Peptide properties

1Top 2Function-activity relationship 3Calculated physicochemical properties 4Peptide source & Food-borne protein(s) search 5Biological/Functional activity & target protein 6Taste properties & Structure 7Preparation method 8Stability & Cytotoxicity 9Additional information 10Database cross-references 11Reference(s)

List of peptide properties

DFBP ID - DFBPIMMU0104(Immunomodulatory peptide)

DFBP ID	DFBPIMMU0104
Peptide sequence	ISSTVSLKM
Type	Native peptide
Peptide/Function name	Immunomodulatory peptide

Function-activity relationship

Main bioactivity	Immunomodulatory activity
Otheir bioactivity	N.D

Calculated physicochemical properties

Three-letter amino acid

Ile-Ser-Ser-Thr-Val-Ser-Leu-Lys-Met

Single-letter amino acid

ISSTVSLKM

Peptide length

Peptide mass

Experimental mass	Theoretical mass
964.5351 Da	965.16 Da ^c

Net charge

Isoelectric point (pI)

10.04 ^c

IC₅₀

N.D

pIC₅₀

N.D

GRAVY

0.8222^c

Hydrophilic residue ratio

44.44%^c

Peptide calculator

Peptide source & Food-borne protein(s) search

Classification	Animal
Organism/Source	Duck egg white
Precursor protein	Ovalbumin
Residue position	f(316–324)
Precursor protein(s) search	No matching precursor protein found
Link-research Inductive analysis	There are no literature reports on the discovery of this sequence in other food-source proteins.

Biological/Functional activity & target protein

Immunomodulatory activity	As shown in Table 3, the peptide ISSTVSLKM showed strong immunomodulatory activity.
Specific target protein(s)	N.D

Taste properties & Structure

Bitterness

Literature report	N.D
Bitter prediction tools	Non-bitter taste ^prediction

SMILES

N.D

Preparation method

Mode of preparation	Enzymatic hydrolysis
Enzyme(s)/starter culture	Among the hydrolysates catalyzed by five proteases (Neutrase, Protamex, Alcalase, Flavourzyme, Papain), papain hydrolysate shows the highest degree of hydrolysis and the strongest immunomodulatory activity.

Stability & Cytotoxicity

Peptide stability

Literature report:	N.D
EHP-Tool:	Enzymatic Hydrolysis Prediction Tool (EHP-Tool)

Peptide cytotoxicity

Literature report:	N.D
Prediction:	ToxinPred

Additional information

N.D

Database cross-references

[D1]

[D2]

[D3]

[D4]

Reference(s)

Primary literature	He P , Wang Q , Zhan Q , Pan L , Xin X , Wu H , Zhang M . Purification and characterization of immunomodulatory peptides from enzymatic hydrolysates of duck egg ovalbumin. Food Funct. 2021 Jan 21;12(2):668-681. PMID: 33410435 DOI: 10.1039/d0fo02674c
Other literature(s)	N.D
PubDate	2021