DFBP ID - DFBPIMMU0090(Immunomodulatory peptide)

DFBP ID DFBPIMMU0090 Peptide sequence LLYQEPVLGPVRGPFPIIV Type Native peptide Peptide/Function name Immunomodulatory peptide

Function-activity relationship

Main bioactivity Immunomodulatory activity Otheir bioactivity ACE-inhibitory activity [D1], Antihypertensive activity [D2], Multifunctional activity [D3]

Calculated physicochemical properties

Three-letter amino acid Leu-Leu-Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val Single-letter amino acid LLYQEPVLGPVRGPFPIIV Peptide length 19 Peptide mass Experimental mass Theoretical mass N.D 2107.55 Da c Net charge 0.00 c Isoelectric point (pI) 6.88 c IC50 N.D pIC50 N.D GRAVY 0.8316 c Hydrophilic residue ratio 78.95% c Peptide calculator To calculate the physicochemical properties of bioactive peptide.

Peptide source & Food-borne protein(s) search

Classification Animal Organism/Source Bovine Precursor protein β-Casein Residue position f(1-28) Precursor protein(s) search Source.1: DFBPPR7718 ---- Milk proteins ---- Beta-casein Source.2: DFBPPR8489 ---- Milk proteins ---- Beta-casein Link-research Inductive analysis There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity The peptide showed immunomodulatory activity. Specific target protein(s) N.D

Taste properties & Structure

Bitterness Literature report N.D Bitter prediction tools Bitter taste prediction SMILES N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O

Preparation method

Mode of preparation Synthesis Enzyme(s)/starter culture Synthesis peptide

Stability & Cytotoxicity

Peptide stability Literature report: N.D EHP-Tool: Enzymatic Hydrolysis Prediction Tool (EHP-Tool) Peptide cytotoxicity Literature report: N.D Prediction: ToxinPred

Additional information

Additional information N.D

Database cross-references

DFBP [D1] DFBPACEI1154 [D2] DFBPANHY0122 [D3] DFBPMUFU0227

BIOPEP-UWM [D4] 8174

APD [D5] -

BioPepDB [D6] -

MBPDB [D7] -

Reference(s)

Primary literature Hayes M, Stanton C, Fitzgerald GF, Ross RP. Putting microbes to work: dairy fermentation, cell factories and bioactive peptides. Part II: bioactive peptide functions. Biotechnol J. 2007 Apr;2(4):435-49. PMID: 17407211 DOI: 10.1002/biot.200700045 Other literature(s) N.D PubDate 2007