proteins ---- Putative protein phosphatase 2C 22 Source.11: DFBPPR3901 ---- Plant proteins ---- Growth-regulating factor 9 Source.12: DFBPPR4211 ---- Plant proteins ---- Probable GTP-binding protein OBGM, mitochondrial Source.13: DFBPPR4709 ---- Plant proteins ---- Protein argonaute 17 Source.14: DFBPPR4720 ---- Plant proteins ---- Zinc finger CCCH domain-containing protein 8 Source.15: DFBPPR4741 ---- Plant proteins ---- Putative B3 domain-containing protein Os04g0347400 Source.16: DFBPPR5096 ---- Plant proteins ---- Isocitrate lyase 2 Source.17: DFBPPR5098 ---- Plant proteins ---- Isocitrate lyase 1 Source.18: DFBPPR5659 ---- Plant proteins ---- Phytoene synthase 1, chloroplastic Source.19: DFBPPR6298 ---- Plant proteins ---- S-adenosylmethionine synthase 2 Source.20: DFBPPR6491 ---- Plant proteins ---- Early nodulin-5 Source.21: DFBPPR6738 ---- Plant proteins ---- S-adenosylmethionine synthase Source.22: DFBPPR7094 ---- Plant proteins ---- S-adenosylmethionine synthase 1 Source.23: DFBPPR7095 ---- Plant proteins ---- S-adenosylmethionine synthase 2 Source.24: DFBPPR7096 ---- Plant proteins ---- S-adenosylmethionine synthase 3 Source.25: DFBPPR7097 ---- Plant proteins ---- S-adenosylmethionine synthase 4 Source.26: DFBPPR15950 ---- Animal proteins ---- Unconventional myosin-Id Source.27: DFBPPR16178 ---- Animal proteins ---- Wee1-like protein kinase 2 Source.28: DFBPPR17394 ---- Animal proteins ---- Diacylglycerol kinase alpha Source.29: DFBPPR17838 ---- Animal proteins ---- Lon protease homolog, mitochondrial Source.30: DFBPPR17917 ---- Animal proteins ---- Poly(ADP-ribose) glycohydrolase Source.31: DFBPPR18213 ---- Animal proteins ---- Transformer-2 protein homolog beta Source.32: DFBPPR18913 ---- Animal proteins ---- NLR family CARD domain-containing protein 4 Source.33: DFBPPR18975 ---- Animal proteins ---- Ribosome maturation protein SBDS Source.34: DFBPPR19761 ---- Animal proteins ---- N-chimaerin Source.35: DFBPPR20233 ---- Animal proteins ---- Beta-catenin-like protein 1 Source.36: DFBPPR20636 ---- Animal proteins ---- Transforming growth factor-beta receptor-associated protein 1 Source.37: DFBPPR21045 ---- Animal proteins ---- Rho GTPase-activating protein 10 Source.38: DFBPPR21131 ---- Animal proteins ---- Dynein regulatory complex subunit 7 Source.39: DFBPPR21263 ---- Animal proteins ---- Enhancer of rudimentary homolog Source.40: DFBPPR21507 ---- Animal proteins ---- Nitric oxide-associated protein 1 Source.41: DFBPPR21622 ---- Animal proteins ---- 60S ribosomal protein L7a Source.42: DFBPPR22132 ---- Animal proteins ---- 60S ribosomal protein L18a Source.43: DFBPPR22146 ---- Animal proteins ---- Leucine-rich repeat-containing protein 41 Source.44: DFBPPR22276 ---- Animal proteins ---- Protein MEMO1 Source.45: DFBPPR22535 ---- Animal proteins ---- Protein FAM205C Source.46: DFBPPR8597 ---- Animal proteins ---- Diacylglycerol kinase alpha Source.47: DFBPPR9926 ---- Animal proteins ---- 60S ribosomal protein L7a Source.48: DFBPPR10317 ---- Animal proteins ---- Nucleophosmin Source.49: DFBPPR10374 ---- Animal proteins ---- Cadherin-1 Source.50: DFBPPR10497 ---- Animal proteins ---- Ubiquitin carboxyl-terminal hydrolase 7 Source.51: DFBPPR10555 ---- Animal proteins ---- Fanconi anemia group M protein Source.52: DFBPPR10664 ---- Animal proteins ---- Unconventional myosin-Ig Source.53: DFBPPR11103 ---- Animal proteins ---- Ribosome maturation protein SBDS Source.54: DFBPPR11190 ---- Animal proteins ---- Mitochondrial tRNA-specific 2-thiouridylase 1 Source.55: DFBPPR11491 ---- Animal proteins ---- Vacuolar protein sorting-associated protein 53 homolog Source.56: DFBPPR12154 ---- Animal proteins ---- 60S ribosomal protein L7a Source.57: DFBPPR12303 ---- Animal proteins ---- Histidine-rich glycoprotein Source.58: DFBPPR12625 ---- Animal proteins ---- Dimethylaniline monooxygenase [N-oxide-forming] 4 Source.59: DFBPPR12861 ---- Animal proteins ---- Leukocyte cell-derived chemotaxin 1 Source.60: DFBPPR13681 ---- Animal proteins ---- Pregnancy-associated glycoprotein 1 Source.61: DFBPPR14218 ---- Marine protein ---- 60S ribosomal protein L18a
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity	The peptide can modulate immunobiological activities.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	No prediction can be made about the peptide bitterness. ^prediction

SMILES

N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O

Preparation method

Mode of preparation	Synthesis
Enzyme(s)/starter culture	Synthesis of all peptides was carried out according to the solid phase procedure by using a t-Boc protection on a 9500 peptide synthesizer (MilliGen/Biosearch).

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	Wieczorek, Z., Zimecki, M., Słoń, J.J., Siemion, I.Z. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994, 15, 215-21. DOI: 10.1016/0196-9781(94)90005-1
Other literature(s)	N.D
PubDate	1994